Kafatos:pove new new page: Difference between revisions
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===Current Research Interests=== | ===Current Research Interests=== | ||
<font size=2>I am a postdoctoral fellow in the Kafatos/Christophides lab at Imperial College London. My research focuses on how the innate immune system of the mosquito recognizes and eliminates malaria parasites. Though it is not widely known, mosquitoes are amazing parasite killers. In fact, the vast majority of the parasites ingested when a mosquito bites a malarious person are attacked and eliminated before they can mount an infection. It is the few parasites that survive (one is enough), that are ultimately responsible for disease transmission. | <font size=2>I am a postdoctoral fellow in the [[kafatos:Kafatos/Christophides Lab|Kafatos/Christophides lab]] at [http://www.imperial.ac.uk/ Imperial College London]. My research focuses on how the innate immune system of the mosquito recognizes and eliminates malaria parasites. Though it is not widely known, mosquitoes are amazing parasite killers. In fact, the vast majority of the parasites ingested when a mosquito bites a malarious person are attacked and eliminated before they can mount an infection. It is the few parasites that survive (one is enough), that are ultimately responsible for disease transmission. | ||
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We found that LRIM1 and APL1C are defining members of a protein family, named LRIMs (pronounced L-rims) <cite>Pove-Science-2009</cite>. Bioinformatic searches using specific features shared between LRIM1 and APL1C has uncovered approximately 20 family members falling into four distinct sub-families in Anopheles gamibae, Aedes aegypti and Culex quinquefasciatus but none in any other organisms. Given the central role of LRR proteins in host defense in plants and animals, we are currently investigating the hypothesis that the repertoire of LRIMs may help the mosquito neutralize diverse pathogens, including the agents of human and animal diseases that they transmit.</font> | We found that LRIM1 and APL1C are defining members of a protein family, named LRIMs (pronounced L-rims) <cite>Pove-Science-2009</cite>. Bioinformatic searches using specific features shared between LRIM1 and APL1C has uncovered approximately 20 family members falling into four distinct sub-families in Anopheles gamibae, Aedes aegypti and Culex quinquefasciatus but none in any other organisms. Given the central role of LRR proteins in host defense in plants and animals, we are currently investigating the hypothesis that the repertoire of LRIMs may help the mosquito neutralize diverse pathogens, including the agents of human and animal diseases that they transmit.</font> | ||
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Revision as of 12:14, 31 March 2009
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Laboratory of Immunogenomics |
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Current Research InterestsI am a postdoctoral fellow in the Kafatos/Christophides lab at Imperial College London. My research focuses on how the innate immune system of the mosquito recognizes and eliminates malaria parasites. Though it is not widely known, mosquitoes are amazing parasite killers. In fact, the vast majority of the parasites ingested when a mosquito bites a malarious person are attacked and eliminated before they can mount an infection. It is the few parasites that survive (one is enough), that are ultimately responsible for disease transmission.
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