Karenliu
The Liu Lab | Department of Craniofacial Biology | Kings College London |
Home | Research | Publications | Protocols & Etc. | Lab Members | Contact Us | Links |
Welcome to the Liu lab!
We are interested in signal transduction in developmental biology.
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. Rather than screen for small molecule-protein interactions we have chosen to use a directed approach to making chemically sensitive protein alleles, in which we use drug-dependent tags to regulate protein stability and localization.
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
<wikionly>
Recent updates to the lab wiki
- N
- This edit created a new page (also see list of new pages)
- m
- This is a minor edit
- b
- This edit was performed by a bot
- (±123)
- The page size changed by this number of bytes
22 April 2024
|
19:28 | "Pick and Place" Assembly of Parts Using PDMS - Amy Lim, Rylie Costello 4 changes history +1 [Rcostello (4×)] | |||
|
19:28 (cur | prev) −2 Rcostello talk contribs (→Nanowires) | ||||
|
19:26 (cur | prev) 0 Rcostello talk contribs (→Biology-Inspired Solution) | ||||
|
15:03 (cur | prev) +2 Rcostello talk contribs (→At the Microscale) | ||||
|
15:02 (cur | prev) +1 Rcostello talk contribs (→Overview) |
09:24 | CHEM-ENG590E:Wiki Textbook diffhist +16 Rcostello talk contribs (→Chapter 15 - Other Topics) |
09:24 | Move log Rcostello talk contribs moved page "Pick and Place" Assembly of Parts Using PDMS - Amy Lim to "Pick and Place" Assembly of Parts Using PDMS - Amy Lim, Rylie Costello |
08:59 | "Pick and Place" Assembly of Parts Using PDMS - Amy Lim diffhist −2,792 Rcostello talk contribs (→"Pick and Place" for Microfluidics) |
21 April 2024
22:55 | Lee:JC diffhist +24 Wooin Lee talk contribs (→2024) |
17:42 | Ernesto-Perez-Rueda:Publications diffhist +55 Ernesto Perez-Rueda talk contribs |
19 April 2024
|
21:58 | Hu 2 changes history +58 [Hugangqing (2×)] | |||
|
21:58 (cur | prev) −8 Hugangqing talk contribs | ||||
|
21:58 (cur | prev) +66 Hugangqing talk contribs |
18 April 2024
15:01 | Pan:Who we are diffhist +14 Taopan talk contribs |
|
15:00 | Pan:Methods 2 changes history +456 [Taopan (2×)] | |||
|
15:00 (cur | prev) +2 Taopan talk contribs | ||||
|
14:59 (cur | prev) +454 Taopan talk contribs |
|
14:56 | Pan:Publications 2 changes history +396 [Taopan (2×)] | |||
|
14:56 (cur | prev) +74 Taopan talk contribs | ||||
|
14:54 (cur | prev) +322 Taopan talk contribs |
13:03 | BioMicroCenter:Pricing diffhist +166 Challee talk contribs |
|
12:58 | BioMicroCenter:Singular Sequencing 2 changes history +124 [Challee (2×)] | |||
|
12:58 (cur | prev) +14 Challee talk contribs (→Things to Consider) | ||||
|
12:57 (cur | prev) +110 Challee talk contribs |
|
12:12 | BioMicroCenter:Tecan Freedom Evo 7 changes history +1,746 [Noelani Kamelamela (7×)] | |||
|
12:12 (cur | prev) +4 Noelani Kamelamela talk contribs | ||||
|
12:12 (cur | prev) +3 Noelani Kamelamela talk contribs | ||||
|
10:13 (cur | prev) +7 Noelani Kamelamela talk contribs (→verrity Chemagic 360) | ||||
|
10:08 (cur | prev) −42 Noelani Kamelamela talk contribs (→verrity Chemagic 360) | ||||
|
10:08 (cur | prev) +86 Noelani Kamelamela talk contribs (→verrity Chemagic 360) | ||||
|
09:34 (cur | prev) +23 Noelani Kamelamela talk contribs (→verrity Chemagic 360) | ||||
|
09:32 (cur | prev) +1,665 Noelani Kamelamela talk contribs |
11:42 | 3D Cell Culture - McLean Taggart, Emma Villares, Maximillian Marek, Scott LeBlanc, Adam Lyons and Jacob Belden diffhist −3 Sarah L. Perry talk contribs |
|
09:35 | BioMicroCenter 2 changes history +92 [Noelani Kamelamela (2×)] | |||
|
09:35 (cur | prev) +60 Noelani Kamelamela talk contribs | ||||
|
09:20 (cur | prev) +32 Noelani Kamelamela talk contribs |
09:32 | Upload log Noelani Kamelamela talk contribs uploaded File:Chemagic360.jpg (from manual) |
17 April 2024
<nonwikionly> This page was created using Open Wetware.</nonwikionly>