Karenliu:Lab Members: Difference between revisions

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Principal Investigator
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==Principal Investigator==
[[Image:KarenLiu2.jpg|center|210px]]
[[Image:KarenLiu2.jpg|right|150px]]  
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====Dr. Karen J. Liu====
 
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'''Dr. Karen J. Liu'''


'''Previous Positions'''<br>
'''Previous Positions'''<br>
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'''1992-1995''' Pei Cobb Freed & Partners, ''Architects''  (formerly I.M.Pei & Partners)<br>
'''1992-1995''' Pei Cobb Freed & Partners, ''Architects''  (formerly I.M.Pei & Partners)<br>
'''1988-1992''' Columbia College, Columbia University: BA, English/Architecture
'''1988-1992''' Columbia College, Columbia University: BA, English/Architecture
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Post-doc
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==Post-docs==
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[[Image:Sandraklab.JPG|center|210px]]
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'''Dr. Sandra Gonzalez Malagon'''
'''Dr. Sandra Gonzalez Malagon'''


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'''Project:''' Small molecule control of Wnt signal transduction<br>
'''Project:''' Small molecule control of Wnt signal transduction<br>
'''Summary:''' In this project, we have two broad goals: First, we are creating new alleles of β-catenin, using an approach called inducible stabilization. Second, we are exploiting reversible chemical control to study the genetic requirements of GSK-3 and β-catenin during neural crest migration. We hope that this project will provide a suite of broadly applicable tools for the study of Wnt signaling, as well as valuable insight into the mechanisms underlying neural crest migration.
'''Summary:''' In this project, we have two broad goals: First, we are creating new alleles of β-catenin, using an approach called inducible stabilization. Second, we are exploiting reversible chemical control to study the genetic requirements of GSK-3 and β-catenin during neural crest migration. We hope that this project will provide a suite of broadly applicable tools for the study of Wnt signaling, as well as valuable insight into the mechanisms underlying neural crest migration.
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==Students==
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PhD Students
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[[Image:Basilklab.JPG|top|210px]]
'''Basil Yannakoudakis''' PhD Student
'''Basil Yannakoudakis''' PhD Student
'''Project:''' Genetic Requirements in Craniofacial Skeletogenesis
'''Project:''' Genetic Requirements in Craniofacial Skeletogenesis
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'''Aida Mesbahi''' MSc Student
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'''Project:''' Requirements for FUZ in palate development
[[Image:Sandraklab.JPG|top|210px]]
'''Kshemendra Senarath-Yapa''' Overseas Phd


'''Wills Barrell''' BDS Student
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'''Project:''' Ossification of the Skull Vault


'''Yvonne Yeung''' BDS Student
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'''Project:''' Development of the palatine bone
Undergraduate Students
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'''Zenab Sher''' BMS Student
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'''Project:''' Syndromic tracheal defects
[[Image:Willklab.JPG|top|210px]]


==Former Post-docs==
'''William Barrell''' BDS Student


'''Project:''' Ossification of the Skull Vault
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'''Dr. Heather Szabo-Rogers'''
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'''Now an Assistant Professor at the University of Pittsburgh'''
[[Image:Yvonneklab.JPG|top|210px]]


'''Funding:''' Wellcome Trust<br>
'''Yvonne Yeung''' BDS Student
'''Project:''' Signal transduction by GSK-3beta in craniofacial development<br>
'''Summary:''' Congenital malformations of the craniofacial skeleton are among the most frequent developmental anomalies affecting live births. Common defects can include cleft palate and premature or delayed fusion of cranial sutures (craniosynostosis and cleidocranial dysplasia, respectively). GSK-3β, a kinase implicated in a number of important signaling pathways, is required for proper development of the craniofacial skeleton, including the palate and skull vault. We will use genetic analysis and novel protein regulation techniques to study the roles of GSK-3β in skull formation. Understanding this requirement will shed light on signalling events involved in craniofacial development and thus illuminate the mechanistic causes of these birth defects.


'''Project:''' Development of the palatine bone in ''Fuzzy'' mutant mice
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'''Dr. Lucy Smithers'''
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[[Image:Chiyoklab.JPG|top|210px]]


'''Funding:''' BBSRC-Selective Chemical Intervention in Biological Systems<br>
'''Chiyo Shimizu''' Overseas BDS student from Tokyo Medical & Dental University
'''Project:''' Using chemical tools to study Wnt signalling in neural development<br>
'''Summary:''' We are adapting a novel drug-dependent conditional system to the study of Wnt signalling. This project has two goals, first, to provide additional chemical tools for the study of Wnts and second, to use these tools to define the subcellular and temporal requirements of Wnts during patterning of the neurectoderm. We are developing tools in which activation of target proteins will be regulated temporally and spatially using small molecules specifically designed to have minimal off-target effects.


==Former Students==
'''Project:''' Studying the effect of Sostdel in the mammalian skull vault.
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'''Triona Bolger''' PhD Student
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'''Project:''' Roles of GSK-3 in neural crest migration and specification
[[Image:Sandraklab.JPG|top|210px]]


'''Warda Yakob''' MSc Student
'''Dr Rebecca Exley MBChB MRCS DOHNS PGDip (Med Ed)''' BDS Student
'''Project:''' Requirements for GSK-3 in palate development


'''Chisom Emecheta''' BSc Student
'''Project:''' Currently studying tracheal anomalies in the ''Fuzzy'' mutant mouse.
'''Project:''' Requirements for GSK-3 in palate development
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'''Siobhan McMahon''' Summer Student
'''Project:''' Requirement of Wisp1 in embryonic development


'''Sara Misra''' BSc Student
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'''Project:''' Osteoclastic bone resorption is a feature of skull development
Related Projects
 
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==Related Projects==


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Postdocs or students interested in working in the lab are welcome to discuss potential projects and fellowship applications. Informal inquiries may be made at any time to Dr. Karen Liu.
Postdocs or students interested in working in the lab are welcome to discuss potential projects and fellowship applications. Informal inquiries may be made at any time to Dr. Karen Liu.
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Revision as of 07:36, 4 September 2013

The Liu Lab Department of Craniofacial Biology Kings College London
Home Research Publications Protocols & Etc. Lab Members Contact Us Links


Principal Investigator



Dr. Karen J. Liu

Previous Positions
2007-present King's College London, Department of Craniofacial Development: Lecturer
2003-2006 Stanford University Medical School: Postdoctoral Fellow with Dr. Mike Longaker and Dr. Jerry Crabtree
1997-2003 University of California, Berkeley: PhD with Dr. Richard Harland
1995-1997 Columbia University College of Physicians & Surgeons: Technician with Dr. Argiris Efstratiadis
1992-1995 Pei Cobb Freed & Partners, Architects (formerly I.M.Pei & Partners)
1988-1992 Columbia College, Columbia University: BA, English/Architecture


Post-doc



Dr. Sandra Gonzalez Malagon

Funding: BBSRC
Project: Small molecule control of Wnt signal transduction
Summary: In this project, we have two broad goals: First, we are creating new alleles of β-catenin, using an approach called inducible stabilization. Second, we are exploiting reversible chemical control to study the genetic requirements of GSK-3 and β-catenin during neural crest migration. We hope that this project will provide a suite of broadly applicable tools for the study of Wnt signaling, as well as valuable insight into the mechanisms underlying neural crest migration.


PhD Students

Basil Yannakoudakis PhD Student

Project: Genetic Requirements in Craniofacial Skeletogenesis

Kshemendra Senarath-Yapa Overseas Phd

Undergraduate Students

William Barrell BDS Student

Project: Ossification of the Skull Vault

Yvonne Yeung BDS Student

Project: Development of the palatine bone in Fuzzy mutant mice


Chiyo Shimizu Overseas BDS student from Tokyo Medical & Dental University

Project: Studying the effect of Sostdel in the mammalian skull vault.

Dr Rebecca Exley MBChB MRCS DOHNS PGDip (Med Ed) BDS Student

Project: Currently studying tracheal anomalies in the Fuzzy mutant mouse.


Related Projects

Postdocs or students interested in working in the lab are welcome to discuss potential projects and fellowship applications. Informal inquiries may be made at any time to Dr. Karen Liu.

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