|
|
| (240 intermediate revisions by 2 users not shown) |
| Line 1: |
Line 1: |
| {{Template:KarenLiu}}
| |
|
| |
|
| <div style="padding: 10px; width: 730px; border: 0.5px solid #000000;">
| |
|
| |
| ==Principal Investigator==
| |
| '''Dr. Karen J. Liu'''
| |
|
| |
| [[Image:KarenLiu2.jpg|100px]]<br>
| |
|
| |
| '''2007-present''' King's College London, Department of Craniofacial Development: Lecturer<br>
| |
| '''2003-2006''' Stanford University Medical School: Postdoctoral Fellow with Dr. Mike Longaker and Dr. Jerry Crabtree<br>
| |
| '''1997-2003''' University of California, Berkeley: PhD with Dr. Richard Harland<br>
| |
| '''1995-1997''' Columbia University College of Physicians & Surgeons: Technician with Dr. Argiris Efstratiadis<br>
| |
| '''1992-1995''' Pei Cobb Freed & Partners, ''Architects'' (formerly I.M.Pei & Partners)<br>
| |
| '''1988-1992''' Columbia College, Columbia University: BA, English/Architecture<br>
| |
|
| |
| [http://www.nature.com/nature/journal/v446/n7131/full/7131xia.html Link to Nature "Authors" profile]
| |
|
| |
|
| |
|
| |
| ==Post-docs==
| |
|
| |
|
| |
| '''Dr. Heather Szabo-Rogers'''
| |
|
| |
| '''Funding:''' Wellcome Trust<br>
| |
| '''Project:''' Signal transduction by GSK-3beta in craniofacial development<br>
| |
| '''Summary:''' Congenital malformations of the craniofacial skeleton are among the most frequent developmental anomalies affecting live births. Common defects can include cleft palate and premature or delayed fusion of cranial sutures (craniosynostosis and cleidocranial dysplasia, respectively). GSK-3β, a kinase implicated in a number of important signaling pathways, is required for proper development of the craniofacial skeleton, including the palate and skull vault. We will use genetic analysis and novel protein regulation techniques to study the roles of GSK-3β in skull formation. Understanding this requirement will shed light on signalling events involved in craniofacial development and thus illuminate the mechanistic causes of these birth defects.
| |
|
| |
|
| |
| '''Dr. Lucy Smithers'''
| |
|
| |
| '''Funding:''' BBSRC-Selective Chemical Intervention in Biological Systems<br>
| |
| '''Project:''' Using chemical tools to study Wnt signalling in neural development<br>
| |
| '''Summary:''' We are adapting a novel drug-dependent conditional system to the study of Wnt signalling. This project has two goals, first, to provide additional chemical tools for the study of Wnts and second, to use these tools to define the subcellular and temporal requirements of Wnts during patterning of the neurectoderm. We are developing tools in which activation of target proteins will be regulated temporally and spatially using small molecules specifically designed to have minimal off-target effects.
| |
|
| |
|
| |
| ==Students==
| |
|
| |
| '''Triona Bolger''' PhD Student
| |
| '''Project:''' Roles of GSK-3 in neural crest migration and specification
| |
|
| |
| '''Warda Yakob''' MSc Student
| |
| '''Project:''' Requirements for GSK-3 in palate development
| |
|
| |
| '''Chisom Emecheta''' BSc Student
| |
| '''Project:''' Requirements for GSK-3 in palate development
| |
|
| |
| '''Siobhan McMahon''' Summer Student
| |
| '''Project:''' Requirement of Wisp1 in embryonic development
| |
|
| |
| ==Former Students==
| |
|
| |
| '''Triona Bolger''' PhD Student
| |
| '''Project:''' Roles of GSK-3 in neural crest migration and specification
| |
|
| |
| '''Warda Yakob''' MSc Student
| |
| '''Project:''' Requirements for GSK-3 in palate development
| |
|
| |
| '''Chisom Emecheta''' BSc Student
| |
| '''Project:''' Requirements for GSK-3 in palate development
| |
|
| |
| '''Siobhan McMahon''' Summer Student
| |
| '''Project:''' Requirement of Wisp1 in embryonic development
| |
|
| |
| '''Sara Misra''' BSc Student
| |
| '''Project:''' Osteoclastic bone resorption is a feature of skull development
| |
|
| |
| ==Related Projects==
| |
|
| |
| Postdocs or students interested in working in the lab are welcome to discuss potential projects and fellowship applications. Informal inquiries may be made at any time to Dr. Karen Liu.
| |
|
| |
|
| |
| </div>
| |
