Kemp

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How do internal and external environments control the transmission of cellular information? Our lab is investigating the mechanisms by which oxidative extracellular environments, such as those found in inflammation, and intracellular oxidation initiated by receptor ligation influence the ability of cells to signal properly. We are characterizing proteomic thiol oxidation through a strong synergy between computational and experimental methods. We use computational modeling to study how signaling networks may be regulated by changes in protein activities due to thiol modifications arising from intra- or extracellular produced reactive oxygen species. Experimentally, we are developing novel high-throughput biochemical assays to detect and quantify the S-glutathionylation and oxidation of proteins.
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How do internal and external environments control the transmission of cellular information? Our lab is investigating the mechanisms by which extracellular oxidation (by inflammation), and intracellular oxidation (such as initiated by receptor ligation) influence the ability of cells to signal properly. We are characterizing proteomic dynamics of thiol oxidation through a strong synergy between computational and experimental methods. We use computational modeling to study how signaling networks may be regulated by changes in protein activities due to thiol modifications arising from reactive oxygen species. Experimentally, we are developing novel high-throughput biochemical assays to detect and quantify the S-glutathionylation and oxidation of proteins.
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We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.
We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.

Revision as of 16:29, 20 August 2009

The Kemp Lab

Redox Systems Biology at Georgia Tech

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How do internal and external environments control the transmission of cellular information? Our lab is investigating the mechanisms by which extracellular oxidation (by inflammation), and intracellular oxidation (such as initiated by receptor ligation) influence the ability of cells to signal properly. We are characterizing proteomic dynamics of thiol oxidation through a strong synergy between computational and experimental methods. We use computational modeling to study how signaling networks may be regulated by changes in protein activities due to thiol modifications arising from reactive oxygen species. Experimentally, we are developing novel high-throughput biochemical assays to detect and quantify the S-glutathionylation and oxidation of proteins.

We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.


Image:2008-kemp-group.jpg
Kemp lab on the biotech quad, April 2008.

From left to right: John Vaughns, Ted Chen, Abby Hill, Catherine Rivet, Shreya Shukla, Melissa Kemp, Nnenna Adimora, Karen Shih

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