Kemp

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We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.
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How intracellular and extracellular environments control the transmission of cellular information is important for our understanding of cellular function. Our lab investigates the mechanisms by which extracellular oxidation (by inflammation), and intracellular oxidation (such as initiated by receptor ligation) influence the ability of cells to signal. We rely upon a strong synergy between computational and experimental methods to characterize proteomic dynamics of thiol oxidation. Because of the numerous biochemical reactions involved, we use computational modeling to investigate how signaling networks are regulated in the presence of reactive oxygen species by changes in activity and/or function of redox-sensitive proteins. Experimentally, we are developing novel high-throughput techniques for the detection and quantification of reversible protein oxidation.
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The lab research focuses on understanding at a systemic level how oxidative stress - induced internally by receptor-initiated ROS generation or by extracellular environment - leads to rapid but transient changes in signal transduction proteins through thiol modifications. Our lab relies on a strong synergy between computational and experimental work. We use computational modeling techniques to study how signaling networks may be regulated by changes in protein activities due to thiol modifications arising from intra- or extracellularly produced reactive oxygen species. Experimentally, we are developing novel high-throughput biochemical assays to detect and quantify the glutathionylation of proteins.
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We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.
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Current revision

The Kemp Lab

Redox Systems Biology at Georgia Tech

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How intracellular and extracellular environments control the transmission of cellular information is important for our understanding of cellular function. Our lab investigates the mechanisms by which extracellular oxidation (by inflammation), and intracellular oxidation (such as initiated by receptor ligation) influence the ability of cells to signal. We rely upon a strong synergy between computational and experimental methods to characterize proteomic dynamics of thiol oxidation. Because of the numerous biochemical reactions involved, we use computational modeling to investigate how signaling networks are regulated in the presence of reactive oxygen species by changes in activity and/or function of redox-sensitive proteins. Experimentally, we are developing novel high-throughput techniques for the detection and quantification of reversible protein oxidation.

We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.


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