Kemp

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
Current revision (19:13, 7 March 2011) (view source)
 
(11 intermediate revisions not shown.)
Line 2: Line 2:
<font size="2">
<font size="2">
-
How do cells transmit information, and how do internal and external environments control this transmission? Our lab is investigating the mechanisms by which oxidative extracellular environments (such as those found in inflammation) and intracellular oxidation (initiated by receptor ligation) influence the ability of cells to signal properly. We are characterizing the temporal control of proteins thiol modifications due to oxidation through a strong synergy between computational and experimental methods. We use computational modeling techniques to study how signaling networks may be regulated by changes in protein activities due to thiol modifications arising from intra- or extracellularly produced reactive oxygen species. Experimentally, we are developing novel high-throughput biochemical assays to detect and quantify the glutathionylation and oxidation of proteins.
+
How intracellular and extracellular environments control the transmission of cellular information is important for our understanding of cellular function. Our lab investigates the mechanisms by which extracellular oxidation (by inflammation), and intracellular oxidation (such as initiated by receptor ligation) influence the ability of cells to signal. We rely upon a strong synergy between computational and experimental methods to characterize proteomic dynamics of thiol oxidation. Because of the numerous biochemical reactions involved, we use computational modeling to investigate how signaling networks are regulated in the presence of reactive oxygen species by changes in activity and/or function of redox-sensitive proteins. Experimentally, we are developing novel high-throughput techniques for the detection and quantification of reversible protein oxidation.
<br> <br>
<br> <br>
We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.
We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.
<br>  
<br>  
<br><center>
<br><center>
-
[[Image:2008-kemp-group.jpg]]
+
[[Image:F10_Kemplab_photo.tif|400px]]
-
<br>
+
-
'''Kemp lab on the quad, April 2008.'''
+
-
<br>
+
-
''From left to right: John Vaughns, Ted Chen, Abby Hill, Catherine Rivet, Shreya Shukla, Melissa Kemp, Nnenna Adimora, Karen Shih''
+

Current revision

The Kemp Lab

Redox Systems Biology at Georgia Tech

Research        Publications        Lab Members        Positions        News        Links        Contact        Home      



How intracellular and extracellular environments control the transmission of cellular information is important for our understanding of cellular function. Our lab investigates the mechanisms by which extracellular oxidation (by inflammation), and intracellular oxidation (such as initiated by receptor ligation) influence the ability of cells to signal. We rely upon a strong synergy between computational and experimental methods to characterize proteomic dynamics of thiol oxidation. Because of the numerous biochemical reactions involved, we use computational modeling to investigate how signaling networks are regulated in the presence of reactive oxygen species by changes in activity and/or function of redox-sensitive proteins. Experimentally, we are developing novel high-throughput techniques for the detection and quantification of reversible protein oxidation.

We are located in the Wallace H. Coulter Department of Biomedical Engineering administered jointly between Georgia Tech and Emory University School of Medicine. The lab is physically located on the Georgia Tech campus in the Petit Institute for Bioengineering and Bioscience.


Personal tools