Kevin Matthew McKay Week 5

• BIOL398-03/S13:Week 5
• user:Kevin Matthew McKay

Genes

• GDH1
  • 2 Homo sapien Homologues:
    • 1NR1 and 1L1F
      • Deficiency in 1L1F causes hyperinsulinism/hymerammonemia syndrome
  • Expression is regulated by carbon sources
    • High expression in presence of glucose and ethanol

• GDH3
  • 2 Homo sapien Homologues:
    • 1NR1 and 1L1F
      • Deficiency in 1L1F causes hyperinsulinism/hymerammonemia syndrome
  • Expression regulated by carbon sources
    • High expression in presence of ethanol, repressed by glucose

• GDH2
  • Homo Sapien Homolog:
    • GLUD2
      • Deficiency causes hyperinsulinism
  • Expression regulated by nitrogen catabolite repression and intracellular ammonia levels

• GLN1
  • Homo sapien homologues:
  • 2OJW and 2QC8
    • Changes in activity of these genes has been linked to Alzheimer's disease
  • Expression regulated by nitrogen source and amino acid limitation

• GLT1
  • No Homo sapien homolog
  • Expression regulated by glutamate-mediated repression and GLN3P/GCN4P-mediated activation, availability of nitrogen and glutamate, and when amino acids are limiting, GLT1 expression is activated by GCN4P.

• L-GLutamate is involved in 56 pathways
• [- glutamate pathway]
• 

KEGG Pathway

• 
• All pf the genes in the reference pathway are in the yeast pathway on the website