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[[Kim:News | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''NEWS''' </font>]] | [[Kim:News | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''NEWS''' </font>]] | ||
[[Kim:Links | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''LINKS''' </font>]] | [[Kim:Links | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''LINKS''' </font>]] | ||
[[Kim: | [[Kim:Outreach | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''OUTREACH''' </font>]] [[Kim:Contact | <font face="trebuchet ms" size=3 style="color:#ffffff"> '''CONTACT''' </font>]] | ||
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<h3>Overview</h3> | <h3>Overview</h3> | ||
<font size=3>Our research spans the disciplinary boundaries between biomaterials, nanotechnology, and cell mechanobiology with an emphasis on their applications to tissue engineering and regenerative medicine. Through the use of multiscale fabrication and integration tools, we focus on the development and applications of biomimetic cell culture models and functional tissue engineering constructs for high-throughput drug screening, stem cell-based therapies, disease diagnostics, and medical device development. Using engineered microenvironments in combination with live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health. </font> | <font size=3>Our research spans the disciplinary boundaries between biomaterials, nanotechnology, and cell mechanobiology with an emphasis on their applications to tissue engineering and regenerative medicine. Through the use of multiscale (nano/micro/meso) fabrication and integration tools, we focus on the development and applications of biomimetic cell culture models and functional tissue engineering constructs for high-throughput drug screening, stem cell-based therapies, disease diagnostics, and medical device development. Using engineered microenvironments in combination with quantitative live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health. </font> | ||
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<h3>News</h3> | <h3>News</h3> | ||
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* | * D. Kim was awarded an Muscular Dystrophy Association (MDA) research grant to develop techniques for growing muscle for use in transplantation into a mouse model of Duchenne muscular dystrophy and was featured on the [http://mda.org/research/gaag/dmd-deok-ho-kim-phd MDA website] (Apr. 2013) | ||
* | * Daniel Lih has been awarded the Mary Gates Undergraduate Research Scholarship! | ||
* D. Kim | * Hee Seok Yang, who was a post doc in the lab, has accepted an offer to start as a faculty member at the Dankook University in Korea. Congratulations! (Feb. 2013) | ||
* D. Kim | * Alex Jiao, Nicole Trosper, and Justin Lee win the Outstanding Paper Award at the 2013 ASME Global Congress on Nano Engineering for Medicine and Biology (Feb. 2013) | ||
* D. Kim | * D. Kim was invited to join the editorial board of the [http://www.springer.com/engineering/electronics/journal/12213 Journal of Micro-Bio Robotics] as an Associate Editor (Jan. 2013) | ||
* D. Kim joins the honorary Editorial Board of the [http://www.dovepress.com/honorary-editorial-board-international-journal-of-nanomedicine-edboard5 International Journal of Nanomedicine] (Jan. 2013) | |||
* D. Kim joins the Editorial Board of the [http://digital-library.theiet.org/content/journals/iet-nbt IET Nanobiotechnology Journal] (Jan. 2013) | |||
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<h3>Featured Publications</h3> | <h3>Featured Publications</h3> | ||
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* A non-transcriptional role for HIF-1α as a direct inhibitor of DNA replication, Science Signaling, vol. 6, pp. ra10, 2013. [http://stke.sciencemag.org/content/vol6/issue262/cover.dtl '''(Featured as a Cover Article)'''] [http://stke.sciencemag.org/cgi/content/full/sigtrans;6/262/ra10 Article] [http://stke.sciencemag.org/cgi/content/full/sigtrans;6/262/pc5/DC1 Podcast]<br> | |||
* Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration, Integrative Biology, Vol. 4, Issue 9,pp. 1019-1033, 2012 [http://pubs.rsc.org/en/journals/journalissues/ib#!issueid=ib004009&type=current&issnprint=1757-9694 '''(Featured Cover Article)'''] [http://pubs.rsc.org/en/content/articlelanding/2012/ib/c2ib20067h Article]<br> | * Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration, Integrative Biology, Vol. 4, Issue 9,pp. 1019-1033, 2012 [http://pubs.rsc.org/en/journals/journalissues/ib#!issueid=ib004009&type=current&issnprint=1757-9694 '''(Featured Cover Article)'''] [http://pubs.rsc.org/en/content/articlelanding/2012/ib/c2ib20067h Article]<br> | ||
* Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors, Science Signaling, vol. 5, issue 227, p. ra41, 2012. [http://stke.sciencemag.org/content/vol5/issue227/cover.dtl '''(Featured as a Cover Article)'''] [http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/227/ra41 Article] | * Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors, Science Signaling, vol. 5, issue 227, p. ra41, 2012. [http://stke.sciencemag.org/content/vol5/issue227/cover.dtl '''(Featured as a Cover Article)'''] [http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/227/ra41 Article] | ||
* Engineering neuronal growth cone to promote axon regeneration over inhibitory molecules, Proceedings of the National Academy of Sciences USA, vol. 108, pp. 5057-5062, 2011. [http://www.pnas.org/content/early/2011/03/03/1011258108.full.pdf+html Article]<BR> | * Engineering neuronal growth cone to promote axon regeneration over inhibitory molecules, Proceedings of the National Academy of Sciences USA, vol. 108, pp. 5057-5062, 2011. [http://www.pnas.org/content/early/2011/03/03/1011258108.full.pdf+html Article]<BR> | ||
* Biomimetic nanopatterns as enabling tools for analysis and control of live cells, Advanced Materials, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20803528 Pubmed], [http://www.hubmed.org/display.cgi?uids=20803528 Hubmed] <BR> | * Biomimetic nanopatterns as enabling tools for analysis and control of live cells, Advanced Materials, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20803528 Pubmed], [http://www.hubmed.org/display.cgi?uids=20803528 Hubmed] <BR> | ||
* Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs, Proceedings of National Academy of Sciences USA, vol.107, pp. 565-570, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20018748 | * Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs, Proceedings of National Academy of Sciences USA, vol.107, pp. 565-570, 2010. [http://www.ncbi.nlm.nih.gov/pubmed/20018748 Article] [http://www.nibib.nih.gov/HealthEdu/eAdvances/30July10 '''(Highlighted in the National Institute of Biomedical Imaging and Bioengineering)]''' | ||
* Microengineered platforms for cell mechanobiology, Annual Review of Biomedical Engineering, vol. 11, pp.203-233, 2009. [http://www.ncbi.nlm.nih.gov/pubmed/19400708 Article] | |||
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Our sponsors:<br> | |||
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[http://www2.clustrmaps.com/user/a76c219e http://www2.clustrmaps.com/stats/maps-no_clusters/www.openwetware.org-wiki-Kim-thumb.jpg] | |||
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Revision as of 12:44, 4 May 2013
OverviewOur research spans the disciplinary boundaries between biomaterials, nanotechnology, and cell mechanobiology with an emphasis on their applications to tissue engineering and regenerative medicine. Through the use of multiscale (nano/micro/meso) fabrication and integration tools, we focus on the development and applications of biomimetic cell culture models and functional tissue engineering constructs for high-throughput drug screening, stem cell-based therapies, disease diagnostics, and medical device development. Using engineered microenvironments in combination with quantitative live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health. |
News
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Featured Publications
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Our sponsors:
http://www2.clustrmaps.com/stats/maps-no_clusters/www.openwetware.org-wiki-Kim-thumb.jpg
