Klapperich Lab

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'''Klapperich Laboratory
 
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''' at Boston University'''
 
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<h3>This page is under construction, please visit us at [http://www.klapperichlab.org www.klapperichlab.org] </h3>
 
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==Lab Members==
 
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Prof. Catherine Klapperich<br>
 
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[http://people.bu.edu/jdk21 Jessica Kaufman]<br>
 
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Arpita Bhattacharyya<br>
 
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Nathan Spencer<br>
 
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Maria Dominika Kulinski<br>
 
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Benjamin Kooy<br>
 
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David Altman<br>
 
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Eben Tessari<br>
 
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Amy VanHove<br>
 
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Dr. Cassandra Noack<br>
 
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==[[Klapperich_Lab:Protocols|Lab Specific Protocols]]==
 
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<br>
 
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<font color="#2F9258"><font size="2"><strong>Archival Journal Articles</strong></font><br /></font><br />
 
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<biblio>
 
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#paper1 pmid=16620959
 
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#paper2 pmid=16448052
 
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#paper3 pmid=15159079
 
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#paper4 J. Song, J. Chen, C.M. Klapperich, V. Eng and C.R. Bertozzi,''Functional glass slides for in vitro evaluation of interactions between bone cells and mineral-binding ligands,'' Journal of Materials Chemistry,14, 2643-2648, (2004).
 
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#paper5 C.M. Klapperich, K. Komvopoulos and L. Pruitt, ''Nanoindentation Experiments to Probe the Surface Mechanical Properties of Plasma Treated Polyethylenes,'' Journal of Materials Research, Vol.17 (2), (2002).
 
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#paper6 pmid=15348272
 
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#paper7 Klapperich, C., Komvopoulos, K., and Pruitt, L., ''Nanomechanical Properties of Polymers Determined From Nanoindentation Experiments,'' Journal of Tribology, ASME Trans., Vol. 123, No. 3, pp. 624-631, (2001).
 
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#paper8 pmid=11340595
 
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#paper9 pmid=10634955
 
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#paper10 C. Klapperich, K. Komvopoulos, and L. Pruitt, ''Tribological Properties and Microstructural Evolution of Ultra-High Molecular Weight Polyethylene,'' Journal of Tribology, 121(2) April (1999).
 
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#paper11 pmid=10537267
 
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</biblio>
 
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<div style="padding: 10px; width: 720px; border: 5px solid #000099;"><h3><font color=#2F9258>Research</font></h3>
 
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The Biomedical Materials Research Laboratory is focused on materials research activities in the broad areas of tissue engineering and biomedical device design. The laboratory is equipped for polymer and hydrogel synthesis, microfluidic device rapid prototyping, fabrication of tissue engineering scaffold materials, molecular analysis and tissue culture. The laboratory houses a dynamic mechanical analyzer for time and temperature sensitive testing of gel and polymer macroscale mechanical properties. This facility is a fully functional laboratory for integrated mechanical, chemical and biological testing of biomaterials. The laboratory is adjacent to the shared bio-micro/nanofabrication center. This cleanroom contains a mask aligner, AFM, DekTak Profilometer, e-beam evaporator and a spin coater. The lab also maintains a Hysitron Triboscope Nanoindentation Instrument located in the Low Vibration Area of the Photonics Center. Laboratory projects include experiments and modeling of the contact problem for nanoscale probes on soft hydrated biomaterials, cell-biomaterial interactions in tissue engineering materials, and diagnostic microfluidic device design.
 
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<div><font color=#2F9258><font size="2"><strong>Recent announcements
 
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*'''03/01/06''' -
 
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*'''01/09/06''' -
 
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*'''01/09/06''' -
 
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__NOTOC__
 
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<br>
 
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Thanks to [[BE Board]] for this template
 
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[[Image:klapperichlab.jpg]]
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<h3>Lab Members</h3>
<h3>Lab Members</h3>
__NOTOC__
__NOTOC__
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• [[User:matsudaira|Paul Matsudaira]]<br>
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• [[Klapperich_Lab|Prof. Catherine Klapperich]]<br>
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• [[Klapperich_Lab:Students|Students]]<br>
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. [[Klapperich_Lab:Collaborators|Collaborators]]<br>
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• [[Matsudaira:Students|Students]]<br>
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<h3>Content</h3>
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• [[Matsudaira:Researchers|Researchers]]<br>
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• [[Klapperich_Lab:Projects|Projects]]<br>
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• [[Matsudaira:Admin|Administrators & Alumni]]<br>
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• [[Klapperich_Lab:Equipment|Equipment]]<br>
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• [[Matsudaira:Keck|Keck Microscope Facility]]<br>
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• [[Klapperich_Lab:Protocols|Protocols]]<br>
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• [[Klapperich_Lab:Publications|Publications]]<br>
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• [[Klapperich_Lab:Handbook|Handbook]]<br>
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<h3>[[Matsudaira:Calendar|Calendar]]</h3>
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<h3>[[Klapperich_Lab:News|News]]</h3>
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<h3>Content</h3>
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• [[Matsudaira:Projects|Projects]]<br>
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• [[Matsudaira:Equipment|Equipment]]<br>
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• [[Matsudaira:Materials|Materials]]<br>
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• [[Matsudaira:Protocols|Protocols]]<br>
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• [[Matsudaira:Publications|Publications]]<br>
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• [http://harp.bioimaging.wi.mit.edu/bicwiki/index.php?title=Matsu Internal Wiki]<br>
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• [[Matsudaira:Handbook|handbook]]<br>
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<h3>[[Matsudaira:News|News]]</h3>
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[http://www.jove.com/index/Details.stp?ID=664 January 2008: Visual Protocols now Online at JOVE!]<br>
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<h3>Contact Us</h3>
<h3>Contact Us</h3>
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Whitehead Institute<Br>
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Department of Biomedical Engineering<Br>
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9 Cambridge Center<br>
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44 Cummington Street<br>
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Cambridge, MA 02142 <br>
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Boston, MA 02115 <br>
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<b>Office:</b> WI 660<br>
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<b>Student Office:</b> ERB 725<br>
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<b>Phone:</b> (617) 258-9772<br>
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<b>Phone:</b> (617) 358-0253<br>
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<b>Fax: </b>(617) 258-7226<br>
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<b>Fax: </b> (617) 353-6766<br>
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<b>Lab:</b> ERB 720<br>
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<b>Phone:</b> (617) 358-3409<br>
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http://openwetware.org/wiki/Klapperich_Lab:Notebook
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Our research is focused in two areas: the mechanics of the cytoskeleton, and miniaturized ultra-fast bioanalytical devices. We also concentrate on development of advanced imaging and informatics methods through the associated [http://bioimaging.wi.mit.edu/ Whitehead-MIT Bioimaging Center.]
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The Biomedical Microdevices and Microenvironments Laboratory (BMML) is focused on the design and engineering of manufacturable, disposable microfluidic systems for low-cost point-of-care molecular diagnostics. We are currently working on devices for the detection of infectious diarrhea, influenza and MRSA.
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We are also studying the interactions between cells and synthetic microenvironments. Specifically, we are interested in building culture systems in vitro that mechanically mimic the physiological environment. These synthetic microenvironments are intended for use in diagnostics, high throughput drug screening, and to enable previously impossible basic science studies. Currently we have projects aimed at recapitulating the microenvironments of the breast, cochlea and neural tissue.
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Current revision

Image:klapperichlab.jpg

Lab Members

Prof. Catherine Klapperich
Students
. Collaborators

Content

Projects
Equipment
Protocols
Publications
Handbook

News

January 2008: Visual Protocols now Online at JOVE!

Contact Us

Department of Biomedical Engineering
44 Cummington Street
Boston, MA 02115

Student Office: ERB 725
Phone: (617) 358-0253
Fax: (617) 353-6766
Lab: ERB 720
Phone: (617) 358-3409
http://openwetware.org/wiki/Klapperich_Lab:Notebook


The Biomedical Microdevices and Microenvironments Laboratory (BMML) is focused on the design and engineering of manufacturable, disposable microfluidic systems for low-cost point-of-care molecular diagnostics. We are currently working on devices for the detection of infectious diarrhea, influenza and MRSA.

We are also studying the interactions between cells and synthetic microenvironments. Specifically, we are interested in building culture systems in vitro that mechanically mimic the physiological environment. These synthetic microenvironments are intended for use in diagnostics, high throughput drug screening, and to enable previously impossible basic science studies. Currently we have projects aimed at recapitulating the microenvironments of the breast, cochlea and neural tissue.

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