Klapperich Lab

Klapperich Laboratory at Boston University This page is under construction, please visit us at www.klapperichlab.org

Lab Members Catherine Klapperich Jessica Kaufman[1] Arpita Bhattacharyya Archival Journal Articles 1. Jaworski, J. and C.M. Klapperich, “Differential Expression of Fibroblast Remodeling Factors on Two- and Three-Dimensional Collagen-Glycosaminoglycan Substrates,” <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16620959&query_hl=1&itool=pubmed_docsum">Biomaterials, Volume 27, Issue 23, pp. 4212-4220, (2006).</a> 2. Bhattacharyya, A. and C.M. Klapperich, “Thermoplastic microfluidic device for on-chip purification of nucleic acids for disposable diagnostics,” <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16448052&query_hl=1&itool=pubmed_docsum" target="">Analytical Chemistry, 78(3): p. 788-92. (2006). </a> 3. C.M. Klapperich and C.R. Bertozzi, “Global Gene Expression of Cells Attached to a Tissue Engineering Scaffold,” <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15159079&query_hl=1&itool=pubmed_docsum" target="">Biomaterials, Volume 25, Issue 25, pp. 5631-5641, (2004). </a> 4. J. Song, J. Chen, C.M. Klapperich, V. Eng and C.R. Bertozzi, "Functional glass slides for in vitro evaluation of interactions between bone cells and mineral-binding ligands," Journal of Materials Chemistry,14, 2643-2648, (2004). 5. C.M. Klapperich, K. Komvopoulos and L. Pruitt, “Nanoindentation Experiments to Probe the Surface Mechanical Properties of Plasma Treated Polyethylenes,” Journal of Materials Research, Vol.17 (2), (2002). 6. Klapperich, C., Pruitt, L., and Komvopoulos, K., “Chemical and Biological Characteristics of Low-Temperature Plasma Treated Ultra-High Molecular Weight Polyethylene for Biomedical Applications,” <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15348272&query_hl=1&itool=pubmed_docsum">Journal of Materials Science: Materials in Medicine, Vol. 12, No. 6, pp. 549-556, (2001).</a> 7. Klapperich, C., Komvopoulos, K., and Pruitt, L., “Nanomechanical Properties of Polymers Determined From Nanoindentation Experiments,” Journal of Tribology, ASME Trans., Vol. 123, No. 3, pp. 624-631, (2001). 8. Niedzwiecki, S, Klapperich, C, Short, J, Jani, S, Ries, M, Pruitt, L., “Comparison of three joint simulator wear debris isolation techniques: acid digestion, base digestion, and enzyme cleavage,”<ahref="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11340595&query_hl=1&itool=pubmed_docsum" target="">Journal of Biomedical Materials Research, 56(2) 245-9, (2001). </a>9. C.M. Klapperich, S. Niedzwiecki, M. Ries, and L. Pruitt, "Fluid Sorption of Orthopedic Grade Ultra High Molecular Weight Polyethylene in a Serum Environment is Affected by the Surface Area and Sterilization Method," <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10634955&query_hl=1&itool=pubmed_docsum" target="">Journal of Biomedical Materials Research (Applied Biomaterials) 53, 73-75, (2000). </a> 10. C. Klapperich, K. Komvopoulos, and L. Pruitt, "Tribological Properties and Microstructural Evolution of Ultra-High Molecular Weight Polyethylene," Journal of Tribology, 121(2) April (1999). 11. C. Klapperich, J. Graham, L. Pruitt, and M.Ries, "Failure of a Metal-Metal Total Hip Arthroplasty from Progressive Osteolysis," <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10537267&query_hl=1&itool=pubmed_docsum">Journal of Arthroplasty, 14(7), (1999).</a>

Research

The Biomedical Materials Research Laboratory is focused on materials research activities in the broad areas of tissue engineering and biomedical device design. The laboratory is equipped for polymer and hydrogel synthesis, microfluidic device rapid prototyping, fabrication of tissue engineering scaffold materials, molecular analysis and tissue culture. The laboratory houses a dynamic mechanical analyzer for time and temperature sensitive testing of gel and polymer macroscale mechanical properties. This facility is a fully functional laboratory for integrated mechanical, chemical and biological testing of biomaterials. The laboratory is adjacent to the shared bio-micro/nanofabrication center. This cleanroom contains a mask aligner, AFM, DekTak Profilometer, e-beam evaporator and a spin coater. The lab also maintains a Hysitron Triboscope Nanoindentation Instrument located in the Low Vibration Area of the Photonics Center. Laboratory projects include experiments and modeling of the contact problem for nanoscale probes on soft hydrated biomaterials, cell-biomaterial interactions in tissue engineering materials, and diagnostic microfluidic device design.

Recent announcements

• 03/01/06 -
• 01/09/06 -
• 01/09/06

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