Klapperich Lab

Klapperich Laboratory at Boston University This page is under construction, please visit us at www.klapperichlab.org

Lab Members Prof. Catherine Klapperich Jessica Kaufman Arpita Bhattacharyya Nathan Spencer Maria Dominika Kulinski Benjamin Kooy David Altman Eben Tessari Amy VanHove Dr. Cassandra Noack Lab Specific Protocols Archival Journal Articles Jaworski J and Klapperich CM. Fibroblast remodeling activity at two- and three-dimensional collagen-glycosaminoglycan interfaces. Biomaterials. 2006 Aug;27(23):4212-20. DOI:10.1016/j.biomaterials.2006.03.026 | Bhattacharyya A and Klapperich CM. Thermoplastic microfluidic device for on-chip purification of nucleic acids for disposable diagnostics. Anal Chem. 2006 Feb 1;78(3):788-92. DOI:10.1021/ac051449j | Klapperich CM and Bertozzi CR. Global gene expression of cells attached to a tissue engineering scaffold. Biomaterials. 2004 Nov;25(25):5631-41. DOI:10.1016/j.biomaterials.2004.01.025 | J. Song, J. Chen, C.M. Klapperich, V. Eng and C.R. Bertozzi,Functional glass slides for in vitro evaluation of interactions between bone cells and mineral-binding ligands, Journal of Materials Chemistry,14, 2643-2648, (2004). C.M. Klapperich, K. Komvopoulos and L. Pruitt, Nanoindentation Experiments to Probe the Surface Mechanical Properties of Plasma Treated Polyethylenes, Journal of Materials Research, Vol.17 (2), (2002). Klapperich C, Pruitt L, and Komvopoulos K. Chemical and biological characteristics of low-temperature plasma treated ultra-high molecular weight polyethylene for biomedical applications. J Mater Sci Mater Med. 2001 Jun;12(6):549-56. DOI:10.1023/a:1011232032413 | Klapperich, C., Komvopoulos, K., and Pruitt, L., Nanomechanical Properties of Polymers Determined From Nanoindentation Experiments, Journal of Tribology, ASME Trans., Vol. 123, No. 3, pp. 624-631, (2001). Niedzwiecki S, Klapperich C, Short J, Jani S, Ries M, and Pruitt L. Comparison of three joint simulator wear debris isolation techniques: acid digestion, base digestion, and enzyme cleavage. J Biomed Mater Res. 2001 Aug;56(2):245-9. DOI:10.1002/1097-4636(200108)56:2<245::aid-jbm1091>3.0.co;2-t | Klapperich C, Niedzwiecki S, Ries M, and Pruitt L. Fluid sorption of orthopedic grade ultrahigh molecular weight polyethylene in a serum environment is affected by the surface area and sterilization method. J Biomed Mater Res. 2000;53(1):73-5. DOI:10.1002/(sici)1097-4636(2000)53:1<73::aid-jbm10>3.0.co;2-a | C. Klapperich, K. Komvopoulos, and L. Pruitt, Tribological Properties and Microstructural Evolution of Ultra-High Molecular Weight Polyethylene, Journal of Tribology, 121(2) April (1999). Klapperich C, Graham J, Pruitt L, and Ries MD. Failure of a metal-on-metal total hip arthroplasty from progressive osteolysis. J Arthroplasty. 1999 Oct;14(7):877-81. DOI:10.1016/s0883-5403(99)90042-6 | Research The Biomedical Materials Research Laboratory is focused on materials research activities in the broad areas of tissue engineering and biomedical device design. The laboratory is equipped for polymer and hydrogel synthesis, microfluidic device rapid prototyping, fabrication of tissue engineering scaffold materials, molecular analysis and tissue culture. The laboratory houses a dynamic mechanical analyzer for time and temperature sensitive testing of gel and polymer macroscale mechanical properties. This facility is a fully functional laboratory for integrated mechanical, chemical and biological testing of biomaterials. The laboratory is adjacent to the shared bio-micro/nanofabrication center. This cleanroom contains a mask aligner, AFM, DekTak Profilometer, e-beam evaporator and a spin coater. The lab also maintains a Hysitron Triboscope Nanoindentation Instrument located in the Low Vibration Area of the Photonics Center. Laboratory projects include experiments and modeling of the contact problem for nanoscale probes on soft hydrated biomaterials, cell-biomaterial interactions in tissue engineering materials, and diagnostic microfluidic device design. Recent announcements 03/01/06 - 01/09/06 - 01/09/06 - Thanks to BE Board for this template Lab Members • Paul Matsudaira • Students • Researchers • Administrators & Alumni • Keck Microscope Facility Calendar Content • Projects • Equipment • Materials • Protocols • Publications • Internal Wiki • handbook News Contact Us Whitehead Institute 9 Cambridge Center Cambridge, MA 02142 Office: WI 660 Phone: (617) 258-9772 Fax: (617) 258-7226 Our research is focused in two areas: the mechanics of the cytoskeleton, and miniaturized ultra-fast bioanalytical devices. We also concentrate on development of advanced imaging and informatics methods through the associated Whitehead-MIT Bioimaging Center.