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The Klinke Lab @ West Virginia University

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Dr. David J. Klinke II is currently an assistant professor in the Department of Chemical Engineering in the WVU College of Engineering and Mineral Resources (CEMR). In addition to his position in Chemical Engineering, he is an Adjunct Assistant Professor of Microbiology, Immunology, and Cell Biology in the WVU School of Medicine. He received his Ph.D. in Chemical Engineering from Northwestern University in 1998, where his research focus was on developing detailed chemical kinetic models of Fischer-Tropsch synthesis. From 1999 until joining WVU in 2006, he provided strategic direction in developing mathematical models of immunologic and metabolic diseases for one of the commercial leaders in the emerging field of systems biology: Entelos, Inc. His current research applies the computational tools of engineering analysis to biological problems in immunology and cellular signal transduction. Recent publications provide examples of this research.

This isn't your parent's chemical engineering.

Here at West Virginia University, Prof. Klinke’s research program builds on his experience developing large-scale mathematical models of human pathophysiology. Building mathematical models of disease is a collaborative effort between chemical engineers and life scientists to extract information from the scientific literature to define, calibrate, and validate these models experimentally. Understanding biology via computational modeling is very similar to traditional research in chemical engineering. At the most basic level, chemical engineering is a field in which basic science data is integrated into computational frameworks. Traditionally, chemical engineering integrates basic chemistry data into computational models to develop new chemical products or processes. Moving forward into the 21st Century, there is an urgent need for integrating basic biology data into computational frameworks to understand disease pathophysiology and aid in the rational design of novel therapeutics. It is our goal to become leaders in the field of chemical engineering by fulfilling this urgent need.

Our research integrates the Department of Chemical Engineering in the College of Engineering and Mineral Resources and Department of Microbiology, Immunology & Cell Biology in the School of Medicine at West Virginia University. The wet lab is located on the Health Sciences campus while the computational lab is located on the Evansdale campus. The Evansdale campus is less than one mile west of the Health Sciences campus and connected by the Personal Rapid Transit system that provides free transportation between the two campuses.

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