Klinke:Publications

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The Klinke Lab @ West Virginia University

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Publications


  1. Klinke DJ 2nd and Broadbelt LJ, Mechanism Reduction during Computer Generation of Compact Reaction Models, AIChE J. 1997; 43:1828-1837. [NWU-1]
  2. Klinke DJ 2nd, Wilke S, and Broadbelt LJ, A Theoretical Study of Carbon Chemisorption on Ni(111) and Co(0001) Surfaces, J. Catal. 1998; 178:540-554.

    [NWU-2]

  3. Klinke DJ 2nd and Broadbelt LJ, Construction of a Mechanistic Model of Fischer-Tropsch Synthesis on Ni(111) and Co(0001) Surfaces, Chem. Eng. Sci. 1999; 54:3379-3389.

    [NWU-3]

    The first application of a rule-based reaction network generation algorithm to heterogeneous catalytic chemistry.

  4. Klinke DJ 2nd, Dooling DJ, and Broadbelt LJ, A Theoretical Study of Methylidyne Chemisorption on Ni(111) and Co(0001) Surfaces; Surf. Sci. 1999; 425:334-342.

    [NWU-4]

  5. Klinke DJ 2nd and Broadbelt LJ, A Theoretical Study of Hydrogen Chemisorption on Ni(111) and Co(0001) Surfaces, Surf. Sci. 1999; 429:169-177.

    [NWU-5]

  6. Broadbelt LJ and Klinke DJ 2nd, Kinetics of Catalyzed Reactions – D (Heterogeneous) in Encyclopedia of Catalysis, Istvan T. Horvath (Editor-in-Chief), ISBN 0-471-24183-0, pp. 4772, December 2002.

    [NWU-6]

  7. Klinke DJ 2nd. . pmid:16448670. PubMed HubMed [WVU-1]
  8. Klinke DJ 2nd. . pmid:17030902. PubMed HubMed [WVU-2]
  9. Klinke DJ 2nd. . pmid:17457675. PubMed HubMed [WVU-3]
  10. Klinke DJ 2nd. . pmid:18046647. PubMed HubMed [WVU-4]
    Provides a glimpse of the size and complexity of the proprietary PhysioLab models developed by Entelos, Inc.

  11. Klinke DJ 2nd. . pmid:18167535. PubMed HubMed [WVU-5]
    Evaluates the conventional wisdom regarding the extent of beta cell destruction required before presenting with symptoms of type 1 diabetes.

  12. Klinke DJ 2nd, Ustyugova IV, Brundage KM, and Barnett JB. . pmid:18281385. PubMed HubMed [WVU-6]
    Finds that our ability to observe significant biological events is limited by the signal-to-noise characteristics of the assays that we use to observe cellular responses.

  13. Klinke DJ 2nd. . pmid:19513847. PubMed HubMed [WVU-7]
    Develops and validates a dimensionless number for the ratio of insulin production and insulin-dependent glucose metabolism in humans.

  14. Klinke DJ 2nd and Brundage KM. . pmid:19582872. PubMed HubMed [WVU-8]
    Provides a tutorial for using R/Bioconductor to process flow cytometry data.

  15. Leski TA, Caswell CC, Pawlowski M, Klinke DJ, Bujnicki JM, Hart SJ, and Lukomski S. . pmid:19767469. PubMed HubMed [WVU-9]
    Describes an approach to distinguish with confidence among B. anthracis strains using variability in collagen-like proteins. This addresses one of the problems with finding the perpetrators of the B. anthracis attacks on the U.S. Capital in 2001.

  16. Klinke DJ 2nd. . pmid:19900289. PubMed HubMed [WVU-10]
    This is a highly accessed publication in BMC Bioinformatics

  17. Klinke DJ 2nd. . pmid:20179207. PubMed HubMed [WVU-11]
    This publication was highlighted as Research News on the Physical Sciences in Oncology website hosted by the National Cancer Institute.

  18. Finley SD, Gupta D, Cheng N, and Klinke DJ 2nd. . pmid:20479776. PubMed HubMed [WVU-12]
    This publication uses an empirical Bayesian approach to infer the contributions of different mechanisms that regulate IL-12 signaling in naïve CD4+ T cells derived from Balb/c mice.

  19. Kulkarni YM, Suarez V, and Klinke DJ 2nd. . pmid:20550684. PubMed HubMed [WVU-13]
    This publication uses a proteomics workflow that includes 2D-gel electrophoresis and MALDI-TOF MS peptide mass fingerprinting to identify predominant pathways in two breast cancer cell models.

  20. Klinke DJ 2nd, A multiscale systems perspective on cancer, immunotherapy, and Interleukin-12, Molecular Cancer 2010 Sept 15; 9:242.

    [WVU-14]

  21. Klinke DJ 2nd, Inferring the dynamic role of beta cell function in the natural history of diabetes using mathematical prototypes, 2010 submitted.

    [WVU-15]

All Medline abstracts: PubMed HubMed


Patents and Patent Applications

  1. Defranoux, N.A.; Dubnicoff, T.B.; Klinke, D.J.; Lewis, A.K.; Paterson, T.S.; Ramanujan, S.; Shoda, L.K.M.; Soderstrom, K.P.; Struemper, H.K.; "Method and apparatus for computer modeling a joint", US Patent #6,862,561.
  2. Kelly, S.D.; Klinke, D.J.; Leong, C.; Lewis, A.K.; Okino, M.S.; Paterson, T.S.; Shoda, L.K.M.; Stokes, C.; Struemper, H.K.; "Method and apparatus for computer modeling of an adaptive immune response", US Patent Application #10/154,123.
  3. Friedrich, C.M.; Kansal, A.; Klinke, D.J.; Michelson, S.G.; Paterson, T.S.; Polidori, D.; Trimmer, J.; Wennerberg, L.G.; "Defining Virtual Patient Populations", US Patent Application #11/346,990.
  4. Defranoux, N.A.; Dubnicoff, T.B.; Klinke, D.J.; Lewis, A.K.; Paterson, T.S.; Ramanujan, S.; Shoda, L.K.M.; Soderstrom, K.P.; Struemper, H.K.; "Method and apparatus for computer modeling a joint", US Patent #7,472,050.
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