Kofuji Lab - Revision history

http://www.openwetware.org/index.php?title=Kofuji_Lab&feed=atom&action=history Kofuji Lab - Revision history 2013-05-20T16:56:18Z Revision history for this page on the wiki MediaWiki 1.13.2 http://www.openwetware.org/index.php?title=Kofuji_Lab&diff=391010&oldid=prev Paulo Kofuji at 02:46, 13 February 2010 2010-02-13T02:46:04Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 02:46, 13 February 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 2:</td> <td colspan="2" class="diff-lineno">Line 2:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{|   </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{|   </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|- valign="top"</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|- valign="top"</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>|width=945px class="MainPageBG" style="border: 5px solid #<del class="diffchange diffchange-inline">55778D</del>; color: #000000; background-color: #FFFFFF"|</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>|width=945px class="MainPageBG" style="border: 5px solid #<ins class="diffchange diffchange-inline">000000</ins>; color: #000000; background-color: #FFFFFF"|</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><div style="padding: .4em .9em .9em"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><div style="padding: .4em .9em .9em"></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>  </table>

Paulo Kofuji http://www.openwetware.org/index.php?title=Kofuji_Lab&diff=390999&oldid=prev Paulo Kofuji at 02:38, 13 February 2010 2010-02-13T02:38:50Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 02:38, 13 February 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 2:</td> <td colspan="2" class="diff-lineno">Line 2:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{|   </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{|   </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|- valign="top"</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>|- valign="top"</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>|width=<del class="diffchange diffchange-inline">940px </del>class="MainPageBG" style="border: 5px solid #55778D; color: #000000; background-color: #FFFFFF"|</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>|width=<ins class="diffchange diffchange-inline">945px </ins>class="MainPageBG" style="border: 5px solid #55778D; color: #000000; background-color: #FFFFFF"|</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><div style="padding: .4em .9em .9em"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><div style="padding: .4em .9em .9em"></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>  </table>

Paulo Kofuji http://www.openwetware.org/index.php?title=Kofuji_Lab&diff=390998&oldid=prev Paulo Kofuji at 02:37, 13 February 2010 2010-02-13T02:37:59Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 02:37, 13 February 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Kofuji}}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Kofuji}}</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">{|  </ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">|- valign="top"</ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">|width=940px class="MainPageBG" style="border: 5px solid #55778D; color: #000000; background-color: #FFFFFF"|</ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><div style="padding: .4em .9em .9em"></ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Kofuji Lab static webpage [http://www2.neuroscience.umn.edu/paulowebsite/]'''</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Kofuji Lab static webpage [http://www2.neuroscience.umn.edu/paulowebsite/]'''</div></td></tr>  </table>

Paulo Kofuji http://www.openwetware.org/index.php?title=Kofuji_Lab&diff=390916&oldid=prev Paulo Kofuji at 22:11, 12 February 2010 2010-02-12T22:11:10Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 22:11, 12 February 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Kofuji}}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Kofuji}}</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''Kofuji Lab <del class="diffchange diffchange-inline">Static </del>webpage [http://www2.neuroscience.umn.edu/paulowebsite/]'''</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>'''Kofuji Lab <ins class="diffchange diffchange-inline">static </ins>webpage [http://www2.neuroscience.umn.edu/paulowebsite/]'''</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>  </table>

Paulo Kofuji http://www.openwetware.org/index.php?title=Kofuji_Lab&diff=390869&oldid=prev Paulo Kofuji at 20:44, 12 February 2010 2010-02-12T20:44:45Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 20:44, 12 February 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 4:</td> <td colspan="2" class="diff-lineno">Line 4:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Research in our laboratory uses various molecular, genetic and electrophysiological techniques to study the <del class="diffchange diffchange-inline">functional roles </del>of potassium channels in the nervous system with particular emphasis on the inwardly rectifying (Kir) channels. Molecular techniques are used to study the cellular and subcellular distribution of Kir channels and their functional and biophysical properties on expression in heterologous systems such as Xenopus oocytes or mammalian cell lines. In addition, the laboratory has generated mice carrying targeted deletions of specific Kir channel genes to determine their function "in vivo". Among these, the Kir4.1 channel "knock out" mice display motor, sensory deficits and shorter life span. We are currently investigating the role of Kir4.1 channels in regulation of extracellular potassium in retina and other tissues.  </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Research in our laboratory uses various molecular, genetic and electrophysiological techniques to study the <ins class="diffchange diffchange-inline">function </ins>of potassium channels in the nervous system with particular emphasis on the inwardly rectifying (Kir) channels. Molecular techniques are used to study the cellular and subcellular distribution of Kir channels and their functional and biophysical properties on expression in heterologous systems such as Xenopus oocytes or mammalian cell lines. In addition, the laboratory has generated mice carrying targeted deletions of specific Kir channel genes to determine their function "in vivo". Among these, the Kir4.1 channel "knock out" mice display motor, sensory deficits and shorter life span. We are currently investigating the role of Kir4.1 channels in regulation of extracellular potassium in retina and other tissues.  </div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Another major effort in our laboratory is to study the form and function of intrinsically photosensitive ganglion cells in the mammalian retina. Within the retina of the vertebrate eye there are photoreceptors that capture light to regulate non-image forming visual processes such as day–night rhythms and the narrowing and widening of the pupil. To capture light, these special cells called intrinsically photoreceptive retinal ganglion cells, require pigments called melanopsins, similar to the opsins that the rod and cone cells use for turning light into vision. While the development of cones and rods has been extensively studied, much less is known about the development of melanopsin-expressing ganglion cells.  Our lab aims to determine how melanopsin-expressing ganglion cells develop from newborn to adult mouse stages.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Another major effort in our laboratory is to study the form and function of intrinsically photosensitive ganglion cells in the mammalian retina. Within the retina of the vertebrate eye there are photoreceptors that capture light to regulate non-image forming visual processes such as day–night rhythms and the narrowing and widening of the pupil. To capture light, these special cells called intrinsically photoreceptive retinal ganglion cells, require pigments called melanopsins, similar to the opsins that the rod and cone cells use for turning light into vision. While the development of cones and rods has been extensively studied, much less is known about the development of melanopsin-expressing ganglion cells.  Our lab aims to determine how melanopsin-expressing ganglion cells develop from newborn to adult mouse stages.</div></td></tr>  </table>

Paulo Kofuji http://www.openwetware.org/index.php?title=Kofuji_Lab&diff=390846&oldid=prev Paulo Kofuji at 19:26, 12 February 2010 2010-02-12T19:26:51Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 19:26, 12 February 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">[[Image:banner2-kofuji.png]]</del></div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Kofuji}}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Kofuji}}</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>  </table>

Paulo Kofuji http://www.openwetware.org/index.php?title=Kofuji_Lab&diff=390844&oldid=prev Paulo Kofuji at 19:26, 12 February 2010 2010-02-12T19:26:35Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 19:26, 12 February 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Image:banner2-kofuji.png]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Image:banner2-kofuji.png]]</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">{{Kofuji}}</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Kofuji Lab Static webpage [http://www2.neuroscience.umn.edu/paulowebsite/]'''</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Kofuji Lab Static webpage [http://www2.neuroscience.umn.edu/paulowebsite/]'''</div></td></tr>  </table>

Paulo Kofuji http://www.openwetware.org/index.php?title=Kofuji_Lab&diff=390835&oldid=prev Paulo Kofuji at 19:13, 12 February 2010 2010-02-12T19:13:44Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 19:13, 12 February 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline">{{Kofuji}}</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">[[Image:banner2-kofuji.png]]</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Kofuji Lab Static webpage [http://www2.neuroscience.umn.edu/paulowebsite/]'''</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Kofuji Lab Static webpage [http://www2.neuroscience.umn.edu/paulowebsite/]'''</div></td></tr>  </table>

Paulo Kofuji http://www.openwetware.org/index.php?title=Kofuji_Lab&diff=390800&oldid=prev Paulo Kofuji at 17:05, 12 February 2010 2010-02-12T17:05:53Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 17:05, 12 February 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Kofuji}}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Kofuji}}</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''Static webpage [http://www2.neuroscience.umn.edu/paulowebsite/]'''</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>'''<ins class="diffchange diffchange-inline">Kofuji Lab </ins>Static webpage [http://www2.neuroscience.umn.edu/paulowebsite/]'''</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>  </table>

Paulo Kofuji http://www.openwetware.org/index.php?title=Kofuji_Lab&diff=390799&oldid=prev Paulo Kofuji at 17:05, 12 February 2010 2010-02-12T17:05:27Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 17:05, 12 February 2010</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Kofuji}}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Kofuji}}</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">'''Static webpage [http://www2.neuroscience.umn.edu/paulowebsite/]'''</ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Research in our laboratory uses various molecular, genetic and electrophysiological techniques to study the functional roles of potassium channels in the nervous system with particular emphasis on the inwardly rectifying (Kir) channels. Molecular techniques are used to study the cellular and subcellular distribution of Kir channels and their functional and biophysical properties on expression in heterologous systems such as Xenopus oocytes or mammalian cell lines. In addition, the laboratory has generated mice carrying targeted deletions of specific Kir channel genes to determine their function "in vivo". Among these, the Kir4.1 channel "knock out" mice display motor, sensory deficits and shorter life span. We are currently investigating the role of Kir4.1 channels in regulation of extracellular potassium in retina and other tissues.  </div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Research in our laboratory uses various molecular, genetic and electrophysiological techniques to study the functional roles of potassium channels in the nervous system with particular emphasis on the inwardly rectifying (Kir) channels. Molecular techniques are used to study the cellular and subcellular distribution of Kir channels and their functional and biophysical properties on expression in heterologous systems such as Xenopus oocytes or mammalian cell lines. In addition, the laboratory has generated mice carrying targeted deletions of specific Kir channel genes to determine their function "in vivo". Among these, the Kir4.1 channel "knock out" mice display motor, sensory deficits and shorter life span. We are currently investigating the role of Kir4.1 channels in regulation of extracellular potassium in retina and other tissues.  </div></td></tr>  </table>

Paulo Kofuji