Kreeger:Research

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The Kreeger lab utilizes experimental and computational techniques to examine how the endocrine system impacts diseases relevant to women's health:  breast/ovarian cancer, endometriosis, and the impact of estrogens on other normal and disease statesThe lab focuses on how cues such as estrogen impact the cellular signaling networks that regulate cell behavior. Understanding these cellular networks may lead to potential drug targets and rational development of combination therapies. Current projects include addressing the impact of estrogen in a co-culture model of endometriosis and examining a panel of natural and synthetic compounds that initiate estrogen signaling.
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Ovarian cancer is the 5th leading cause of cancer death in women. The high mortality rate is primarily due to the late stage at which ovarian cancer is typically found.  Patients accumulate different mutations in their tumors during disease progression, making it impossible to define a blanket treatment for everyoneWe are working to characterize a panel of ovarian cancer cell lines to capture this diversity and determine how cells respond to current drugs. By delineating molecular signatures that correspond to drug sensitivities we hope to better match patients to drugs and improve prognosis.

Revision as of 12:43, 9 April 2009

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Ovarian cancer is the 5th leading cause of cancer death in women. The high mortality rate is primarily due to the late stage at which ovarian cancer is typically found. Patients accumulate different mutations in their tumors during disease progression, making it impossible to define a blanket treatment for everyone. We are working to characterize a panel of ovarian cancer cell lines to capture this diversity and determine how cells respond to current drugs. By delineating molecular signatures that correspond to drug sensitivities we hope to better match patients to drugs and improve prognosis.
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