Kreitman

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
(December 2012)
(47 intermediate revisions not shown.)
Line 1: Line 1:
{{Kreitman}}
{{Kreitman}}
 +
__NOTOC__
==Focus==
==Focus==
-
[[Image:someimage|thumb]]
+
[[Image:PC_embryo.png|thumb|Expression of early segmentation genes ''eve'' and ''gt'' in a ''Drosophila'' embryo]]
The lab pursues four interrelated research themes:
The lab pursues four interrelated research themes:
-
Molecular population genetics and evolution (Drosophila and Arabidopsis)
+
#Molecular population genetics and evolution (''Drosophila'' and ''Arabidopsis'')
-
Functional evolution of cis-regulatory sequences (Drosophila)
+
#Functional evolution of cis-regulatory sequences (''Drosophila'')
-
Canalization in development and evolution (Drosophila)
+
#Canalization in development and evolution (''Drosophila'')
-
Evolutionary dynamics of disease resistance and pathogenicity (Arabidopsis)
+
#Evolutionary dynamics of disease resistance and pathogenicity (''Arabidopsis'')
 +
 
==News==
==News==
 +
===December 2012===
 +
[[Image:P1020523.JPG|left|400px]]
 +
Misha Bin Marty
 +
{{-}}
 +
 +
===October 2012===
 +
Bin has successfully defended his doctoral thesis and in December he will officially graduate! He is going to join Erin O'Shea group in Harvard and HHMI.
 +
 +
Can't believe that it has been a year since our last update. But be assured that we are not idling. Rather, two manuscripts are being cooked and hopefully we'll be able to get them out of the door early in the new year!
 +
 +
===October 2011===
 +
Misha and Manu have joint force (developmental biology + live imaging + quantitative image analysis) to tackle the question "is there a boundary to transcriptional enhancers?" Enhancers were identified as the minimal piece of sequence that can reproduce the endorgenous expression pattern and for historical reasons, their physical boundaries were "defined" by the restriction enzyme cutting site or pcr primer locations, both of which used by researchers to test difference pieces. Later people have found additional transcription factor binding sites outside these "minimal elements". They are not essential for "producing the expression pattern" in a reporter assay, which is qualitative and doesn't examine the fitness results. Do those additional binding sites matter? How? Check out here: [http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002364 PLoS Genetics]
 +
 +
===August 2011===
 +
Congratulations to Cecelia for assuming a faculty position at the Augustana College at Sioux Falls, SD. She has been such a wonderful colleague and a spiritual core of the lab. We'll surely miss her a lot and best wishes for her [http://web.mac.com/ceceliamiles/Site/About_My_Work.html new lab]!
 +
 +
Also leaving the lab are Levi Barse and Desiree Dickerson. Levi has started as a technician in the lab and over the two year period he has contributed significantly to the project of fly models for diabetes. Desiree was an undergraduate research assistant and has done an honor's thesis work in the kreitman lab. Congratulate both for getting to their next position and good luck for their future!
 +
 +
===July 2011===
 +
Cecelia Miles' collaboration with [http://www.cincinnatichildrens.org/svc/find-professional/m/jun-ma.htm Jun Ma]'s group on the scaling of Bicoid gradient in artificially selected lines for egg size has been published in the journal of Development. Check out it here! [http://www.ncbi.nlm.nih.gov/pubmed/21613328 pubmed]
 +
===April 2011===
 +
[[User:Bin He|Bin He]]'s work on the role of positive selection in transcription factor binding sites turnover has been published on PLoS Genetics. Check out here. [http://www.ncbi.nlm.nih.gov/pubmed/21572512 pubmed]
 +
 +
===Jan 2011===
 +
[http://pondside.uchicago.edu/ecol-evol/people/reinitz.html John Reinitz]'s group joined our department from their previous location in Stony Brooks University. We now created a Kreinitz lab, which is officially up and running! The joint force of evolution + mathematical modeling of enhancer function will surely be super cool! Be sure to follow our latest news!
-
===August 2008===
+
===December 2010===
 +
Susan Lott's work on mapping genetic locus underlying pattern formation differences between drosophila species has been published on EVOLUTION. Check out here. [http://www.ncbi.nlm.nih.gov/pubmed/21121913 pubmed]
-
Read our [http://www.nature.com/nbt/journal/v26/n9/abs/nbt.1490.html  Nature Biotechnology article] describing the application of MITOMI to high-throughput drug discovery targeting a Hepatitis C membrane protein.
+
===July 2010===
 +
Cecelia's work on artificial selection on egg size causing detectable differences in expression patterning got accepted and published in EVOLUTION. Check out the story! [http://www.ncbi.nlm.nih.gov/pubmed/21121913 pubmed]
-
===June 2008===
+
===June 2010===
 +
Congratulations to our graduates!
 +
Sarah Carl is headed to Cambridge and Anna McGeachy is headed to Johns Hopkins.
 +
Go Class of 2010!!
 +
Welcome our new students from The College, Reece DeHaan, Desiree Dickerson, and David Gittin!
-
Nano-Tera awarded a NTF grant to the Laboratory of Biological Network Characterization to develop the next generation of microfluidic devices. For more information on the Nano-Tera initiative click [http://www.nano-tera.ch here].
+
==Group Pictures==
 +
=== The Kreinitz lab at large in 2012 spring ===
 +
[[Image:Kreinitz lab 2012 numbered.png|link=people|left|600px|Kreinitz lab 2012 spring]]
 +
Click on image to see names of people
 +
{{-}}
-
===March 2008===
+
=== Kreitman lab as of 2009 summer ===
-
Prof. Maerkl received one of eight SystemsX RTD grants by the Swiss National Science Foundation to conduct research in the field of Systems Biology. The team involves a total of 4 PIs, including Prof. David Shore (U. Geneva), Prof. Michael Unser (EPFL), Prof. Felix Naef (EPFL), and Dr. Jacques Rougemont (EPFL) forming a dynamic team covering fields ranging from yeast molecular biology, image analysis, computational biology, bioinformatics, to microfluidics and synthetic biology. For more information visit the SystemsX website.
+
[[Image:Group_pic_2009.JPG|left|600px]]
 +
Manu, Bin, Anna, Cecelia, Sara, Marty, Jason (from left to right)
 +
{{-}}

Revision as of 14:37, 27 January 2013

Image:Top_banner.tif


     Home        Research        Internal        Lab Members        Publications        Protocol        Contact       

Focus

Expression of early segmentation genes eve and gt in a Drosophila embryo
Expression of early segmentation genes eve and gt in a Drosophila embryo

The lab pursues four interrelated research themes:

  1. Molecular population genetics and evolution (Drosophila and Arabidopsis)
  2. Functional evolution of cis-regulatory sequences (Drosophila)
  3. Canalization in development and evolution (Drosophila)
  4. Evolutionary dynamics of disease resistance and pathogenicity (Arabidopsis)

News

December 2012

Misha Bin Marty

October 2012

Bin has successfully defended his doctoral thesis and in December he will officially graduate! He is going to join Erin O'Shea group in Harvard and HHMI.

Can't believe that it has been a year since our last update. But be assured that we are not idling. Rather, two manuscripts are being cooked and hopefully we'll be able to get them out of the door early in the new year!

October 2011

Misha and Manu have joint force (developmental biology + live imaging + quantitative image analysis) to tackle the question "is there a boundary to transcriptional enhancers?" Enhancers were identified as the minimal piece of sequence that can reproduce the endorgenous expression pattern and for historical reasons, their physical boundaries were "defined" by the restriction enzyme cutting site or pcr primer locations, both of which used by researchers to test difference pieces. Later people have found additional transcription factor binding sites outside these "minimal elements". They are not essential for "producing the expression pattern" in a reporter assay, which is qualitative and doesn't examine the fitness results. Do those additional binding sites matter? How? Check out here: PLoS Genetics

August 2011

Congratulations to Cecelia for assuming a faculty position at the Augustana College at Sioux Falls, SD. She has been such a wonderful colleague and a spiritual core of the lab. We'll surely miss her a lot and best wishes for her new lab!

Also leaving the lab are Levi Barse and Desiree Dickerson. Levi has started as a technician in the lab and over the two year period he has contributed significantly to the project of fly models for diabetes. Desiree was an undergraduate research assistant and has done an honor's thesis work in the kreitman lab. Congratulate both for getting to their next position and good luck for their future!

July 2011

Cecelia Miles' collaboration with Jun Ma's group on the scaling of Bicoid gradient in artificially selected lines for egg size has been published in the journal of Development. Check out it here! pubmed

April 2011

Bin He's work on the role of positive selection in transcription factor binding sites turnover has been published on PLoS Genetics. Check out here. pubmed

Jan 2011

John Reinitz's group joined our department from their previous location in Stony Brooks University. We now created a Kreinitz lab, which is officially up and running! The joint force of evolution + mathematical modeling of enhancer function will surely be super cool! Be sure to follow our latest news!

December 2010

Susan Lott's work on mapping genetic locus underlying pattern formation differences between drosophila species has been published on EVOLUTION. Check out here. pubmed

July 2010

Cecelia's work on artificial selection on egg size causing detectable differences in expression patterning got accepted and published in EVOLUTION. Check out the story! pubmed

June 2010

Congratulations to our graduates! Sarah Carl is headed to Cambridge and Anna McGeachy is headed to Johns Hopkins. Go Class of 2010!! Welcome our new students from The College, Reece DeHaan, Desiree Dickerson, and David Gittin!

Group Pictures

The Kreinitz lab at large in 2012 spring

Kreinitz lab 2012 spring

Click on image to see names of people

Kreitman lab as of 2009 summer

Manu, Bin, Anna, Cecelia, Sara, Marty, Jason (from left to right)

Personal tools