The lab pursues four interrelated research themes:
Misha and Manu have joint force (developmental biology + live imaging + quantitative image analysis) to tackle the question "is there a boundary to transcriptional enhancers?" Enhancers were identified as the minimal piece of sequence that can reproduce the expected expression pattern and for historical reasons, their physical boundaries were "defined" by the restriction enzyme cutting site or pcr primer locations, both of which used by researchers to test difference pieces. Later people have found additional transcription factor binding sites outside these "minimal elements". They are not essential for "producing the expression pattern" in a reporter assay, which is qualitative and doesn't examine the fitness results. Do those additional binding sites matter? How? Check out here: PLoS Genetics
Congratulations to Cecelia for assuming a faculty position at the Augustana College at Sioux Falls, SD. She has been such a wonderful colleague and a spiritual core of the lab. We'll surely miss her a lot and best wishes for her new lab!
Also leaving the lab are Levi Barse and Desiree Dickerson. Levi has started as a technician in the lab and over the two year period he has contributed significantly to the project of fly models for diabetes. Desiree was an undergraduate research assistant and has done an honor's thesis work in the kreitman lab. Congratulate both for getting to their next position and good luck for their future!
Cecelia Miles' collaboration with Jun Ma's group on the scaling of Bicoid gradient in artificially selected lines for egg size has been published in the journal of Development. Check out it here! pubmed
Susan Lott's work on mapping genetic locus underlying pattern formation differences between drosophila species has been published on EVOLUTION. Check out here. pubmed
Cecelia's work on artificial selection on egg size causing detectable differences in expression patterning got accepted and published in EVOLUTION. Check out the story! pubmed
Congratulations to our graduates! Sarah Carl is headed to Cambridge and Anna McGeachy is headed to Johns Hopkins. Go Class of 2010!! Welcome our new students from The College, Reece DeHaan, Desiree Dickerson, and David Gittin!
Kreitman lab as of 2009 summer: Manu, Bin, Anna, Cecelia, Sara, Marty, Jason (from left to right)