Kubke Lab:/Notebook/Cranial nerve development/2014/12/16: Difference between revisions
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|Neurogenin 1 null mutatns ...... Qiufu, David, 2000 ||Afferent innervation of inner ear is required for efferent outgrowth and in their absence some efferents project via facial nerve||interesting to address gene knockout mice and think about their role within this, found it quite complex though and will need to read it again, one thing that I got from it that was potentially relevant was their use of soaked filter tips to dye nerve stubs which could be a potential new method?|| - | |Neurogenin 1 null mutatns ...... Qiufu, David, 2000 ||Afferent innervation of inner ear is required for efferent outgrowth and in their absence some efferents project via facial nerve||interesting to address gene knockout mice and think about their role within this, found it quite complex though and will need to read it again, one thing that I got from it that was potentially relevant was their use of soaked filter tips to dye nerve stubs which could be a potential new method?|| - | ||
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|Pathfinding by cranial nerve VII, CHang, Fan. Nayak 1992 ||Suggests stage 13 is the age for VII efferent devo (like V). Showed R4 ablation lead to variable patterns of growth in R5 rhombomeres but they always exited through a rhombomere with an even number (ie never through r5) also talks about lateral boundary line as a consistent place that efferents turn rostrally when in rhombomeres that don't have exit points||dismisses role of afferent guidance as "this is probably not the case, as we have seen no evidence that sensory axons enter the hindbrain before the motorneurons exit" but would happily dispute or try test this, also the method here was immuno staining of mounted hind brains and could that be a potential way of imaging really delicate stage 13 or younger hind brains without having to dissect individual nerves? || Jacobsen CO, '79 | |Pathfinding by cranial nerve VII, CHang, Fan. Nayak 1992 ||Suggests stage 13 is the age for VII efferent devo (like V). Showed R4 ablation lead to variable patterns of growth in R5 rhombomeres but they always exited through a rhombomere with an even number (ie never through r5) also talks about lateral boundary line as a consistent place that efferents turn rostrally when in rhombomeres that don't have exit points, suggests a permissive field as mechanism for axon lateral movements and then the boundary of that is the point at which they turn rostrally (position denotes turning not direction though)||dismisses role of afferent guidance as "this is probably not the case, as we have seen no evidence that sensory axons enter the hindbrain before the motorneurons exit" but would happily dispute or try test this, also the method here was immuno staining of mounted hind brains and could that be a potential way of imaging really delicate stage 13 or younger hind brains without having to dissect individual nerves? || Jacobsen CO, '79 | ||
==Fabiana== | ==Fabiana== |
Revision as of 19:26, 15 December 2014
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Entry titleGeneralHelenI have been going over literature all day and will summarise my findings here:
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