LabName:Alcazar: Difference between revisions

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'''''Dear visitor,'''''<br>
<br> Welcome to the Molecular Genetics of Plant Stress Tolerance Lab (Ruben Alcazar) ''' at the Department of Biology, Healthcare & Environment of the University of Barcelona. <br><br>
We're a recently created research group that investigates the '''adaptation of plants to local environments'''. We focus on the evolutionary adaptation of plant populations to '''abiotic and biotic stresses''', which are major challenges for plant survival under the current climate change predictions. Derived from our research, we investigate ways for improving stress protection.<br>
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For a more detailed view of our research, please have a look at our [http://alcazar.openwetware.org/Research.html Research Projects] and [http://alcazar.openwetware.org/Publications.html Scientific Publications] sections. You can follow an updated list of our activities and publications in the NEWS section below. For any other enquires, do not hesitate to contact us directly.<br><br>
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Info currently available in the following languages: <br>
[[http://alcazar.openwetware.org EN]] [[http://alcazar_cat.openwetware.org CAT]] [[http://alcazar_es.openwetware.org ES]]
 
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'''1. MOLECULAR EVOLUTION OF DISEASE RESISTANCE IN PLANTS (R.Alcázar)''' <br>
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In our lab, we make use of the extensive natural variation of [https://en.wikipedia.org/wiki/Arabidopsis_thaliana ''Arabidopsis thaliana''] populations to answer key fundamental questions:


'''''Genetics of Plant-Environment Interactions'''''<br><br>
* '''How plants adapt to local environments including the microbiota?'''
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* '''How plants maintain variability of genes involved in pathogen recognition and to which extent this variability is caused by the interaction with pathogens?'''
Dear visitor,<br><br>
* '''How the environment manipulates immune responses? How this affects the above points?'''




'''Our research is inspired in the genetics work pioneered by Maarten Koornneef and co-workers, expanding our research to evolution and ecology.'''- R.A. <br>
To address these and other questions, we (and others) developed a new model for plant immunity studies based on the use of ''Arabidopsis'' immune-related incompatible hybrids. These are hybrids obtained by crosses of natural ''Arabidopsis'' accessions that exhibit constitutive activation of defense, stunted growth and sterility in the absence of pathogen challenge. Often, such phenotypes are temperature-dependent and suppressed at high temperature.
<br> Welcome to the webpage of the '''Alcázar Lab''' at the University of Barcelona.We study the genetic and molecular bases for the '''adaptation of plants to their local environments'''. We focus on the evolutionary adaptation of plant populations to '''abiotic and biotic stresses''', which are major challenges for plant survival. Derived from our basic research, we investigate ways for improving stress protection.<br><br>
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For a more detailed view of our research, please have a look at our [http://alcazar.openwetware.org/Research.html Research Projects] and [http://alcazar.openwetware.org/Publications.html Scientific Publications] sections. You can follow an updated list of our activities and publications in the NEWS section below.<br>


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These genetic interactions might unravel molecular partners required for proper modulation of defense. Some of these cases are background-dependent and therefore, likely difficult to be observed in classical reference accessions.
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'''CURRENT AREAS OF RESEARCH'''
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'''1. Natural variation and evolution of immune resistance genes in plants.''' <br>
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Plant resistance to pathogens is an important field of research with direct applications and we study it from an evolutionary, population genetics and molecular view. We currently study the '''molecular bases and evolution of ''Resistance'' genes''' and other loci that condition immune activation. We do so by studying Arabidopsis natural hybrids that exhibit activation of defense and fitness loss. We explore the mechanisms that have naturally evolved in plant populations to resist against pathogens and how the immune receptor repertoire is selected and diversified. At the direct interface between plants and the environment, we study how temperature modulates some plant immune responses.<br>
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'''2. Natural variation of abiotic stress tolerance and adaptation'''
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We investigate the molecular and genetic mechanisms underlying the naturally occurring '''tolerance to abiotic stresses in plant populations'''. We're currently studying the genetic bases for the naturally occurring variation of '''stress protective metabolites''' that condition resistance in plants.<br>
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[[Image:Announcement_alcazar.jpg |100px]] '''News and Announcements e-Board'''<br>
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03 Dec 2015. We're pleased to welcome Fredrik Dolfors (Uppsala University) as Master student in our lab.
Since some years, we're using the Ler / Kas-2 immune-related hybrid incompatibility as molecular model to answer some of the questions above. The Landsberg (from Gorzów Wielkopolski, Poland)/Kashmir-2 (from Kashmir mountains) incompatibility involves populations in Central Europe and Central Asia which enable to expand our analyses to population scales. We apply population genetics on top of our molecular and biochemical analyses.  


03 Dec 2015. Alcazar Lab will be part of the new Department of Biology, Health and Environment at UB.


02 Oct 2015. We're pleased to welcome Changxin Liu to our lab as PhD student supported
Derived from our research, we attempt to provide new strategies for crop protection at medium to long-term.  
by the China Scholarship Council.


Applications for [http://openwetware.org/wiki/Alcazar:Master Master in Molecular Biotechnology (2015-16)] in our lab are open.
Master developed at the University of Barcelona.


20 Aug 2015. The review by Alcázar et al.(2010)
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[http://link.springer.com/article/10.1007/s00425-010-1130-0 Polyamines: molecules with regulatory functions in plant abiotic stress tolerance] reaches 350 citations.
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'''2. Polyamines and plant stress protection (R. Alcázar and Antonio F. Tiburcio)'''


21 Jul 2015. Ester Murillo defenses her Master on RPP1-SRF3 incompatibility with honors. Congratulations!!
Polyamines are small amines present in living organisms. Polyamines are essential for cell viability and have co-evolved and participate in developmental and stress signalling pathways. We’re interested to know how polyamines exert their functions in plants, with a focus on stress tolerance. For this, we’re applying modern genetics, genomics and evolutionary biology. Our final goal is to provide new strategies for crop protection against different types of stress. Read our latest publication  on this topic [http://onlinelibrary.wiley.com/doi/10.1111/pce.12714/abstract here]. Most cited review (>450 times) [http://link.springer.com/article/10.1007%2Fs00425-010-1130-0?LI=true here]


In PLoS Genetics: [http://openwetware.org/wiki/Alcazar:pressDec2014 '''Exploring the maintenance and diversity of plant immunity genes in nature''']
by Alcázar et al.


[http://www.frontiersin.org/books/Plant_polyamines_in_stress_and_development/340 E-book in Frontiers in Plant Science 2014, by Antonio F. Tiburcio and Rubén Alcázar, Eds.]
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[[Image:Announcement_alcazar.jpg |100px]] '''News and Announcements e-Board'''<br>
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  NEWS
   
   
Editorial article by Ruben Alcazar & A.F. Tiburcio in Frontiers in Plant Science 2014:
[http://journal.frontiersin.org/Journal/10.3389/fpls.2014.00319/full Plant polyamines in stress and development: an emerging area of research in plant sciences] <br>
[http://link.springer.com/article/10.1007/s00425-014-2055-9 '''Review: The Roles of Polyamines during the lifespan of plants:from development to stress''']
Tiburcio AF, Altabella T, Bitrián M and Alcázar R. (2014) Planta 240: 1-18.<br>


''' PRESS RELEASES'''<br>
''' ACADEMIC PRESS RELEASES'''<br>
  [http://www.ub.edu/web/ub/en/menu_eines/noticies/2015/01/020.html? Alcázar Lab work highlighted by the University of Barcelona 20.01.15]<br>
  [http://www.ub.edu/web/ub/en/menu_eines/noticies/2015/01/020.html? Alcázar Lab work highlighted by the University of Barcelona 20.01.15]<br>
  [http://www.ub.edu/noticies/cgi/event.pl?id=62490&noticiaub=FARMACIA Rubén Alcázar research highlighted by the Faculty of Pharmacy at UB, January 2015]<br>
  [http://www.ub.edu/noticies/cgi/event.pl?id=62490&noticiaub=FARMACIA Rubén Alcázar research highlighted by the Faculty of Pharmacy at UB, January 2015]<br>
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Rubén Alcázar is Ramón y Cajal Researcher at the Department of Natural Products, Plant Biology and Soil Science of the [http://www.ub.edu University of Barcelona].<br>
Rubén Alcázar is Ramón y Cajal Researcher at the Department of Biology, Healthcare and Environment of the [http://www.ub.edu University of Barcelona].<br>
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<br>'''Research in Alcázar Lab is supported by:'''
<br>'''Research in Alcázar Lab is supported by:'''
[[Image:Alcazar_funding.png|900px]]


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Revision as of 08:57, 13 April 2017




Dept. Biology, Healthcare & Environment
Section of Plant Physiology
Facultat de Farmàcia, Av. Joan XXIII 27-31
08028 Barcelona, Spain

<html><a href="http://www.revolvermaps.com/?target=enlarge&i=0ewrbw4fec7"><img src="//ra.revolvermaps.com/h/m/a/0/fff600/128/40/0ewrbw4fec7.png" width="156" height="100" alt="Map" style="border:0;"></a>


Dear visitor,

Welcome to the Molecular Genetics of Plant Stress Tolerance Lab (Ruben Alcazar) at the Department of Biology, Healthcare & Environment of the University of Barcelona.

We're a recently created research group that investigates the adaptation of plants to local environments. We focus on the evolutionary adaptation of plant populations to abiotic and biotic stresses, which are major challenges for plant survival under the current climate change predictions. Derived from our research, we investigate ways for improving stress protection.

For a more detailed view of our research, please have a look at our Research Projects and Scientific Publications sections. You can follow an updated list of our activities and publications in the NEWS section below. For any other enquires, do not hesitate to contact us directly.

Info currently available in the following languages:
[EN] [CAT] [ES]










1. MOLECULAR EVOLUTION OF DISEASE RESISTANCE IN PLANTS (R.Alcázar)


In our lab, we make use of the extensive natural variation of Arabidopsis thaliana populations to answer key fundamental questions:

  • How plants adapt to local environments including the microbiota?
  • How plants maintain variability of genes involved in pathogen recognition and to which extent this variability is caused by the interaction with pathogens?
  • How the environment manipulates immune responses? How this affects the above points?


To address these and other questions, we (and others) developed a new model for plant immunity studies based on the use of Arabidopsis immune-related incompatible hybrids. These are hybrids obtained by crosses of natural Arabidopsis accessions that exhibit constitutive activation of defense, stunted growth and sterility in the absence of pathogen challenge. Often, such phenotypes are temperature-dependent and suppressed at high temperature.


These genetic interactions might unravel molecular partners required for proper modulation of defense. Some of these cases are background-dependent and therefore, likely difficult to be observed in classical reference accessions.


Since some years, we're using the Ler / Kas-2 immune-related hybrid incompatibility as molecular model to answer some of the questions above. The Landsberg (from Gorzów Wielkopolski, Poland)/Kashmir-2 (from Kashmir mountains) incompatibility involves populations in Central Europe and Central Asia which enable to expand our analyses to population scales. We apply population genetics on top of our molecular and biochemical analyses.


Derived from our research, we attempt to provide new strategies for crop protection at medium to long-term.




2. Polyamines and plant stress protection (R. Alcázar and Antonio F. Tiburcio)

Polyamines are small amines present in living organisms. Polyamines are essential for cell viability and have co-evolved and participate in developmental and stress signalling pathways. We’re interested to know how polyamines exert their functions in plants, with a focus on stress tolerance. For this, we’re applying modern genetics, genomics and evolutionary biology. Our final goal is to provide new strategies for crop protection against different types of stress. Read our latest publication on this topic here. Most cited review (>450 times) here



News and Announcements e-Board

 NEWS

ACADEMIC PRESS RELEASES

Alcázar Lab work highlighted by the University of Barcelona 20.01.15
Rubén Alcázar research highlighted by the Faculty of Pharmacy at UB, January 2015
Alcázar Lab work highlighted by the Bulletin of the Spanish Society of Plant Physiology, SEFV. January, 2015
PLoS Genet 2014 highlight by Max Planck Institute, Cologne. 11.12.14.
Arabidopsis semidwarfs: the green revolution in nature 02.12.2013. University of Barcelona.
Hybrid plants with over-reactive immune system 17.11.2010. Max Planck Society.



Rubén Alcázar is Ramón y Cajal Researcher at the Department of Biology, Healthcare and Environment of the University of Barcelona.



Research in Alcázar Lab is supported by:


  • 7th Framework Programme. Marie Curie Career Integration Grant (DISEASENVIRON, PCIG10-GA-2011-303568) of the European Union.
  • Ramón y Cajal Program (RYC-2011-07847) of the Ministerio de Ciencia e Innovación (Spain).
  • BFU2013-41337-P grant of the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia (Ministerio de Economía y Competitividad, Spain).