Lauffenburger:Laura Sontag

Lauffenburger Lab

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Laura Sontag (Computational and Systems Biology doctoral student) Advisors: Professors Peter Sorger (Biology/BE, MIT) and Doug Lauffenburger (Biology/BE, MIT), in collaboration with Professor Tyler Jacks (Biology/Center for Cancer Research, MIT) Computational and experimental analysis of mitogenic signaling pathways activated by mutations in the K-ras oncogene. The Ras signaling cascade constitutes a major pathway shown to be deregulated due to activating mutations in 30% of all human tumors. The vast majority of mutations occur in K-ras. We use genetically engineered mice that harbor a conditional, activatable K-ras allele as a model of human cancer. Email: sontag {AT} mit {DOT} edu Laura Sontag's Homepage