Lauffenburger:Laura Sontag
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activated by oncogenic Ras. The Ras signaling cascade | activated by oncogenic Ras. The Ras signaling cascade | ||
constitutes a major pathway shown to be deregulated due to activating | constitutes a major pathway shown to be deregulated due to activating | ||
| - | mutations in 30% of all human tumors. The vast majority of mutations occur in K-ras. We use genetically engineered mice that harbor a conditional, | + | mutations in 30% of all human tumors. The vast majority of mutations occur in the K-ras gene. We use genetically engineered mice that harbor a conditional, |
activatable K-ras allele as a model of human cancer. | activatable K-ras allele as a model of human cancer. | ||
Revision as of 20:14, 5 February 2006
 Laura Sontag (Computational and Systems Biology doctoral student) Advisors: Professors Peter Sorger (Biology/BE, MIT) and Douglas Lauffenburger (BE/ChemE/Biology, MIT), in collaboration with Professor Tyler Jacks (Biology/Center for Cancer Research, MIT)
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