Laura Sontag (CSB doctoral), in collaboration with Prof. Peter Sorger (Biology/BE, MIT) and Prof. Tyler Jacks (Biology/Center for Cancer Research, MIT)
Computational and experimental analysis of mitogenic signaling pathways activated by a mutation in the K-ras oncogene. The Ras signaling cascade constitutes a major pathway shown to be misregulated due to activating mutations in 30% of all human tumors. The vast majority of mutations occur in K-ras. We use genetically engineered mice that harbor a conditional, activatable allele of the K-ras oncogene as a model of human cancer.