Books
1. Linderman, J.J. and D.A. Lauffenburger, Receptor/Ligand Sorting Along the Endocytic Pathway, Lecture Notes in
Biomathematics Series, vol. 78, Springer-Verlag, Heidelberg, 164 pgs. (1989).
2. Lauffenburger, D.A. and J.J. Linderman, Receptors: Models for Binding, Trafficking, and Signalling, Oxford
University Press, 365 pgs. (1993); 2nd printing (1996).
Invited reviews, commentaries, and book chapters
1. Lauffenburger, D.A. and C. DeLisi, "Cell Surface Receptors: Physical Chemistry and Cellular Recognition", Int.
Rev. Cytol. 84, 269-302 (1983).
2. Lauffenburger, D.A., "Measurement of Phenomenological Parameters for Leukocyte Motility and Chemotaxis",
Agents and Actions Supplements 12, 34-53 (1983).
3. Lauffenburger, D.A., "Chemotaxis: Analysis for Quantitative Studies", Biotech. Prog. 1, 151-160 (1985).
4. Zigmond, S.H., R.O. Klausner, R.T. Tranquillo and D.A. Lauffenburger, "Analysis of the Requirements for Time-
Averaging of Receptor Occupancy for Gradient Detection by Leukocytes", in Membrane Receptors and Cellular
Regulation, ed. M. Czech and C. R. Kahn, pp. 347-356 (1985).
5. Lauffenburger, D.A., "Mathematical Analysis of the Macrophage Response to Bacterial Challenge in the Lung", in
Mononuclear Phagocytes: Characteristics, Physiology and Function, ed. R. van Furth, Z. Cohn and S. Gordon,
pp. 351-357 (1986).
6. Zigmond, S.H. and D.A. Lauffenburger, "Assays for Leukocyte Chemotaxis", Annu. Rev. Med. 37: 149-155
(1986).
7. Lauffenburger, D.A., D.A. Hammer, R.T. Tranquillo, H.M. Buettner and E.S. Fisher, "How Immune Cells Find
Their Targets: Quantitative Studies of Cell Adhesion, Migration and Chemotaxis", in Theoretical Immunology,
ed. A. Perelson, part two, pp. 3-18 (1988).
8. Lauffenburger, D.A., "Models for Receptor-Mediated Cell Phenomena: Adhesion and Migration", Annu. Rev.
Biophys. Biophys. Chem. 20: 387-414 (1991).
9. Lauffenburger, D.A., "Bacterial Chemotaxis and Microbial Ecology", Microb. Ecol. 22: 175-185 (1991).
10. Ford, R.M., B. . Phillips, J.A. Quinn, and D.A. Lauffenburger, "Stopped-Flow Chamber and Image Analysis System
for Quantitative Characterization of Bacterial Population Migration", Microb. Ecol. 22: 127-138 (1991).
11. Lauffenburger, D.A., "Molecules, Mechanics, and Migration of Cells", Appl. Mech. Rev., 47: S287-S290 (1994).
12. Linderman, J.J., P.A. Mahama, K.E. Forsten, and D.A. Lauffenburger, "Diffusion and Probability in Receptor
Binding and Signalling", Adv. Chem. Eng. 19: 51-127 (1994).
13. Lauffenburger, D.A., "Cell Engineering", Biomedical Engineering Handbook, J. D. Bronzino, ed., CRC Press, pp.
1536-1544 (1995).
14. Lauffenburger, D.A. and A.F. Horwitz, "Cell Migration: A Physically Integrated Molecular Process", Cell 84: 359-
369 (1996).
15. Lauffenburger, D.A., “Cell Motility: Making Connections Count”, Nature 383: 390-391 (1996).
16. Grodzinsky, A.J., R.D. Kamm, and D.A. Lauffenburger, "Quantitative Aspects of Tissue Engineering: Basic Issues
in Kinetics, Transport, and Mechanics", Textbook in Tissue Engineering, R. Lanza, R. Langer, and W. Chick,
eds., R.G. Landes, pp. 193-207 (1997).
17. Lauffenburger, D.A., E.M. Fallon, and J.M. Haugh, “Scratching the (Cell) Surface: Cytokine Engineering for
Improved Ligand/Receptor Trafficking Dynamics”, Chem. Biol. 5: R257-R263 (1998).
18. Oehrtman, G., L. Walker, B. Will, L. Opresko, H.S. Wiley, and D.A. Lauffenburger, “Methods for Quantitative
Assessment of Autocrine Cell Loops”, in Tissue Engineering Methods and Protocols, J. Morgan and M.
Yarmush, eds., Humana Press, Totowa NJ, pp. 143-154 (1998).
19. Maheshwari, G. and D.A. Lauffenburger, “Deconstructing (and Reconstructing) Cell Migration”, Microscopy Rev.
Tech. 43: 358-368 (1998).
20. Palecek, S.P., E.A. Cox, A. Huttenlocher, D.A. Lauffenburger, and A.F. Horwitz, “Integrin Adhesion in Cell
Migration”, in Adv. Molec. Cell Biol. 28: 367-388 (1999).
21. Lauffenburger, D.A. and D.V. Schaffer, “The Matrix Delivers: Gene Therapy and Tissue Engineering Team Up to
Speed Bone Regeneration”, Nature Med. 5: 733-734 (1999).
22. Asthagiri, A.R. and D.A. Lauffenburger, “Bioengineering Models of Cell Signaling”, Annu. Rev. Biomed. Eng. 2:
31-53 (2000).
23. Schaffer, D.V. and D.A. Lauffenburger, “Targeted Synthetic Gene Delivery Vectors”, Curr. Op. Molec.
Therapeutics 2: 155-161 (2000).
24. Lauffenburger, D.A., “Cell Signaling Pathways as Control Modules: Complexity for Simplicity?”, Proc. Natl. Acad.
Sci. 97: 5031-5033 (2000).
25. Zandstra, P.W., D.A. Lauffenburger, and C.J. Eaves, “A Ligand-Receptor Signaling Threshold [LIST] Model of
Stem Cell Differentiation Control: A Biologically-Conserved Mechanism Applicable to Hematopoiesis”, Blood
96: 1215-1222 (2000).
26. Varga, C.M., T.J. Wickham, and D.A. Lauffenburger, “Receptor-Mediated Targeting of Gene Delivery Vectors:
Insights from Molecular Mechanisms for Improved Vehicle Design”, Biotech. Bioeng. 70: 593-605 (2000).
27. Lauffenburger, D.A. and L.G. Griffith, “Who’s Got Pull Around Here? Cell Organization in Development and
Tissue Engineering”, Proc. Natl. Acad. Sci. 98: 4282-4284 (2001).
28. Kassis, J., D.A. Lauffenburger, T. Turner, and A. Wells, “Tumor Invasion as Dysregulated Cell Motility”, Sem.
Cancer Biol. 11: 105-117 (2001).
29. Lauffenburger, D.A. and A. Wells, “Getting a Grip: New Insights for Cell Adhesion and Traction”, Nature Cell
Biol. 3: E110-E112 (2001).
30. Orsello, C.E., D.A. Lauffenburger, and D.A. Hammer, “Molecular Perspectives in Cell Adhesion: A Physical and
Engineering Perspective”, Trends Biotech. 19: 310-316 (2001).
31. Caplan, M.R. and D.A. Lauffenburger, “Nature’s Complex Copolymers: Engineering Design of Oligopeptide
Materials”, Ind. Eng. Chem. Res. 41: 403-412 (2002).
32. Glading, A., D.A. Lauffenburger, and A. Wells, “Cutting to the Chase: Calpain Proteases in Cell Motility”, Trends
Cell Biol. 12: 46-54 (2002).
33. Wells, A., J. Kassis, J. Solava, T. Turner, and D.A. Lauffenburger, “Induced Cell Motility in Tumor Invasion”,
Acta Oncol. 41: 124-130 (2002).
34. Sachs, K., D. Gifford, T. Jaakkola, P. Sorger, and D.A. Lauffenburger, “Bayesian Network Approach to Cell
Signaling Pathway Modeling”, Science STKE, www.stke.org/cgi/content/full/sigtrans; 2002/148/pe38 (2002).
35. Wiley, H.S., S.Y. Shvartsman, and D.A. Lauffenburger, “Computational Modeling of the EGF Receptor System: A
Paradigm for Systems Biology”, Trends Cell Biol. 13: 43-50 (2003).
36. Lauffenburger, D.A. and A. Wells, “Quantitative Parsing of Cell Multi-tasking in Wound Repair and Tissue Morphogenesis”, Biophys. J. 84: 3499-3500 (2003).
37. Ideker, T. and D.A. Lauffenburger, “High- to Low-Level Computational Modeling of Biological Pathways”, Trends
Biotech. 21: 255-262 (2003).
38. Shvartsman, S.Y., H.S. Wiley, and D.A. Lauffenburger, “Random Walks and Feedback Loops in Autocrine EGFR
Signaling”, IEEE Control Systems 24: 53-61 (2004).
39. Rao, B.M., D.A. Lauffenburger, and K.D. Wittrup, “Integrating Cell-Level Kinetic Modeling into the Design of
Engineered Protein Therapeutics”, Nature Biotech 23: 191-194 (2005).
40. Wells, A., A. Huttenlocher, and D.A. Lauffenburger, “Calpain Proteases in Cell Adhesion and Motility”, Intl. Rev.
Cytology 245: 1-16 (2005).
41. Janes, K.A. and D.A. Lauffenburger, “A Biological Approach to Computational Models of Proteomic Networks”, Curr. Op. Chem. Biol. (2005, in press).
42. Ideker, T., R. Winslow, and D.A. Lauffenburger, “Bioengineering and Systems Biology”, Annals Biomed. Eng. (2005, accepted).
Refereed journal articles:
1. Keller, K.H. and D.A. Lauffenburger, "The Effect of Flow Channel Thickness on Surface-Induced Blood
Damage", J. Bioeng. 2, 205-217 (1978).
2. Lauffenburger, D.A. and R. Aris, "Measurement of Leukocyte Motility and Chemotaxis Parameters Using a
Quantitative Analysis of the Under-Agarose Migration Assay", Math Biosci. 44, 121-138 (1979).
1. Lauffenburger, D.A. and K.H. Keller, "Effects of Leukocyte Random Motility and Chemotaxis in Tissue
Inflammatory Response", J. Theor. Biol. 81, 475-503 (1979).
2. Lauffenburger, D.A., "Mathematical Model for Tissue Inflammation Dynamics: Effects of Spatial Distribution,
Cell Motility and Chemotaxis", Lect. Notes Biomath. 38, 397-409 (1980).
3. Lauffenburger, D.A. and S.H. Zigmond, "Chemotactic Factor Concentration Gradients in Chemotaxis Assay
Systems", J. Immunol. Methods 40, 45-60 (1981).
4. Lauffenburger, D.A. and C.R. Kennedy, "Analysis of a Lumped Model for Tissue Inflammation Dynamics", Math.
Biosci. 53, 189-221 (1981).
5. Lauffenburger, D.A., R. Aris and K.H. Keller, "Effects of Random Motility on Growth of Bacterial Populations",
Microb. Ecol. 7, 207-227 (1981).
6. Zigmond, S.H., S.J. Sullivan and D.A. Lauffenburger, "Kinetic Analysis of Chemotactic Peptide Receptor
Modulation", J. Cell Biol. 92, 34-43 (1982).
7. Lauffenburger, D.A., "Influence of External Concentration Fluctuations on Leukocyte Chemotactic Orientation",
Cell Biophys. 4, 177-209 (1982)
8. Lauffenburger, D.A., R. Aris and K.H. Keller, "Effects of Cell Motility and Chemotaxis on Microbial Population
Growth", Biophys. J. 40, 209-219 (1982).
9. Lauffenburger, D.A. and C.R. Kennedy, "Localized Bacterial Infection in a Distributed Model for Tissue
Inflammation", J. Math. Biol. 16, 141-163 (1983).
10. Daukas, G., D.A. Lauffenburger and S.H. Zigmond, "Reversible Pinocytosis in Polymorphonuclear Leukocytes",
J. Cell Biol. 96, 1642-1650 (1983).
11. Lauffenburger, D.A., C.R. Rothman and S.H. Zigmond, "Measurement of Leukocyte Motility and Chemotaxis
Parameters with a Linear Under-Agarose Migration Assay", J. Immunol. 131, 940-947 (1983).
12. Lauffenburger, D.A. and B. Calcagno, "Competition Between Two Microbial Populations in a Non-Mixed
Environment: Effect of Cell Random Motility", Biotech. Bioeng. 25, 2103-2125 (1983).
13. Lauffenburger, D.A., C.R. Kennedy and R. Aris, "Traveling Bands of Chemotactic Bacteria in the Context of
Population Growth", Bull. Math. Biol. 46, 19-40 (1984).
14. Stickle, D.F., D.A. Lauffenburger and S.H. Zigmond, "Measurement of Chemoattractant Concentration Profiles
and Diffusion Coefficient in Agarose", J. Immunol. Meth. 70, 65-74 (1984)
15. Rothman, C.R. and D.A. Lauffenburger, "Analysis of the Linear Under-Agarose Leukocyte Migration Assay",
Ann. Biomed. Eng. 11, 451-477 (1984).
16. Lauffenburger, D.A., M. Grady and K.H. Keller, "An Hypothesis for Approaching Swarms of Myxobacteria", J.
Theor. Biol. 110, 257-274 (1984).
17. Lauffenburger, D.A., "Chemotaxis and Cell Aggregation", Lect. Notes Biomath. 55, 198-213 (1984).
18. Lauffenburger, D.A., "Stability of Colicin Plasmids in Continuous Culture: Mathematical Model and Analysis",
Biotech. Prog. 1, 53-59 (1985).
19. Hertz, C.M., D.J. Graves, D.A. Lauffenburger and F.T. Serota, "Use of Cell Affinity Chromatography for
Separation of Lymphocyte Subpopulations", Biotech. Bioeng. 27, 603-612 (1985).
20. Stickle, D.F., D.A. Lauffenburger and R.P. Daniele, "Measurement of Chemokinesis of Alveolar Macrophages
Using the Linear Under-Agarose Assay", J. Leuk. Biol. 38, 383-401 (1985).
21. Tranquillo, R.T. and D.A. Lauffenburger, "Consequences of Chemosensory Receptor Phenomena for Leukocyte
Orientation Behavior", Cell Biophys. 8, 1-46 (1986).
22. Lauffenburger, D.A., "Model for the Dynamics of Colicin Plasmids in Continuous Culture", Ann. NY Acad. Sci. 469, 97-103 (1986).
23. Rivero, M.A. and D.A. Lauffenburger, "Quantification of Bacterial Chemotaxis by Measurement of Model
Parameters using the Capillary Assay", Biotech. Bioeng. 28, 1178-1190 (1986).
24. Linderman, J.J. and D.A. Lauffenburger, "Analysis of Intracellular Ligand/Receptor Sorting", Biophys. J. 50, 295-
305 (1986).
25. Leonard, E.F., K. Ikebe, D.A. Lauffenburger, and L. Muul, "Extracorporeal Cellular Immunotherapy", Trans. Am.
Soc. Artif. Int. Orgs. 32, 633-638 (1986).
26. Fisher, E.S. and D.A. Lauffenburger, "Mathematical Analysis of Cell-Target Encounter Rates in Two Dimensions:
the Effect of Chemotaxis", Biophys. J. 51, 705-716 (1987).
27. Alt, W. and D.A. Lauffenburger, "Transient Behavior of a Chemotaxis System Modeling Certain Types of Tissue
Inflammation", J. Math. Biol. 24, 691-722 (1987).
28. Tranquillo, R.T. and D.A. Lauffenburger, "Stochastic Model of Chemosensory Cell Movement", J. Math. Biol. 25,
229-262 (1987).
29. Tranquillo, R.T. and D.A. Lauffenburger, "Analysis of Leukocyte Chemosensory Movement", Adv. Biosciences
66, 29-38 (1987).
30. Hammer, D.A. and D.A. Lauffenburger, "A Dynamical Model for Receptor-mediated Cell Adhesion to Surfaces",
Biophys. J. 52, 475-487 (1987).
31. Hammer, D.A., J. . Linderman, D.J. Graves and D.A. Lauffenburger, "Affinity Chromatography for Cell
Separation: Mathematical Model and Experimental Analysis", Biotech. Prog. 3, 189-204 (1987).
32. Lauffenburger, D.A., J. . Linderman and L. Berkowitz, "Analysis of Mammalian Cell Growth Factor Receptor
Dynamics", Ann. NY Acad. Sci. 506, 147-162 (1987).
33. Lauffenburger, D.A., M.A. Rivero, F.X. Kelly, R.M. Ford and J. DiRienzo, "Bacterial Chemotaxis: Cell Flux
Model, Parameter Measurement, Population Dynamics and Genetic Manipulation", Ann. NY Acad. Sci. 506,
281-295 (1987).
34. Lauffenburger, D.A., B.E. Farrell, R.T. Tranquillo, A. Kistler and S.H. Zigmond, "Commentary: Gradient
Perception by Neutrophil Leukocytes, Continued", J. Cell Sci. 88, 415-416 (1987).
35. Tranquillo, R.T., D.A. Lauffenburger and S.H. Zigmond, "A Stochastic Model for Leukocyte Random Motility
and Chemotaxis Based on Receptor Binding Fluctuations", J. Cell. Biol. 106, 303-309 (1988).
36. Staffeld, P.O., J.A. Quinn and D.A. Lauffenburger, "Analysis of Cell Transport Phenomena: Bacterial Chemotaxis
in the Capillary Assay", Chem. Eng. Commun. 58, 339-351 (1988).
37. Fisher, E.S., D.A. Lauffenburger and R.P. Daniele, "Effect of Alveolar Macrophage Chemotaxis on Bacterial
Clearance from the Lung Surface", Am. Rev. Resp. Dis. 137, 1129-1134 (1988).
38. Linderman, J.J. and D.A. Lauffenburger, "Analysis of Intracellular Receptor/Ligand Sorting in Endosomes", J.
Theor. Biol. 132, 203-233 (1988).
39. Kelly, F.X., K.J. Dapsis and D.A. Lauffenburger, "Effects of Bacterial Chemotaxis on Dynamics of Microbial
Competition", Microb. Ecol. 16, 115-131 (1988).
40. Lauffenburger, D.A., R.T. Tranquillo and S.H. Zigmond, "Concentration Gradients of Chemotactic Factor in
Chemotaxis Assays", Meth. Enzymol. 162, 85-101 (1988).
41. Tranquillo, R.T., S.H. Zigmond and D.A. Lauffenburger, "Measurement of the Chemotaxis Coefficient for
Polymorphonuclear Leukocytes in the Under-Agarose Assay", Cell Motility Cytoskel. 11, 1-15 (1988).
42. Rupnick, M.A., C.L., Stokes, S.K. Williams and D.A. Lauffenburger, "Quantitation of Random Motility of Human
Microvessel Endothelial Cells Using a Linear Under-Agarose Assay", Lab Invest. 59, 363-372 (1988).
43. Tranquillo, R.T., B.E. Farrell, E.S. Fisher and D.A. Lauffenburger, "A Stochastic Model for Chemosensory Cell
Movement: Application to Neutrophil and Macrophage Persistence and Orientation", Math. Biosci. 90, 287-
303 (1988).
44. Lauffenburger, D.A., "Bacterial Motility and Chemotaxis Effects on Microbial Population Growth", in Laboratory
Models for Microbial Ecosystems, ed. J.W.T. Wimpenny, CRC Press, vol. II, pp 143-172 (1988).
45. Glasgow, J.E., B.E. Farrell, E.S. Fisher, D.A. Lauffenburger and R. P. Daniele, "The Motile Response of Alveolar
Macrophages: An Experimental Study using Single-Cell and Cell Population Approaches", Am. Rev. Resp.
Dis. 139, 320-329 (1989).
46. Buettner, H.M., D.A. Lauffenburger and S.H. Zigmond, "Cell Transport in the Millipore Filter Assay", AIChE J.
35, 459-465 (1989).
47. Lauffenburger, D.A. and C. Cozens, "Regulation of Mammalian Cell Growth by Autocrine Growth Factors:
Analysis of Consequences for Inoculum Cell Density Effects", Biotech. Bioeng. 33, 1365-1378 (1989).
48. Hammer, D.A. and D.A. Lauffenburger, "A Dynamical Model for Receptor-Mediated Cell Adhesion to Surfaces in
Viscous Shear Flow", Cell Biophys. 14, 139-173 (1989).
49. Lauffenburger, D.A., "A Simple Model for the Effects of Receptor-Mediated Cell/Substratum Adhesion on Cell Migration", Chem. Eng. Sci. 44, 1903-1914 (1989).
50. Mayo, K.H., M. Nunez, C. Burke, C. Starbuck, D.A. Lauffenburger and C.R. Savage, "Epidermal Growth Factor
Receptor Binding is not a Simple One-Step Process", J. Biol. Chem. 264, 17838-17844 (1989).
51. Buettner, H.M., D.A. Lauffenburger and S.H. Zigmond, "Measurement of Leukocyte Motility and Chemotaxis
Parameters with the Millipore Filter Assay", J. Immunol. Meth. 123, 25-37 (1989).
52. Rivero, M.A., R.T. Tranquillo, H.M. Buettner and D.A. Lauffenburger, "Transport Models for Chemotactic Cell
Populations Based on Individual Cell Behavior", Chem. Eng. Sci. 44, 2881-2897 (1989).
53. Wattenbarger, M.R., D.J. Graves and D.A. Lauffenburger, "Specific Adhesion of Glycophorin Liposomes to a
Lectin Surface under Shear Flow", Biophys. J. 57, 765-777 (1990).
54. Fisher, E.S. and D.A. Lauffenburger, "Analysis of the Effects of Immune Cell Motility and Chemotaxis on Target
Elimination Dynamics", Math. Biosci. 98, 73-102 (1990).
55. Charnick, S. and D.A. Lauffenburger, "Mathematical Analysis of Cell-Target Encounter Rates in Three
Dimensions: The Effect of Chemotaxis", Biophys. J. 57, 1009-1023 (1990).
56. Starbuck, C., H.S. Wiley and D.A. Lauffenburger, "Epidermal Growth Factor Binding and Trafficking Dynamics
in Fibroblasts: Relationship to Cell Proliferation", Chem. Eng. Sci. 45, 2367-2373 (1990).
57. Cozens-Roberts, C., J.A. Quinn and D.A. Lauffenburger, "Receptor-Mediated Adhesion Phenomena: Model
Studies with the Radial-Flow Detachment Assay", Biophys. J. 58, 107-125 (1990).
58. Farrell, B.E., R.P. Daniele and D.A. Lauffenburger, "Quantitative Relationships Between Single-Cell and Cell-
Population Model Parameters for Chemosensory Migration Responses of Alveolar Macrophages to C5a", Cell
Motility Cytoskel. 16: 279-293 (1990).
59. Stokes, C.L., P.B. Weisz, S.K. Williams and D.A. Lauffenburger, "Inhibition of Microvascular Endothelial Cell
Migration by ß-Cyclodextrin Tetradecasulfate and Hydrocortisone", Microvasc. Res. 40: 279-284 (1990).
60. Cozens-Roberts, C., D.A. Lauffenburger and J.A. Quinn, "Receptor-Mediated Cell Attachment and Detachment
Kinetics - Part I: Probabilistic Model and Analysis", Biophys. J. 58: 841-856 (1990).
61. Cozens-Roberts, C., J.A. Quinn and D.A. Lauffenburger, "Receptor-Mediated Cell Attachment and Detachment
Kinetics - Part II: Experimental Model Studies with the Radial Flow Detachment Assay", Biophys. J. 58:
857-872 (1990).
62. Stokes, C.L., M.A. Rupnick, S.K. Williams and D.A. Lauffenburger, "Chemotaxis of Human Microvessel
Endothelial Cells in Response to Acidic Fibroblast Growth Factor", Lab. Invest. 63: 657-668 (1990).
63. Stokes, C.L., D.A. Lauffenburger, and S.K. Williams, "Endothelial Cell Chemotaxis in Angiogenesis", Lect. Notes
Biomath. 89: 442-452 (1990).
64. Ford, R.M., B.R. Phillips, J.A. Quinn, and D.A. Lauffenburger, "Measurement of Bacterial Random Motility and
Chemotaxis Coefficients: I. Stopped-Flow Diffusion Chamber Assay", Biotech. Bioeng. 37: 647-660 (1991).
65. Ford, R.M. and D.A. Lauffenburger, "Measurement of Bacterial Random Motility and Chemotaxis Coefficients:
II. Application of Single Cell-Based Mathematical Model", Biotechn. Bioeng. 37: 661-672 (1991).
66. DiMilla, P.A., K. Barbee, and D.A. Lauffenburger, "A Mathematical Model for the Effects of Adhesion and
Mechanics on Cell Migration Speed", Biophys. J. 60: 15-37 (1991).
67. Wiley, H.S., J.J. Herbst, B.J. Walsh, D.A. Lauffenburger, M.G. Rosenfeld, and G.N. Gill, "The Role of Tyrosine
Kinase Activity in Endocytosis, Compartmentation, and Downregulation of the EGF Receptor", J. Biol. Chem.
266: 11083-11094 (1991).
68. Stokes, C.L., S.K. Williams, and D.A. Lauffenburger, "Migration of Individual Microvessel Endothelial Cells:
Stochastic Model and Parameter Measurement", J. Cell Sci. 99: 419-430 (1991).
69. Charnick, S., E.S. Fisher, and D.A. Lauffenburger, "Computer Simulations of the Effect of Chemotaxis on
Cell/Target Encounter in Two Dimensions", Bull. Math. Biol. 53: 591-621 (1991).
70. Ford, R.M. and D.A. Lauffenburger, "Analysis of Chemotactic Bacterial Distributions in Population Migration
Assays Using a Mathematical Model Applicable to Steep or Shallow Gradients", Bull. Math. Biol. 53: 721-749
(1991).
71. Cano, M.L., D.A. Lauffenburger, and S.H. Zigmond, "Kinetic Analysis of F-Acton Depolymerization in
Polymorphonuclear Leukocyte Lysates Indicates that Chemoattractant Stimulation Increases Acton Filament
Number Without Altering the Filament Length Distribution", J. Cell Biol. 115: 677-687 (1991).
72. Stokes, C.L., and D.A. Lauffenburger, "Analysis of the Roles of Microvessel Endothelial Cell Random Motility
and Chemotaxis in Angiogenesis", J. Theor. Biol. 152: 377-403 (1991).
73. Forsten, K.E. and D.A. Lauffenburger, "Autocrine Ligand Binding to Cell Receptors: Mathematical Analysis of
Competition by Solution 'Decoys'", Biophys. J.: 518-529 (1992).
74. Starbuck, C. and D.A. Lauffenburger, "Mathematical Model for the Effects of Epidermal Growth Factor Receptor
Trafficking Dynamics on Fibroblast Proliferation Responses", Biotech. Progress 8: 132-143 (1992).
75. Ford, R.M. and D.A. Lauffenburger, "A Simple Expression for Quantifying Bacterial Chemotaxis Using Capillary Assay Data: Application to the Analysis of Enhanced Chemotactic Responses from Growth-Limited Cultures", Math. Biosci. 109: 127-149 (1992).
76. DiMilla, P.A., J.A. Quinn, S.M. Albelda, and D.A. Lauffenburger, "Measurement of Individual Cell Migration
Parameters for Human Tissue Cells", AIChE J. 38: 1092-1104 (1992).
77. Forsten, K.E., and D.A. Lauffenburger, "Interrupting Autocrine Ligand-Receptor Binding: Comparison Between
Receptor Blockers and Ligand Decoys", Biophys. J. 63: 857-861 (1992).
78. Nunez, M., K.H. Mayo, C. Starbuck, and D.A. Lauffenburger, "pH Sensitivity of Epidermal Growth Factor
Complexes", J. Cell Biochem. 51: 312-321 (1993).
79. Saterbak, A., S.C. Kuo, and D.A. Lauffenburger, "Heterogeneity and Probabilistic Binding Contributions to
Receptor-Mediated Cell Detachment Kinetics", Biophys. J. 65: 243-252 (1993).
80. DiMilla, P.A., J. Stone, S.M. Albelda, J.A. Quinn, and D.A. Lauffenburger, "Maximal Migration of Human
Smooth Muscle Cells on Fibronectin and Collagen Type IV Occurs at an Intermediate Adhesiveness", J. Cell
Biol. 122: 729-737 (1993).
81. Kuo, S.C. and D.A. Lauffenburger, "Relationship Between Receptor/Ligand Binding Affinity and Bond Strength",
Biophys. J. 65: 2191-2200 (1993).
82. Schmidt, C.E., A.F. Horwitz, D.A. Lauffenburger, and M. P. Sheetz, "Integrin/Cytoskeleton Interactions in
Migrating Fibroblasts are Dynamic, Asymmetric, and Regulated", J. Cell Biol. 123: 977-991 (1993).
83. Forsten, K.E. and D.A. Lauffenburger, "Probability of Autocrine Ligand Capture by Cell Surface Receptors:
Implications for Ligand Secretion Measurements", J. Comp. Biol. 1: 15-23 (1994).
84. Herbst, J.J., L.K. Opresko, B.J. Walsh, D.A. Lauffenburger, and H.S. Wiley, "Regulation of Postendocytic
Trafficking of the Epidermal Growth Factor Receptor through Endosomal Retention", J. Biol. Chem., 269:
12865-12873 (1994).
85. French, A.R., G.P. Sudlow, H.S. Wiley, and D.A. Lauffenburger, "Postendocytic Trafficking of Epidermal Growth
Factor-Receptor Complexes is Mediated Through Saturable and Specific Endosomal Interactions," J. Biol.
Chem., 269: 15749-15755 (1994).
86. Schmidt, C.E., T. Chen, and D.A. Lauffenburger, "Simulation and Analysis of Directed Integrin Transport on
Migrating Fibroblasts," Biophys. J., 67: 461-474 (1994).
87. Wu, P., J. Hoying, S.K. Williams, B. Kozikowski, and D.A. Lauffenburger, "Soluble Integrin-Binding Competitor
Either Inhibits or Enhances Endothelial Cell Migration, Predictably from Adhesion Effect", Ann. Biomed.
Eng., 22: 144-152 (1994).
88. Forsten, K.E., and D.A. Lauffenburger, "The Role of Low-Affinity Interleukin-2 Receptors in Autocrine Ligand
Binding", Molec. Immunol., 31: 739-751 (1994).
89. Reddy, C.C., A. Wells, and D.A. Lauffenburger, "Proliferative Response of Fibroblasts Expressing Internalization-
Deficient EGF Receptors is Altered via Differential EGF Depletion Effects," Biotech. Progr., 10: 377-384
(1994).
90. Forsten, K.E., R.E. Kozack, D.A. Lauffenburger, and S. Subramaniam, "Numerical Solution of the Nonlinear
Poisson-Boltzmann Equation for a Membrane-Electrolyte System," J. Phys. Chem. 98: 5580- 5586(1994).
91. Will, B.H., D.A. Lauffenburger, and H.S. Wiley, "Studies on Engineered Autocrine Systems: Requirements for
Ligand Release from Cells Producing an Artificial Growth Factor", Tissue Eng. 1: 81-95 (1995).
92. French, A.R., D. Talaki, S.K. Niyogi, and D.A. Lauffenburger, "Intracellular Trafficking of Epidermal Growth
Family Ligands is Directly Influenced by the pH Sensitivity of the Receptor/Ligand Interaction", J. Biol. Chem.
270: 4334-4340 (1995).
93. Lauffenburger, D.A., K.E. Forsten, B. Will, and H.S. Wiley, "Molecular/Cell Engineering Approach to Autocrine
Ligand Control of Cell Function", Ann. Biomed. Eng. 23: 208-215 (1995).
94. Schmidt, C.E., J. Dai, D.A. Lauffenburger, M.P. Sheetz, and A.F. Horwitz, "Integrin-Cytoskeletal Interactions in
Neuronal Growth Cones", J. Neurosci. 15: 3400-3407 (1995).
95. Schmidt, C.E., T. Chen, and D.A. Lauffenburger, "Modulation of Cell Migration Speed via Genetic Manipulation
of Integrin/Cytoskeleton Linkage", J. Cell. Eng. 1: 3-12 (1995).
96. Robinson, A.S. and D.A. Lauffenburger, "Model for ER Chaperone Dynamics and Secretory Protein Interactions",
AIChE Journal 42: 1443-1453 (1996).
97. Chu, L., H.S. Wiley, and D.A. Lauffenburger, "Endocytic Relay as a Potential Means for Enhancing Ligand
Transport through Cellular Tissue Matrices: Analysis and Possible Implications for Drug Delivery", Tissue
Eng. 2: 17-38 (1996).
98. Reddy, C.C., A. Wells, and D.A. Lauffenburger, "Receptor-Mediated Effects on Ligand Availability Influence
Relative Mitogenic Potencies of EGF and TGFα", J. Cell. Physiol. 166: 512-522 (1996).
99. Lauffenburger, D.A., L. Chu, A. French, G. Oehrtman, C. Reddy, A. Wells, S.K. Niyogi, and H.S. Wiley,
"Engineering Dynamics of Growth Factors and Other Therapeutic Ligands", Biotech. Bioeng. 52: 61-80
October 30, 2005 (1996).
100. Palecek, S., C.E. Schmidt, D.A. Lauffenburger, and A.F. Horwitz, "Integrin Dynamics on the Uropodal Region of
Migrating Fibroblasts", J. Cell Sci. 109: 941-952 (1996).
101. French, A.R. and D.A. Lauffenburger, "Intracellular Receptor/Ligand Sorting: Endosomal Retention Component
Model", Biotech. Bioeng. 51: 281-297 (1996).
102. Saterbak, E.A. and D.A. Lauffenburger, "Adhesion Mediated by Bonds in Series", Biotech. Progr. 12: 682-699
(1996).
103. Reddy, C.C., S.K. Niyogi, A. Wells, H.S. Wiley, and D.A. Lauffenburger, “Engineering Epidermal Growth Factor
for Enhanced Mitogenic Potency”, Nature Biotech. 14: 1696-1699 (1996).
104. Palecek, S., J.C. Loftus, M.H. Ginsberg, D.A. Lauffenburger, and A.F. Horwitz, “Integrin/Ligand Binding
Properties Govern Cell Migration Speed through Cell/Substratum Adhesiveness”, Nature 385: 537-540 (1997).
105. Schaffer, D.V., R.L. Neve, and D.A. Lauffenburger, “Use of the Green Fluorescent Protein as a Quantitative
Reporter of Epidermal Growth Factor Receptor-Mediated Gene Delivery”, Tissue Eng. 3: 53-63 (1997).
106. Haugh, J.M. and D.A. Lauffenburger, “Physical Modulation of Intracellular Signaling Processes by Locational
Regulation”, Biophys. J. 72: 2014-2031 (1997).
107. Kuo, S.C., D.A. Hammer, and D.A. Lauffenburger, “Simulation of Detachment of Specifically-Bound Particles
from Surfaces by Shear Flow”, Biophys. J. 73: 517-531 (1997).
108. French, A.R. and D.A. Lauffenburger, “Design Principles for Controlling Receptor/Ligand Trafficking: Effects of
Cellular and Molecular Properties on Endosomal Sorting Outcomes”, Ann. Biomed. Eng. 25: 690-707 (1997).
109. Ware, M.F., D.A. Tice, S.J. Parsons, and D.A. Lauffenburger, “Overexpression of c-Src in Fibroblasts Enhances
Endocytic Internalization of EGF Receptor”, J. Biol. Chem. 272: 30185-30190 (1997).
110. Huttenlocher, A., S.P. Palecek, Q. Lu, W. Zhang, R.L. Mellgren, D.A. Lauffenburger, M.H. Ginsberg, and A.F.
Horwitz, “Regulation of Cell Migration by the Calcium-Dependent Protease Calpain”, J. Biol. Chem. 272:
32719-32722 (1997).
111. Oehrtman, G.T., H.S. Wiley, and D.A. Lauffenburger, “Escape of Autocrine Ligands to Extracellular Medium:
Experimental Test of Theoretical Model Predictions”, Biotech. Bioeng. 57: 571-582 (1998).
112. Leon, E.J., N. Verma, S. Zhang, D.A. Lauffenburger, and R.D. Kamm, “Mechanical Properties of a Class of Self-
Assembling Oliogopeptide Biomaterials”, J. Biomed. Mat. Sci. Polymer Ed. 9: 293-308 (1998).
113. Palecek, S.P., A. Huttenlocher, A.F. Horwitz, and D.A. Lauffenburger, “Physical and Biochemical Regulation of
Integrin Release During Rear Detachment of Migrating Cells”, J. Cell Sci. 111: 929-940 (1998).
114. Ware, M.F., A. Wells, and D.A. Lauffenburger, “EGF Alters Fibroblast Migration Speed and Directional
Persistence Reciprocally and in Matrix-Dependent Manner”, J. Cell Sci. 111: 2423-2432 (1998).
115. Reddy, C.C., A. Wells, and D.A. Lauffenburger, “Comparative Mitogenic Potencies of EGF and TGFα Depend on
Receptor-Limitation versus Ligand-Limitation”, Med. Biol. Eng. Comp. 36: 499-507 (1998).
116. Schaffer, D. and D.A. Lauffenburger, “Optimization of Cell Surface Binding Enhances Efficiency and Specificity
of Molecular Conjugate Gene Delivery”, J. Biol. Chem. 273: 28004-28009 (1998).
117. Wiley, H.S., M. Woolf, L.K. Opresko, P. Burke, B. Will, J. Morgan, and D.A. Lauffenburger, “Removal of the
Membrane-anchoring Domain of EGF Leads to Intracrine Signaling and Disruption of Mammary Epithelial
Cell Organization”, J. Cell Biol. 143: 1317-1328 (1998).
118. Lauffenburger, D.A., G.T. Oehrtman, L. Walker, and H.S. Wiley, “Real-Time Quantitative Measurement of
Autocrine Ligand Binding Indicates that Autocrine Loops Operate over a Short Range”, Proc. Natl. Acad. Sci.
USA: 95: 15368-15373 (1998).
119. Xie, H., M.A. Pallero, K. Gupta, M.F. Ware, P. Chang, D.J. Kwiatkowski, D.A. Lauffenburger, J.E. Murphy-
Ullrich, and A. Wells, “EGF Receptor Regulation of Cell-Substratum Interactions: EGF-Induced Disassembly
of Focal Adhesions does not Require the Motility-Associated PLCγ Signaling Pathway”, J. Cell Sci. 111: 615-
624 (1998).
120. Haugh, J.M. and D.A. Lauffenburger, “Analysis of Receptor Internalization as a Mechanism for Modulating
Signal Transduction Mediated by EGF Receptor”, J. Theor. Biol. 195: 187-218 (1998).
121. Haugh, J.M., K. Schooler, A. Wells, H.S. Wiley, and D.A. Lauffenburger, “Effect of Epidermal Growth Factor
Receptor Internalization on Regulation of the Phospholipase C-γ Signaling Pathway”, J. Biol. Chem. 274:
8958-8965 (1999).
122. Wells, A., M.F. Ware, F.D. Allen, and D.A. Lauffenburger, “Shaping Up for Shipping Out: PLCγ Signaling of
Morphology Changes in EGF-Stimulated Fibroblast Migration”, Cell Mot. Cytoskel. 44: 227-233 (1999).
123. Palecek, S.P., A.F. Horwitz, and D.A. Lauffenburger, “A Kinetic Model for Integrin-Mediated Adhesion Release
during Cell Migration”, Annals Biomed. Eng. 27: 219-235 (1999).
124. Asthagiri, A., A.F. Horwitz, and D.A. Lauffenburger, “A Rapid and Sensitive Quantitative Kinase Activity Assay
Using a Convenient 96-well Format”, Analyt. Biochem. 269: 342-347 (1999).
125. Maheshwari, G., A. Wells, L.G. Griffith, and D.A. Lauffenburger, “Biophysical Integration of Effects of
Epidermal Growth Factor and Fibronectin on Fibroblast Migration”, Biophys. J. 76: 2814-2823 (1999).
126. Dong, J., L.K. Opresko, P.J. Dempsey, D.A. Lauffenburger, R.J. Coffey, H.S. Wiley, “Metalloprotease-Mediated
Ligand Release Regulates Autocrine Signaling through the EGF receptor”, Proc. Natl. Acad. Sci. USA 96:
6235-6240 (1999).
127. Zhang, S., L. Yan, M. Altma, M. Lassle, H. Nugent, F. Frankel, D.A. Lauffenburger, G.M. Whitesides, and A.
Rich, “Biological Surface Engineering: A Simple System for Cell Pattern Formation”, Biomaterials 20: 1213-
1220 (1999).
128. Orsello, C.E., Lauffenburger, D.A., and C.K. Colton, “Characterization of Cell Detachment from Hollow Fiber
Affinity Membranes”, Biomed. Sci. Instr. 35: 315-320 (1999).
129. Asthagiri, A., C. Nelson, A.F. Horwitz, and D.A. Lauffenburger, “Quantitative Relation Between Integrin-Ligand
Binding, Adhesion, and Signaling via Focal Adhesion Kinase and Extracellular-Signal Regulated Kinase 2”, J.
Biol. Chem. 274: 27119-27127 (1999).
130. Haugh, J.M., A.C. Huang, H.S. Wiley, A. Wells, and D.A. Lauffenburger, “Internalized Epidermal Growth
Factor Receptors Participate in the Activation of p21ras in Fibroblasts”, J. Biol. Chem. 274: 34350-34360
(1999).
131. Glading, A., P. Chang, D.A. Lauffenburger, and A. Wells, “EGF Receptor Activation of Calpain is Required
for Fibroblast Motility and Occurs via an ERK/MAPK Signaling Pathway”, J. Biol. Chem. 275: 2390-
2398 (2000).
132. Schaffer, D.V., N. Fidelman, N. Dan, and D.A. Lauffenburger, “Vector Unpackaging is a Limiting Barrier to
Molecular Conjugate Gene Delivery and Expression”, Biotech. Bioeng. 67: 598-606 (2000).
133. Fallon, E.M., S.F. Liparoto, K.J. Lee, T.L. Ciardelli, and D.A. Lauffenburger, “Increased Endosomal Sorting
of Ligand to Recycling Enhances Potency of an Interleukin-2 Analog”, J. Biol. Chem. 275: 6790-6797
(2000).
134. Maheshwari, G., G. Brown, D.A. Lauffenburger, A. Wells, and L.G. Griffith, “Cell Adhesion and Motility
Depend on Nanoscale RGD Clustering”, J. Cell. Sci. 113: 1677-1686 (2000).
135. Zandstra, P.W., H.-V. Lee, G. Daley, L.G. Griffith, and D.A. Lauffenburger, “Leukemia Inhibitor Factor
(LIF) Modulates Embryonic Stem Cell Self-Renewal and Differentiation Independently of Proliferation”,
Biotech. Bioeng. 69: 607-617 (2000).
136. Haugh, J.M., A. Wells, and D.A. Lauffenburger, “Mathematical Modeling of Epidermal Growth Factor
Signaling through the Phospholipase C Pathway: Mechanistic Insights and Predictions for Molecular
Interventions”, Biotech. Bioeng. 70: 225-238 (2000).
137. Fallon, E.M. and D.A. Lauffenburger, “Computational Model for the Effects of Ligand/Receptor Binding
Properties on Interleukin-2 Trafficking Dynamics and T-Cell Proliferation Response”, Biotech. Progr. 16:
905-916 (2000).
138. Asthagiri, A.R., C.A. Reinhart, A.F. Horwitz, and D.A. Lauffenburger, “The Role of Transient ERK2 Signals
in Fibronectin- and Insulin-Mediated DNA Synthesis”, J. Cell Sci. 113: 4499-4510 (2000).
139. Caplan, M.R., P.N. Moore, S. Zhang, R.D. Kamm, D.A. Lauffenburger, "Self-Assembly of a β-sheet Protein
is Governed by Relief of Electrostatic Repulsion Relative to van der Waals Attraction",
Biomacromolecules 1: 627-631 (2000).
140. Asthagiri, A.R. and D.A. Lauffenburger, “A Computational Study of Feedback Effects on Signal Propagation
in a Mitogen-Activated Protein Kinase (MAPK) Pathway Model”, Biotech. Progr. 17: 227-239 (2001).
141. Glading, A., F. Ueberall, S.M. Keyse, D.A. Lauffenburger, and A. Wells, “Membrane-Proximal ERK
Signaling is Required for M-calpain Activation Downstream of EGF Receptor Signaling”, J. Biol. Chem.
276: 23341-23348 (2001).
142. Dewitt, A., J.Y. Dong, H.S. Wiley, and D.A. Lauffenburger, “Quantitative Analysis of the EGF Receptor
Autocrine System Reveals Cryptic Regulation of Cell Response by Ligand Capture”, J. Cell Sci. 114:
2301-2313 (2001).
143. Narang, A., K.K. Subramanian, and D.A. Lauffenburger, “Mathematical Model for Chemoattractant Gradient
Sensing Based on Receptor-Regulated Membrane Phospolipid Signaling Dynamics”, Ann. Biomed. Eng.
29: 677-691 (2001).
144. Shvartsman, S.Y., H.S. Wiley, W.M. Deen, and D.A. Lauffenburger, “Spatial Range of Autocrine Signaling
Loops: Modeling and Computational Analysis”, Biophys. J. 81: 1854-1867 (2001).
145. Hong, K., J. Sherley, and D.A. Lauffenburger, “Methylation of Episomal Plasmids as a Barrier to Transient
Gene Expression via a Synthetic Delivery Vector”, Biomolec. Eng. 18: 185-192 (2001).
146. Varga, C.M., K. Hong, and D.A. Lauffenburger, “Quantitative Analysis of Synthetic Gene Delivery Vector
Design Properties”, Molec. Ther. 4: 438-446 (2001).
147. Maheshwari, G., H.S. Wiley, and D.A. Lauffenburger, “Autocrine Epidermal Growth Factor Stimulates
Directionally-Persistent Mammary Epithelial Cell Migration’, J. Cell Biol. 155: 1123-1128 (2001).
148. Caplan, M.R., E.M. Schwartzfarb, S. Zhang, R.D. Kamm, and D.A. Lauffenburger, “Control of Self-
Assembling Oligopeptide Matrix Formation through Systematic Variation of Amino Acid Sequence”,
Biomaterials 23: 219-227 (2002).
149. Shvartsman, S.V., P. Dent, H.S. Wiley, and D.A. Lauffenburger, “Context-Dependent Signaling in Autocrine
Loops with Positive Feedback: Modeling and Experiments in the EGFR System”, Am. J. Physiol. – Cell
Physiol. 282: C545-C559 (2002).
150. Viswanathan, S., T. Benatar, S. Rose-John, D.A. Lauffenburger, and P.W. Zandstra, “Ligand/Receptor
Signaling Threshold Model Accounts for gp130-Mediated Embryonic Stem Cell Self-Renewal Responses
to LIF and HIL6”, Stem Cells 20: 119-138 (2002).
151. Koo, L.Y., D.J. Irvine, A.M. Mayes, D.A. Lauffenburger, and L.G. Griffith, “Co-Regulation of Cell Adhesion
by Nanoscale RGD Organization and Mechanical Stimulus”, J. Cell Sci. 115: 1423-1433 (2002).
152. Marini, D.M., W. Hwang, D.A. Lauffenburger, S. Zhang, and R.D. Kamm, “Left-handed Helical Ribbon
Intermediates in the Self-Assembly of a β-sheet Peptide”, Nanoletters 2: 295-299 (2002).
153. Allen, F.D., C.F. Asnes, P. Chang, E.L. Elson, D.A. Lauffenburger, and A. Wells, “EGF Induces Acute
Matrix Contraction and Subsequent Calpain-Modulated Relaxation”, Wound Rep. Regen. 10: 67-76
(2002).
154. Shvartsman, S.Y., C.B. Muratov, and D.A. Lauffenburger, “Modeling and Computational Analysis of EGF
Receptor-Mediated Cell Communication in Drosophila Oogenesis”, Development 129: 2577-2589 (2002).
155. Caplan, M.R., E.M. Schwartzfarb, S. Zhang, R.D. Kamm, and D.A. Lauffenburger, “Effects of Systematic
Variation of Amino Acid Sequence on the Mechanical Properties of a Self-Assembling Oligopeptide
Biomaterial”, J. Biomat. Sci. Polymer Ed. 13: 225-236 (2002).
156. Sarkar, C.A., K. Lowenhaupt, T. Horan, T.C. Boone, B. Tidor, and D.A. Lauffenburger, “Rational Cytokine
Design for Increased Lifetime and Enhanced Potency Using pH-Activated ‘Histidine Switching’”, Nature
Biotech. 20: 908-913 (2002).
157. Dewitt, A., T. Iida, H.-Y. Lam, V. Hill, H.S. Wiley, and D.A. Lauffenburger, “Affinity Regulates Spatial
Range of EGF Receptor Autocrine Ligands”, Develop. Biol. 250: 305-316 (2002).
158. Sarkar, C.A. and D.A. Lauffenburger, “Cell-Level Pharmacokinetic Model of GCSF: Implications for Ligand
Lifetime and Potency in Vivo”, Molec. Pharmacol. 63: 147-158 (2003).
159. Hendriks, B., L.K. Opresko, H.S. Wiley, and D.A. Lauffenburger, “Co-Regulation of EGFR/HER2 Levels
and Locations: Quantitative Analysis of HER2 Overexpression Effects”, Cancer Res. 63: 1130-1137
(2003).
160. Ricci, M.S., C.A. Sarkar, E.M. Fallon, D.A. Lauffenburger, and D.N. Brems, “pH Dependence of Structural
Stability of IL-2 and GCSF”, Protein Sci. 12: 1030-1038 (2003).
161. Sarkar, C.A., Lowenhaupt, K., Wang, P.J., Horan, T., and D.A. Lauffenburger, “Parsing the Effects of
Binding, Signaling, and Trafficking on the Mitogenic Potency of GCSF Analogs”, Biotech. Progr. 19:
955-964 (2003).
162. Hendriks, B., L.K. Opresko, H.S. Wiley, and D.A. Lauffenburger, “Quantitative Analysis of HER2-Mediated
Effects on HER2 and EGFR Endocytosis: Distribution of Homo- and Hetero-dimers Depends on Relative
HER2 Levels”, J. Biol. Chem. 278: 23343-23351 (2003).
163. Cheng, C., D.A. Lauffenburger, and T. Morales, “Motile Chondrocytes: Migration Properties and Synthesis
of Collagen II”, Osteoarthr. Cart. 11: 603-612 (2003).
164. Mamoune, A., J.-H. Luo, D.A. Lauffenburger, and A. Wells, “Calpain-2 as a Target for Limiting Prostate
Cancer Invasion”, Cancer Res. 63: 4632-4640 (2003).
165. Janes, K.A., J.G. Albeck, L.X. Peng, P.K. Sorger, D.A. Lauffenburger, and M.B. Yaffe, “High-Throughput
Multiplex Kinase Assay for Monitoring Information Flow in Signaling Networks: Application to Sepsis-
Apoptosis”, Molec. Cell. Proteomics 2: 463-473 (2003).
166. Hendriks, B., H.S. Wiley, and D.A. Lauffenburger, “HER2-Mediated Effects on EGFR Endosomal Sorting:
Analysis of Biophyical Mechanisms”, Biophys. J. 85: 2732-2745 (2003).
167. Viswanathan, S., T. Benatar, M. Mileikovsky, D.A. Lauffenburger, A. Nagy, and P.W. Zandstra,
“Supplementation-Dependent Differences in the Rates of Embryonic Stem Cell Self-Renewal,
Differentiation, and Apoptosis”, Biotech. Bioeng. 84: 505-517 (2003).
168. Rao, B.J., A.T. Girvin, T. Ciardelli, D.A. Lauffenburger, and K.D. Wittrup, “Interleukin-2 Mutants with
Enhanced α-Receptor Subunit Binding Affinity”, Protein Eng. 16: 1081-10877 (2003).
169. Maly, I., H.S. Wiley, and D.A. Lauffenburger, “Self-Organization of Polarized Cell Signaling via Autocrine
EGFR Circuits: Computational Model Analysis”, Biophys. J. 86: 10-22 (2004).
170. Prudhomme, W., K. Duggar, G.Q. Daly, P.W. Zandstra, and D.A. Lauffenburger, “Multi-Variate Proteomic
Analysis of Murine Embryonic Stem Cell Self-Renewal vs Differentiation Behavior”, Proc. Natl. Acad.
Sci. USA 101: 2900-2905 (2004).
171. Iwabu, A., K. Smith, F.D. Allen, D.A. Lauffenburger, and A. Wells, “EGF Induces Fibroblast Contractility
and Motility via a PKCδ-Dependent Pathway”, J. Biol. Chem. 279: 14551-14560 (2004).
172. Tschumperlin, D.J., G. Dai, I.V. Maly, L.H. Laiho, A.K. McVittie, P.T. So, D.A. Lauffenburger, R.D.
Kamm, and J.M. Drazen, “Mechanotransduction via Growth Factor Shedding into a Compliant
Extracellular Space”, Nature 429: 83-86 (2004).
173. Janes, K.A., J. R. Kelly, S. Gaudet, J.G.Albeck, P.K. Sorger, and D.A. Lauffenburger, “Cue-Signal-Response
Analysis of TNF-Induced Apoptosis by Partial Least Squares Regression of Dynamic Multi-Variate
Signaling Network Measurements”, J. Comp. Biol. 11: 544-561 (2004).
174. Lu, H., L.Y. Koo, D.A. Lauffenburger, L.G. Griffith, and K.F. Jensen, “Microfluidic Shear Devices for
Quantitative Analysis of Cell Adhesion”, Analyt. Chem. 76: 5257-5264 (2004).
175. Rao, B.M., I. Driver, D.A. Lauffenburger, and K.D. Wittrup, “IL-2 Variants Engineered for Increased IL-2Ra
Affinity Exhibit Increased Potency Arising from a Cell Surface Ligand Reservoir Effect”, Molec.
Pharmacol. 66: 864-869 (2004).
176. Maly, I., R.T. Lee, and D.A. Lauffenburger, “A Model for Mechanotransduction in Cardiac Muscle: Effects of
Extracellular Matrix Deformation on Autocrine Signaling”, Ann. Biomed. Eng. 32: 1319-1335 (2004).
177. Prudhomme, W., K.H. Duggar, and D.A. Lauffenburger, “Kinetic Model for Deconvolution of Murine
Embryonic Stem Cell Self-Renewal and Differentiation Responses to Cytokines and Extracellular Matrix”,
Biotech. Bioeng. 88: 264-272 (2004).
178. Lazar, C.S., C.M. Cresson, D.A. Lauffenburger, and G.N. Gill, “The Na+/H+ Exchanger Regulatory Factor
Stabilizes EGFR at the Cell Surface”, Molec. Biol. Cell 15: 5470-5480 (2004).
179. Said, M.R., T.J. Begley, A.V. Oppenheim, D.A. Lauffenburger, and L.D. Samson, “Global Network Analysis
of Phenotypic Effects: Protein Networks and Toxicity Modulation in S. cerevisiae”, Proc. Natl. Acad.
Sci. USA 101: 18006-18011 (2004).
180. Hendriks, B.S., G. Orr, A. Wells, H.S. Wiley, and D.A. Lauffenburger, “Parsing ERK Activation Reveals
Quantitatively Equivalent Contributions from EGFR and HER2 in Human Mammary Epithelial Cells”, J.
Biol. Chem. 280: 6157-6169 (2005).
181. Harms, B.D, G.M. Bassi, A.R. Horwitz, and D.A. Lauffenburger, “Directional Persistence of EGF-induced
Cell Migration is Associated with Stabilization of Lamellipodal Protrusions”, Biophys. J. 88: 1479-1488
(2005).
182. Woolf, P.J., W. Prudhomme, L. Daheron, G.Q. Daley, and D.A. Lauffenburger, “Bayesian Analysis of
Signaling Networks Governing Embryonic Stem Cell Fate Decisions”, Bioinformatics 21: 741-753
(2005).
183. Shults, M.D., K.A. Janes, D.A. Lauffenburger, and B. Imperiali, “A Multiplexed Fluorescence-Based Assay
for Protein Kinase Activity in Cell Lysates”, Nature Methods 2: 277-284 (2005).
184. Monine, M.I., A.M. Berezhkovskii, E.J. Joslin, H.S. Wiley, D.A. Lauffenburger, and S.Y. Shvartsman,
“Ligand Accumulation in Autocrine Cell Cultures”, Biophys. J. 88: 2384-2390 (2005).
185. Sachs, K., O. Perez, D. Pe’er, D.A. Lauffenburger, and G.P. Nolan, “Causal Protein Signaling Networks
Derived From Multiparameter Single-Cell Data”, Science 308: 523-529 (2005).
186. Hautaniemi, S., S. Kharait, A. Iwabu, A. Wells, and D.A. Lauffenburger, “Modeling of Signal-Response
Cascades using Decision Tree Analysis”, Bioinformatics 21: 2027-2035 (2005).
187. Dong, J., L.K. Opresko, W. Chrisler, G. Orr, R.D. Quesenberry, D.A. Lauffenburger, and H.S. Wiley, “The
Membrane-Anchoring Domain of EGF Receptor Ligands Dictates Their Ability to Operate in Juxtacrine
Mode”, Molec. Biol. Cell 16: 2984-2998 (2005).
188. Varga, C.M. N.C. Tedford, M. Thomas, A.M. Klibanov, L.G. Griffith, and D.A. Lauffenburger, “Quantitative
Comparison of Polyethylenimine Formulations and Adenoviral Vectors in terms of Intracellular Gene
Delivery Processes”, Gene Therapy 12: 1023-1032 (2005).
189. Hua, F., M.G. Cornejo, M.H. Cardone, C.L. Stokes, and D.A. Lauffenburger, “Effects of Bcl-2 Levels on Fas
Signaling-Induced Caspase-3 Activation: Molecular Genetic Tests of Computational Model Predictions”,
J. Immunol. 175: 985-995 (2005).
190. Yoshioka, J., R.N. Prince, H. Huang, S.B. Perkins, F.U. Cruz, C. MacGillivray, D.A. Lauffenburger, and R.T.
Lee, “Cardiomyocyte Hypertrophy and Degradation of Connexin-43 through Spatially Restricted
Autocrine/Paracrine HB-EGF”, Proc. Natl. Acad. Sci. USA 102: 10622-10627 (2005).
191. Zaman, M.H., R.D. Kamm, P.T. Matsudaira, and D.A. Lauffenburger, “Computational Model for Cell
Migration in Three-Dimensional Matrices”, Biophys. J. 89: 1389-1397 (2005).
192. Rao, B.M., Driver I., D.A. Lauffenburger, and K.D. Wittrup, “High-Affinity CD25-Binding IL-2 Mutants
Potently Stimulate Persistent T-Cell Growth”, Biochem. 44: 10696-10701 (2005).
193. Zhang, Y., A. Wolf-Yadlin, D.J. Pappin, J. Rush, D.A. Lauffenburger, and F.M. White, “Time-Resolved Mass
Spectrometry of Tyrosine Phosphorylation Sites in the EGF Receptor Signaling Network Reveals
Dynamic Modules”, Molec. Cell. Proteomics 4: 1240-1250 (2005).
194. Gaudet, S., K.A. Janes, J.G. Albeck, E.A. Pace, D.A. Lauffenburger, and P.K. Sorger, “A Compendium of
Signals and Responses Triggered by Prodeath and Prosurvival Cytokines”, Molec. Cell. Proteomics 4:
1569-1590 (2005).
195. Viswanathan, S., D. Cheng, R.C. Raghu, D.A. Lauffenburger, and P.W. Zandstra, “Clonal Evolution of Stem
and Differentiated Cells can be Predicted by Integrating Cell-Instrinsic and Extrinsic Parameters”,
Biotech. Appl. Biochem. 42: 119-131 (2005).
196. Kamei, D.T., B.J. Lao, M.S. Ricci, R. Deshpande, H. Xu, B. Tidor, and D.A. Lauffenburger, “Quantitative
Methods for Developing Fc Mutants with Extended Half-Lives”, Biotech. Bioeng. (2005, in press).
197. Janes, K.A., J.G. Albeck, S. Gaudet, P.K. Sorger, D.A. Lauffenburger, and M.B. Yaffe, “A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis”, Science 310: 1646-1653 (2005).
198. Semino, C.E., R.D. Kamm, and D.A. Lauffenburger, “Autocrine EGF Receptor Activation Mediates Endothelial Cell Migration and Vascular Morphogenesis Induced by VEGF Under Interstitial Flow”, Exptl. Cell Res. (2005, in press).
199. Hendriks, B.S., J. Cook, J.M. Burke, J.M. Beusmans, D.A. Lauffenburger, and D. deGraaf, “Computational Modeling of ErbB Family Phosphorylation Dynamics in Response to TGFα and Heregulin Indicates Spatial Compartmentation of Phosphatase Activity”, IEE Systems Biol. (2005, accepted).
Other articles
1. Lauffenburger, D.A., "Effects of Cell Motility Properties on Cell Populations in Ecosystems", ACS Symp. Series
207, 265-292 (1983).
2. Lauffenburger, D.A. and W. Alt, "Singular Perturbation Analysis of a Spatially-Distributed Model for the
Inflammatory Response", AIChE Symp. Series 227, Vol. 79, 50-55 (1983).
3. Lauffenburger, D.A., J.J. Linderman and D.A. Hammer, "Mathematical Modeling of Receptor-Mediated
Mammalian Cell Behavior", Biotech. Bioeng. Symp. Proc. 15, 675-688 (1986).
4. Hammer, D.A. and D.A. Lauffenburger, "Effects of Nonspecific Cell/Surface Interactions on Cell Affinity
Chromatographic Separations", Mat. Res. Soc. Symp. Proc. 110: 739-745, eds. J. S. Hanker and B. L.
Giammara (1989).
5. DiMilla, P.A., J.A. Stone, S.M. Albelda, D.A. Lauffenburger, and J.A. Quinn, "Measurement of Cell Adhesion
and Migration on Protein-Coated Surfaces", Mat. Res. Soc. Symp. Proc. 252: 205-212 (1992).
6. Lauffenburger, D.A., Y-H. Khang, G. Sudlow, K.E. Forsten, and H.S. Wiley, "Quantitative Studies of
EGF/EGF-Receptor Phenomena in Cell Proliferation", in Harnessing Biotechnology for the 21st Century, M.
Ladisch and A. Bose, eds., ACS, pp. 341-344 (1992).
7. Lauffenburger, D.A., C. Starbuck, and H.S. Wiley, "Engineering Growth Factor/Receptor Processes: Effects of
EGF Receptor Trafficking Dynamics on Cell Proliferation Responses to EGF", Proc. US/Japan Conference on
Biotechnology, R. D. Tanner ed., Springer-Verlag, pp. 255-270 (1993).
8. Lauffenburger, D.A., “Engineering Cell Functions”, The NAE Bridge 27: 9-13 (1997).
Book reviews
1. Bacterial Chemotaxis as a Model Behavioral System (D.E. Koshland, Jr.) Math Biosci. 68, 151-153 (1984).
2. Cell Surface Dynamics (A. Perelson, C. DeLisi, and F. Wiegel, eds.), Math. Biosci. 76, 245-247 (1985).
3. Principles of Applied Mathematics (J.P. Keener), Bull. Math. Biol. 52, 319-321 (1990).
4. Physical Forces and the Mammalian Cell (J. Frangos, ed.) AIChE J. 40, 738-739 (1994).
5. Computational Cell Biology (C.P. Fall, E.S. Marland, J.M. Wagner, and J.J. Tyson, eds.) Cell 113: 7-8 (2003).
Patents
1. Granulocyte-Colony Stimulatory Factor Analog Composition and Methods (w/ C.A. Sarkar, B. Tidor, T. Horan &
T. Boone); USA Patents #6946548 and #6790628 (2005).
2. Mutant Interleukin-2 Polypeptides; w/ K.D. Wittrup & B. Rao (application filed July 2003)
