Lauffenburger Lab

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&bull; [[Lauffenburger:Cell Substratum Adhesion, Signaling, and Migration|Cell Substratum Adhesion, Signaling, and Migration]]<br>  
&bull; [[Lauffenburger:Cell Substratum Adhesion, Signaling, and Migration|Cell Substratum Adhesion, Signaling, and Migration]]<br>  
&bull; [[Lauffenburger:Design of Biomolecular Therepeutics|Design of Biomolecular Therepeutics]] <br>
&bull; [[Lauffenburger:Design of Biomolecular Therepeutics|Design of Biomolecular Therepeutics]] <br>
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&bull; [[Lauffenburger:Lab Policies|Lab Policies]]<br>  
&bull; [[Lauffenburger:Lab Policies|Lab Policies]]<br>  
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<h3>Links</h3>
<h3>Links</h3>
&bull; [[Lauffenburger:Tools|Tools]]<br>
&bull; [[Lauffenburger:Tools|Tools]]<br>
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&bull; [http://web.mit.edu/dallab/index.html DL Lab Homepage]<br>
 
&bull; [http://web.mit.edu/dallab/index.html DL Lab Homepage]<br>  
&bull; [http://web.mit.edu/dallab/index.html DL Lab Homepage]<br>  
&bull; [http://web.mit.edu/cheme/index.html MIT Chemical Engineering]<br>  
&bull; [http://web.mit.edu/cheme/index.html MIT Chemical Engineering]<br>  
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&bull; [http://web.mit.edu/be Biological Engineering Division]<br>
&bull; [http://web.mit.edu/be Biological Engineering Division]<br>
&bull; [http://web.mit.edu/bpec/ Biotechnology Process Engineering Center]<br>
&bull; [http://web.mit.edu/bpec/ Biotechnology Process Engineering Center]<br>
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&bull; [http://mit.edu/biology/www/ Department of Biology]
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&bull; [http://mit.edu/biology/www/ Department of Biology]<br>
&bull; [http://web.mit.edu/ MIT]  
&bull; [http://web.mit.edu/ MIT]  
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Revision as of 15:07, 18 September 2005

Doug Lauffenburger's Research Group

Molecular cell bioengineering is the application of engineering approaches to develop quantitative understanding of cell function in terms of fundamental molecular properties, and to apply this understanding for improved design of molecular- and cell-based technologies. Our research group focuses on elucidating important aspects of receptor-mediated regulation of mammalian blood and tissue cell behavioral functions such as proliferation, adhesion, migration, differentiation, and death. A central paradigm of our work is development and testing of computational models -- based on principles from engineering analysis and synthesis -- for receptor regulation of cell function by exploiting techniques of molecular biology to alter parameters characterizing receptor or ligand properties in well-characterized cell systems. Quantitative experimental assays are used to measure cell functions, receptor/ligand interaction parameters, and signaling network dynamics. Problems are primarily motivated by health care technologies of interest to pharmaceutical and biotechnological companies, and emphasize multi-disciplinary collaborative interactions, including colleagues in both academia and industry.

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