Lee:Literature Proteasomes

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Proteasome Biology general review

  1. Hoeller D, Dikic I. Targeting the ubiquitin system in cancer therapy.Nature. 2009 Mar 26;458(7237):438-44. (pmid=19325623)
  2. Mani A, Gelmann EP. The ubiquitin-proteasome pathway and its role in cancer. J Clin Oncol. 2005 Jul 20;23(21):4776-89. (pmid=16034054)
  3. Murata S, Yashiroda H, Tanaka K. Molecular mechanisms of proteasome assembly. Nat Rev Mol Cell Biol. 2009 Feb;10(2):104-15. (pmid=19165213)


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All Medline abstracts: PubMed HubMed


  1. pmid=9419215
  2. pmid=12456675 (C-terminal Myc and FLAG tags for MECL, LMP2,Delta, Z)
  3. pmid=10329130 (modification of prepeptide sequence)
  4. pmid=10363659
  5. pmid=9321388 (GFP fusion)
  6. pmid=18728217
  7. pmid=19525961

Resistance mechanisms for proteasome inhibitors

  1. Giada Bianchi,Laura Oliva,Paolo Cascio,5 Niccolo Pengo,Francesca Fontana, Fulvia Cerruti, Andrea Orsi,Elena Pasqualetto, Alexandre Mezghrani, Valeria Calbi, Giovanni Palladini, Nicola Giuliani, Kenneth C. Anderson,Roberto Sitia,and Simone Cenci. The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition. Blood. 2009 Mar 26;113(13):3040-9 : 3040-3049.(pmid=19164601)
  2. Lü S, Yang J, Song X, Gong S, Zhou H, Guo L, Song N, Bao X, Chen P, Wang J. Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line. J Pharmacol Exp Ther. 2008 Aug;326(2):423-31. (pmid=18502982)
  3. Fuchs D, Berges C, Opelz G, Daniel V, Naujokat C. Increased expression and altered subunit composition of proteasomes induced by continuous proteasome inhibition establish apoptosis resistance and hyperproliferation of Burkitt lymphoma cells. J Cell Biochem. 2008 Jan 1;103(1):270-83. (pmid=17516511)

Proteasome inhibitors in lung cancer

  1. Davies AM, Chansky K, Lara PN Jr, Gumerlock PH, Crowley J, Albain KS, Vogel SJ, Gandara DR; Southwest Oncology Group. Bortezomib plus gemcitabine/carboplatin as first-line treatment of advanced non-small cell lung cancer: a phase II Southwest Oncology Group Study (S0339). J Thorac Oncol. 2009 Jan;4(1):87-92.
  2. Ling YH, Liebes L, Jiang JD, Holland JF, Elliott PJ, Adams J, Muggia FM, Perez-Soler R. Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines. Clin Cancer Res. 2003 Mar;9(3):1145-54.

Proteasome inhibitors in pancreatic cancer

  1. Alberts SR, Foster NR, Morton RF, Kugler J, Schaefer P, Wiesenfeld M, Fitch TR, Steen P, Kim GP, Gill S. PS-341 and gemcitabine in patients with metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group (NCCTG) randomized phase II study. Ann Oncol. 2005 Oct;16(10):1654-61.
  2. Bold RJ, Virudachalam S, McConkey DJ. Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome. J Surg Res. 2001 Sep;100(1):11-7. (PMID: 11516199)
  3. Guo Q, Chen Y, Wu Y. Enhancing apoptosis and overcoming resistance of gemcitabine in pancreatic cancer with bortezomib: a role of death-associated protein kinase-related apoptosis-inducing protein kinase 1. Tumori. 2009 Nov-Dec;95(6):796-803.
  4. Tang ZY, Wu YL, Gao SL, Shen HW. Effects of the proteasome inhibitor bortezomib on gene expression profiles of pancreatic cancer cells. J Surg Res. 2008 Mar;145(1):111-23.


  1. 1 pmid=16889756
  2. 2 pmid=16724054
  3. 3 pmid=17183360
  4. 4 pmid=16618413

MDR1 & apoptosis, NF-kB

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All Medline abstracts: PubMed HubMed
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