Li Lab:Softwares

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* [http://code.google.com/p/bsmap/ BSMAP: whole genome Bisulfite Sequence MAPping program]
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* [http://code.google.com/p/bsmap/ BSMAP: whole genome Bisulfite Sequence MAPping program]  
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Whole-genome shotgun bisulfite sequencing is a powerful tool to detect DNA methylation at single-base resolution.  Mapping millions of bisulfite reads remains a great challenge due to the increased searching space, reduced complexity of bisulfite sequence, multiple CpG heterogeneous methylation within a single read, etc.  Hereby, we present the first general-purpose Bisulfite Sequence MAPping program, BSMAP. By combining fast seeding and bitwise masking, BSMAP addresses all the above issues and offers superior performance and flexibility.

Revision as of 14:45, 17 November 2008

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  • Whole Genome Phylogeny

Phylogeny Based on Whole Genome as inferred from Complete Information Set Analysis


A Hidden Markov Model for Analyzing ChIP-chip Experiments on Genome Tiling Arrays


A model-based algorithm for finding enriched regions in ChIP-Chip experiments


An integrated webserver for analyzing ChIP-chip data


A intuitive and efficient algorithm for the mapping of millions of query oligonucleotide fragments to the genome of any given length, at least an order of magnitude faster than other popular existing tools


A model-based algorithm for finding enriched regions in ChIP-Seq experiments.


Whole-genome shotgun bisulfite sequencing is a powerful tool to detect DNA methylation at single-base resolution. Mapping millions of bisulfite reads remains a great challenge due to the increased searching space, reduced complexity of bisulfite sequence, multiple CpG heterogeneous methylation within a single read, etc. Hereby, we present the first general-purpose Bisulfite Sequence MAPping program, BSMAP. By combining fast seeding and bitwise masking, BSMAP addresses all the above issues and offers superior performance and flexibility.
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