Lon Chubiz

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==Bio==
==Bio==
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*Fourth year graduate student in [[User:ChrisRao|Chris Rao's]] group in [http://www.scs.uiuc.edu/chem_eng Chemical and Biomolecular Engineering] at the [http://www.uiuc.edu University of Illinois at Urbana-Champaign].  
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*Post-doctoral Fellow in Chris Marx's lab at Harvard University
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*Ph.D. research in [[User:ChrisRao|Chris Rao's]] group in [http://www.scs.uiuc.edu/chem_eng Chemical and Biomolecular Engineering] at the [http://www.uiuc.edu University of Illinois at Urbana-Champaign].  
*Undergraduate degree in [http://www.cems.umn.edu/ Chemical Engineering] from the [http://www.umn.edu University of Minnesota].
*Undergraduate degree in [http://www.cems.umn.edu/ Chemical Engineering] from the [http://www.umn.edu University of Minnesota].
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==Research Interests==
==Research Interests==
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'''Translational regulation and control strategies.''' In all branches of life organisms have evolved highly sophisticated strategies to regulate gene expression. Although transcriptional level control has been extensively studied, translational level events are becoming more important to understand. A primary example is the observation that there is very limited correlation between mRNA abundance and protein concentration. As we try to reprogram cellular behavior with increasingly sensitive systems, this paradox will become an important phenomena to understand in order to produce optimized cellular responses.
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'''Antibiotic resistance.'''
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'''Synthetic ecology.'''
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'''Evolutionary dynamics.'''
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'''Transcriptional Regulatory Networks and Cellular Physiology.''' Cellular processes must be regulated at multiple levels. In addition, they often require coordination between numerous systems. One strategy that has emerged throughout millions of years of evolution is for cells to regulate physiological events at the level of transcription. Many of these networks are known to be highly interconnected, in that regulatory components from one network can influence many networks. Understanding how these interconnected networks result in reliable, reproducible execution of processes is a long term interest of mine.
 +
 
 +
'''Translational regulation and control strategies.''' In all branches of life organisms have evolved highly sophisticated strategies to regulate gene expression. Although transcriptional level control has been extensively studied, translational level events are becoming increasingly important to understand. A primary example is the observation that there is very limited correlation between mRNA abundance and protein concentration. As we try to reprogram cellular behavior with increasingly sensitive systems, this paradox will become an important phenomena to understand in order to produce optimized cellular responses.
 +
 
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==Publications==
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*Chubiz, L.M., Lee, M.C., Delaney, N.F., and Marx, C.J., "FREQ-Seq: A rapid, cost-effective, sequencing-based method to determine allele frequencies directly from mixed populations", <i>PLoS One</i> (2012), Accepted
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*Chubiz, L.M., Glekas, G.D., and Rao, C.V., "Transcriptional cross talk within the mar-sox-rob regulon in <i>Escherichia coli</i> is Limited to the <i>rob</i> and <i>marRAB</i> operons", <i>J. Bacteriol.</i> (2012) PMID: 22753060
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*Chubiz, L.M., and Rao, C.V., "The role of the <i>mar/sox/rob</i> regulon in regulating outer membrane porin expression", <i>J. Bacteriol.</i> (2011) PMID: 21398557
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*Chubiz, L.M., and Rao, C.V., "Aromatic acid metabolites of <i>Escherichia coli</i> K-12 can induce the <i>marRAB</i> operon", <i>J. Bacteriol.</i> (2010) PMID: 20639340
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*Min, T.L., Mears, P.J., Chubiz, L.M., Rao, C.V., Golding, I., Chemla, Y.R., "High-resolution, long-term characterization of bacterial motility using optical tweezers", <i>Nat. Methods</i> (2009) PMID: 19801991
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*Chubiz, L.M. and Rao, C.V., "Computational design of orthogonal ribosomes", <i>Nucleic Acids Res.</i> (2008) PMID: 18522973
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'''Transcriptional Regulatory Networks and Cellular Physiology.'''
 
==Personal Interests==
==Personal Interests==
* Summer: Bicycling, outdoor activities.
* Summer: Bicycling, outdoor activities.
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* Winter: Snowboarding, Bicycling (yes, I actually ride my bike year-round)
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* Winter: Snowboarding, Bicycling
* Indoor: Reading, Movies, and general R&R
* Indoor: Reading, Movies, and general R&R
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==Contact==
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*Post : Harvard University, The Biological Labs 3082, Cambridge, MA 02445
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*Email: lchubiz AT gmail DOT com OR lchubiz AT fas DOT harvard DOT edu

Revision as of 20:13, 9 October 2012

Bio

Graduate Activities

  • Member OWW Steering Committee
  • Internal Vice-President ChBE Graduate Student Advisory Council (2005-2007)
  • Teaching Assisant
    • Mass Transfer and Separations, Spring 2007
    • Process Dynamics and Control, Fall 2006
    • Unit Operations, Spring 2006
    • Fluid Mechanics, Fall 2005

Research Interests

Antibiotic resistance.

Synthetic ecology.

Evolutionary dynamics.


Transcriptional Regulatory Networks and Cellular Physiology. Cellular processes must be regulated at multiple levels. In addition, they often require coordination between numerous systems. One strategy that has emerged throughout millions of years of evolution is for cells to regulate physiological events at the level of transcription. Many of these networks are known to be highly interconnected, in that regulatory components from one network can influence many networks. Understanding how these interconnected networks result in reliable, reproducible execution of processes is a long term interest of mine.

Translational regulation and control strategies. In all branches of life organisms have evolved highly sophisticated strategies to regulate gene expression. Although transcriptional level control has been extensively studied, translational level events are becoming increasingly important to understand. A primary example is the observation that there is very limited correlation between mRNA abundance and protein concentration. As we try to reprogram cellular behavior with increasingly sensitive systems, this paradox will become an important phenomena to understand in order to produce optimized cellular responses.

Publications

  • Chubiz, L.M., Lee, M.C., Delaney, N.F., and Marx, C.J., "FREQ-Seq: A rapid, cost-effective, sequencing-based method to determine allele frequencies directly from mixed populations", PLoS One (2012), Accepted
  • Chubiz, L.M., Glekas, G.D., and Rao, C.V., "Transcriptional cross talk within the mar-sox-rob regulon in Escherichia coli is Limited to the rob and marRAB operons", J. Bacteriol. (2012) PMID: 22753060
  • Chubiz, L.M., and Rao, C.V., "The role of the mar/sox/rob regulon in regulating outer membrane porin expression", J. Bacteriol. (2011) PMID: 21398557
  • Chubiz, L.M., and Rao, C.V., "Aromatic acid metabolites of Escherichia coli K-12 can induce the marRAB operon", J. Bacteriol. (2010) PMID: 20639340
  • Min, T.L., Mears, P.J., Chubiz, L.M., Rao, C.V., Golding, I., Chemla, Y.R., "High-resolution, long-term characterization of bacterial motility using optical tweezers", Nat. Methods (2009) PMID: 19801991
  • Chubiz, L.M. and Rao, C.V., "Computational design of orthogonal ribosomes", Nucleic Acids Res. (2008) PMID: 18522973

Personal Interests

  • Summer: Bicycling, outdoor activities.
  • Winter: Snowboarding, Bicycling
  • Indoor: Reading, Movies, and general R&R

Contact

  • Post : Harvard University, The Biological Labs 3082, Cambridge, MA 02445
  • Email: lchubiz AT gmail DOT com OR lchubiz AT fas DOT harvard DOT edu
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