Mag:Publications

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  • de Magalhães JP, Costa J (2009) A database of vertebrate longevity records and their relation to other life-history traits. Journal of Evolutionary Biology 22:1770-1774. [Webpage]
  • de Magalhães JP, Curado J, Church GM (2009) Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics 25:875-881. [Supplementary material] [Webpage]
  • de Magalhães JP (2009) Aging Research in the Post-Genome Era: New Technologies for an Old Problem. In: Foyer CH, Faragher R, Thornalley PJ (eds.), Redox Metabolism and Longevity Relationships in Animals and Plants. Taylor and Francis, New York, pp. 99-115.
  • de Magalhães JP, Budovsky A, Lehmann G, Costa J, Li Y, Fraifeld V, Church GM (2009) The Human Ageing Genomic Resources: online databases and tools for biogerontologists. Aging Cell 8:65-72. [Webpage]
  • de Magalhães JP, Faragher RGA (2008) Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity. BioEssays 30:567-578.
  • de Magalhães JP, Sedivy JM, Finch CE, Austad SN, Buffenstein R, Church GM (2008) Proposal to Sequence an Organism of Unique Interest for Research on Aging: Heterocephalus glaber, the Naked Mole-Rat. Submitted to the NIH/NHGRI on March 17, 2008. [Webpage]
  • de Magalhães JP, Church GM (2007) Analyses of human-chimpanzee orthologous gene pairs to explore evolutionary hypotheses of aging. Mechanisms of Ageing and Development 128:355-364. [Webpage]
  • de Magalhães JP, Sedivy JM, Finch CE, Austad SN, Church GM (2007) A proposal to sequence genomes of unique interest for research on aging. Journal of Gerontology: Biological Sciences 62:583-584. [Webpage]
  • de Magalhães JP, Costa J, Church GM (2007) An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts. Journal of Gerontology: Biological Sciences 62:149-160.
  • de Magalhães JP, Church GM (2006) Cells discover fire: Employing reactive oxygen species in development and consequences for aging. Experimental Gerontology 41:1-10.
  • de Magalhães JP (2006) Species Selection in Comparative Studies of Aging and Antiaging Research. In: Conn PM (ed.), Handbook of Models for Human Aging. Elsevier Academic Press, Burlington, MA, pp. 9-20.
  • de Magalhães JP (2005) Human disease-associated mitochondrial mutations fixed in nonhuman primates. Journal of Molecular Evolution 61:491-497. [Webpage]
  • de Magalhães JP, Church GM (2005) Genomes optimize reproduction: aging as a consequence of the developmental program. Physiology 20:252-259.
  • de Magalhães JP, Sandberg A (2005) Cognitive aging as an extension of brain development: A model linking learning, brain plasticity, and neurodegeneration. Mechanisms of Ageing and Development 126:1026-1033.
  • de Magalhães JP, Costa J, Toussaint O (2005) HAGR: the Human Ageing Genomic Resources. Nucleic Acids Research 33:D537-D543. [Webpage]
  • de Magalhães JP, Cabral JAS, Magalhães D (2005) The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging. Genetics 169:265-274. [Supplementary material] [Software]
  • de Magalhães JP (2005) Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations. Ageing Research Reviews 4:1-22.
  • de Magalhães JP (2004) From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing. Experimental Cell Research 300:1-10.
  • de Magalhães JP, Chainiaux F, de Longueville F, Mainfroid V, Migeot V, Marcq L, Remacle J, Salmon M, Toussaint O (2004) Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase. Experimental Gerontology 39:1379-1389. [Supplementary material]
  • de Magalhães JP, Toussaint O (2004) Telomeres and telomerase: a modern Fountain of Youth? Rejuvenation Research 7:126-132.
  • de Magalhães JP, Toussaint O (2004) GenAge: a genomic and proteomic network map of human ageing. FEBS Letters 571:243-247.
  • de Magalhães JP, Migeot V, Mainfroid V, de Longueville F, Remacle J, Toussaint O (2004) No increase in senescence-associated beta-galactosidase activity in Werner syndrome fibroblasts after exposure to H2O2. In: de Grey ADNJ (ed.), Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable. Annals of the New York Academy of Sciences, Vol. 1019, pp. 375-378.
  • de Magalhães JP, Toussaint O (2004) How bioinformatics can help reverse engineer human aging. Ageing Research Reviews 3:125-141.
  • de Magalhães JP (2004) The Dream of Elixir Vitae. In: Immortality Institute (ed.), The Scientific Conquest of Death: Essays on Infinite Lifespans. Libros En Red, Buenos Aires, pp. 47-62. [Adapted version]
  • de Magalhães JP (2004) Modelling human ageing: role of telomeres in stress-induced premature senescence and design of anti-ageing strategies. Doctoral thesis, University of Namur, Department of Biology, Namur, Belgium.
  • de Magalhães JP (2003) Winning the war against aging. The Futurist, 37:48-50. [Adapted version]
  • de Magalhães JP (2003) Is mammalian aging genetically controlled? Biogerontology 4:119-120.
  • de Magalhães JP, Chainiaux F, Remacle J, Toussaint O (2002) Stress-induced premature senescence in BJ and hTERT-BJ1 human fibroblasts. FEBS Letters 523:157-162.
  • Chainiaux F, Magalhaes JP, Eliaers F, Remacle J, Toussaint O (2002) UV-B induced premature senescence of human diploid skin fibroblasts. International Journal of Biochemistry & Cell Biology 34:1331-1339.
  • de Magalhães JP, Toussaint O (2002) The evolution of mammalian aging. Experimental Gerontology 37:769-775.
  • Frippiat C, Chen QM, Zdanov S, Magalhaes JP, Remacle J, Toussaint O (2001) Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. Journal of Biological Chemistry 276:2531-2537.


Aging Research

For prospective Students



http://pcwww.liv.ac.uk/~aging/publications.html

2009

de Magalhães JP, Costa J (2009) A database of vertebrate longevity records and their relation to other life-history traits. Journal of Evolutionary Biology 22:1770-1774. [Webpage]

de Magalhães JP, Curado J, Church GM (2009) Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics 25:875-881. [Supplementary material] [Webpage]

de Magalhães JP (2009) Aging Research in the Post-Genome Era: New Technologies for an Old Problem. In: Foyer CH, Faragher R, Thornalley PJ (eds.), Redox Metabolism and Longevity Relationships in Animals and Plants. Taylor and Francis, New York, pp. 99-115.

de Magalhães JP, Budovsky A, Lehmann G, Costa J, Li Y, Fraifeld V, Church GM (2009) The Human Ageing Genomic Resources: online databases and tools for biogerontologists. Aging Cell 8:65-72. [Webpage] 2008

de Magalhães JP, Faragher RGA (2008) Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity. BioEssays 30:567-578.

de Magalhães JP, Sedivy JM, Finch CE, Austad SN, Buffenstein R, Church GM (2008) Proposal to Sequence an Organism of Unique Interest for Research on Aging: Heterocephalus glaber, the Naked Mole-Rat. Submitted to the NIH/NHGRI on March 17, 2008. [Webpage] 2007

de Magalhães JP, Church GM (2007) Analyses of human-chimpanzee orthologous gene pairs to explore evolutionary hypotheses of aging. Mechanisms of Ageing and Development 128:355-364. [Webpage]

de Magalhães JP, Sedivy JM, Finch CE, Austad SN, Church GM (2007) A proposal to sequence genomes of unique interest for research on aging. Journal of Gerontology: Biological Sciences 62:583-584. [Webpage]

de Magalhães JP, Costa J, Church GM (2007) An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts. Journal of Gerontology: Biological Sciences 62:149-160. 2006

de Magalhães JP, Church GM (2006) Cells discover fire: Employing reactive oxygen species in development and consequences for aging. Experimental Gerontology 41:1-10.

de Magalhães JP (2006) Species Selection in Comparative Studies of Aging and Antiaging Research. In: Conn PM (ed.), Handbook of Models for Human Aging. Elsevier Academic Press, Burlington, MA, pp. 9-20. 2005

de Magalhães JP (2005) Human disease-associated mitochondrial mutations fixed in nonhuman primates. Journal of Molecular Evolution 61:491-497. [Webpage]

de Magalhães JP, Church GM (2005) Genomes optimize reproduction: aging as a consequence of the developmental program. Physiology 20:252-259.

de Magalhães JP, Sandberg A (2005) Cognitive aging as an extension of brain development: A model linking learning, brain plasticity, and neurodegeneration. Mechanisms of Ageing and Development 126:1026-1033.

de Magalhães JP, Costa J, Toussaint O (2005) HAGR: the Human Ageing Genomic Resources. Nucleic Acids Research 33:D537-D543. [Webpage]

de Magalhães JP, Cabral JAS, Magalhães D (2005) The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging. Genetics 169:265-274. [Supplementary material] [Software]

de Magalhães JP (2005) Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations. Ageing Research Reviews 4:1-22. 2004

de Magalhães JP (2004) From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing. Experimental Cell Research 300:1-10.

de Magalhães JP, Chainiaux F, de Longueville F, Mainfroid V, Migeot V, Marcq L, Remacle J, Salmon M, Toussaint O (2004) Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase. Experimental Gerontology 39:1379-1389. [Supplementary material]

de Magalhães JP, Toussaint O (2004) Telomeres and telomerase: a modern Fountain of Youth? Rejuvenation Research 7:126-132.

de Magalhães JP, Toussaint O (2004) GenAge: a genomic and proteomic network map of human ageing. FEBS Letters 571:243-247.

de Magalhães JP, Migeot V, Mainfroid V, de Longueville F, Remacle J, Toussaint O (2004) No increase in senescence-associated beta-galactosidase activity in Werner syndrome fibroblasts after exposure to H2O2. In: de Grey ADNJ (ed.), Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May Be Foreseeable. Annals of the New York Academy of Sciences, Vol. 1019, pp. 375-378.

de Magalhães JP, Toussaint O (2004) How bioinformatics can help reverse engineer human aging. Ageing Research Reviews 3:125-141.

de Magalhães JP (2004) The Dream of Elixir Vitae. In: Immortality Institute (ed.), The Scientific Conquest of Death: Essays on Infinite Lifespans. Libros En Red, Buenos Aires, pp. 47-62. [Adapted version]

de Magalhães JP (2004) Modelling human ageing: role of telomeres in stress-induced premature senescence and design of anti-ageing strategies. Doctoral thesis, University of Namur, Department of Biology, Namur, Belgium. 2003

de Magalhães JP (2003) Winning the war against aging. The Futurist, 37:48-50. [Adapted version]

de Magalhães JP (2003) Is mammalian aging genetically controlled? Biogerontology 4:119-120. 2002

de Magalhães JP, Chainiaux F, Remacle J, Toussaint O (2002) Stress-induced premature senescence in BJ and hTERT-BJ1 human fibroblasts. FEBS Letters 523:157-162.

Chainiaux F, Magalhaes JP, Eliaers F, Remacle J, Toussaint O (2002) UV-B induced premature senescence of human diploid skin fibroblasts. International Journal of Biochemistry & Cell Biology 34:1331-1339.

de Magalhães JP, Toussaint O (2002) The evolution of mammalian aging. Experimental Gerontology 37:769-775. 2001

Frippiat C, Chen QM, Zdanov S, Magalhaes JP, Remacle J, Toussaint O (2001) Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. Journal of Biological Chemistry 276:2531-2537.

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