Mag Lab

Exterior view of the Bioscience Building

Welcome to the OpenWetWare representation of Joao Pedro de Magalhaes Lab (Mag Lab). We are a highly interdisciplinary and international team, located in the heart of Liverpool (United Kingdom) and using in silico, in vitro as well as in vivo approaches to analyze and solve ageing.

Ageing Research

Scientists

Cloudy

• Introduction to Biogerontology
• Integrative Genomics of Ageing Group
• Research
• Resources
• Puplications
• People
• Vacancies
• Links
• Contact
• Head of the Group
• HAGR (Human Ageing Genomic Resources)
• GeneAge
• AnAge

Useful Links For Prospective Students

• The University of Liverpool
• School of Biological Sciences
• Graduate School
• Postgraduate School
• Postgraduate Handbook

Bioinformatics Tools

Programming Language

• Bio-Linux

People

• Daniel A. Wuttke

Collaborations

• Dr. Alan Morgan, School of Biomedical Sciences

News & Literature

1. Brunet A. Cancer: When restriction is good. Nature. 2009 Apr 9;458(7239):713-4. DOI:10.1038/458713a |
2. Kalaany NY and Sabatini DM. Tumours with PI3K activation are resistant to dietary restriction. Nature. 2009 Apr 9;458(7239):725-31. DOI:10.1038/nature07782 |
3. Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, and Madeo F. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009 Nov;11(11):1305-14. DOI:10.1038/ncb1975 |
4. Zid BM, Rogers AN, Katewa SD, Vargas MA, Kolipinski MC, Lu TA, Benzer S, and Kapahi P. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell. 2009 Oct 2;139(1):149-60. DOI:10.1016/j.cell.2009.07.034 |

   Translating Dietary Restriction into Long Life PaperFlick Supporting Documents

5. Veatch JR, McMurray MA, Nelson ZW, and Gottschling DE. Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell. 2009 Jun 26;137(7):1247-58. DOI:10.1016/j.cell.2009.04.014 |

   Mitochondrial Links to Genomic Instability in Aging PaperFlick

• Nature Web Focus on Ageing
• Nature Podcast on Ageing
• NPG library on Ageing

Publications

1. de Magalhães JP and Faragher RG. Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity. Bioessays. 2008 Jun;30(6):567-78. DOI:10.1002/bies.20760 |
2. de Magalhães JP, Budovsky A, Lehmann G, Costa J, Li Y, Fraifeld V, and Church GM. The Human Ageing Genomic Resources: online databases and tools for biogerontologists. Aging Cell. 2009 Feb;8(1):65-72. DOI:10.1111/j.1474-9726.2008.00442.x |
3. de Magalhães JP. Ageing research in the post-genome era: new technologies for an old problem. SEB Exp Biol Ser. 2009;62:99-115.
4. de Magalhães JP, Curado J, and Church GM. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics. 2009 Apr 1;25(7):875-81. DOI:10.1093/bioinformatics/btp073 |
5. de Magalhães JP and Costa J. A database of vertebrate longevity records and their relation to other life-history traits. J Evol Biol. 2009 Aug;22(8):1770-4. DOI:10.1111/j.1420-9101.2009.01783.x |
6. de Magalhães JP, Sedivy JM, Finch CE, Austad SN, and Church GM. A proposal to sequence genomes of unique interest for research on aging. J Gerontol A Biol Sci Med Sci. 2007 Jun;62(6):583-4. DOI:10.1093/gerona/62.6.583 |
7. de Magalhães JP and Church GM. Analyses of human-chimpanzee orthologous gene pairs to explore evolutionary hypotheses of aging. Mech Ageing Dev. 2007 May-Jun;128(5-6):355-64. DOI:10.1016/j.mad.2007.03.004 |
8. de Magalhães JP, Costa J, and Church GM. An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts. J Gerontol A Biol Sci Med Sci. 2007 Feb;62(2):149-60. DOI:10.1093/gerona/62.2.149 |
9. de Magalhães JP and Church GM. Cells discover fire: employing reactive oxygen species in development and consequences for aging. Exp Gerontol. 2006 Jan;41(1):1-10. DOI:10.1016/j.exger.2005.09.002 |
10. de Magalhães JP and Church GM. Genomes optimize reproduction: aging as a consequence of the developmental program. Physiology (Bethesda). 2005 Aug;20:252-9. DOI:10.1152/physiol.00010.2005 |
11. de Magalhães JP and Sandberg A. Cognitive aging as an extension of brain development: a model linking learning, brain plasticity, and neurodegeneration. Mech Ageing Dev. 2005 Oct;126(10):1026-33. DOI:10.1016/j.mad.2005.04.004 |
12. de Magalhães JP. Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations. Ageing Res Rev. 2005 Jan;4(1):1-22. DOI:10.1016/j.arr.2004.05.003 |
13. de Magalhães JP, Costa J, and Toussaint O. HAGR: the Human Ageing Genomic Resources. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D537-43. DOI:10.1093/nar/gki017 |
14. de Magalhães JP, Chainiaux F, de Longueville F, Mainfroid V, Migeot V, Marcq L, Remacle J, Salmon M, and Toussaint O. Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase. Exp Gerontol. 2004 Sep;39(9):1379-89. DOI:10.1016/j.exger.2004.06.004 |
15. de Magalhães JP, Cabral JA, and Magalhães D. The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging. Genetics. 2005 Jan;169(1):265-74. DOI:10.1534/genetics.104.032292 |
16. de Magalhães JP. From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing. Exp Cell Res. 2004 Oct 15;300(1):1-10. DOI:10.1016/j.yexcr.2004.07.006 |
17. de Magalhães JP and Toussaint O. Telomeres and telomerase: a modern fountain of youth?. Rejuvenation Res. 2004 Summer;7(2):126-33. DOI:10.1089/1549168041553044 |
18. de Magalhães JP and Toussaint O. GenAge: a genomic and proteomic network map of human ageing. FEBS Lett. 2004 Jul 30;571(1-3):243-7. DOI:10.1016/j.febslet.2004.07.006 |
19. de Magalhães JP, Migeot V, Mainfroid V, de Longueville F, Remacle J, and Toussaint O. No increase in senescence-associated beta-galactosidase activity in Werner syndrome fibroblasts after exposure to H2O2. Ann N Y Acad Sci. 2004 Jun;1019:375-8. DOI:10.1196/annals.1297.066 |
20. de Magalhães JP and Toussaint O. How bioinformatics can help reverse engineer human aging. Ageing Res Rev. 2004 Apr;3(2):125-41. DOI:10.1016/j.arr.2003.08.006 |
21. de Magalhães JP. Is mammalian aging genetically controlled?. Biogerontology. 2003;4(2):119-20. DOI:10.1023/a:1023356005749 |
22. de Magalhães JP and Toussaint O. The evolution of mammalian aging. Exp Gerontol. 2002 Jun;37(6):769-75. DOI:10.1016/s0531-5565(02)00008-6 |
23. de Magalhães JP, Chainiaux F, Remacle J, and Toussaint O. Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts. FEBS Lett. 2002 Jul 17;523(1-3):157-62. DOI:10.1016/s0014-5793(02)02973-3 |
24. Dumont P, Royer V, Pascal T, Dierick JF, Chainiaux F, Frippiat C, de Magalhaes JP, Eliaers F, Remacle J, and Toussaint O. Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence. FEBS Lett. 2001 Aug 3;502(3):109-12. DOI:10.1016/s0014-5793(01)02679-5 |
25. ISBN:9780415419543
26. ISBN:9780203866740