Mag Lab

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Exterior view of the Bioscience Building

Welcome to the lab wiki of the Integrative Genomics of Ageing Group. We are a highly interdisciplinary and international team, located in the heart of Liverpool (United Kingdom) and using in silico, in vitro as well as in vivo approaches to study the biology and genetics of ageing. The group's PI is Joao Pedro de Magalhaes, hence the name Mag Lab.

About our lab

Scientists

Useful Links For Prospective Students

Night time lapse of the Bioscience Building

Bioinformatics Tools

Programming Language

People

Collaborations

News & Literature

  1. Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM, Edsall L, Antosiewicz-Bourget J, Stewart R, Ruotti V, Millar AH, Thomson JA, Ren B, and Ecker JR. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature. 2009 Nov 19;462(7271):315-22. DOI:10.1038/nature08514 | PubMed ID:19829295 | HubMed [Paper6]

    First step to understand the methylation pattern of cells and how it alters in time.

    This is intersting especially for two aspects: The embryonal development & the ageing process

  2. Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, and Madeo F. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009 Nov;11(11):1305-14. DOI:10.1038/ncb1975 | PubMed ID:19801973 | HubMed [Paper5]

    Spermidine is a small molecule, just a polyamine with a very simple structure: C7H19N3

  3. Zid BM, Rogers AN, Katewa SD, Vargas MA, Kolipinski MC, Lu TA, Benzer S, and Kapahi P. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell. 2009 Oct 2;139(1):149-60. DOI:10.1016/j.cell.2009.07.034 | PubMed ID:19804760 | HubMed [Paper4]

    Translating Dietary Restriction into Long Life PaperFlick Supporting Documents

  4. Veatch JR, McMurray MA, Nelson ZW, and Gottschling DE. Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell. 2009 Jun 26;137(7):1247-58. DOI:10.1016/j.cell.2009.04.014 | PubMed ID:19563757 | HubMed [Paper3]

    Mitochondrial Links to Genomic Instability in Aging PaperFlick

  5. Brunet A. Cancer: When restriction is good. Nature. 2009 Apr 9;458(7239):713-4. DOI:10.1038/458713a | PubMed ID:19360073 | HubMed [Paper2]

    Nice essay about connections of cancer, ageing and CR

  6. Kalaany NY and Sabatini DM. Tumours with PI3K activation are resistant to dietary restriction. Nature. 2009 Apr 9;458(7239):725-31. DOI:10.1038/nature07782 | PubMed ID:19279572 | HubMed [Paper1]

    I think xenografts are a very bad model of cancer formation [DW].

All Medline abstracts: PubMed | HubMed

Publications

  1. de Magalhães JP, Sedivy JM, Finch CE, Austad SN, and Church GM. A proposal to sequence genomes of unique interest for research on aging. J Gerontol A Biol Sci Med Sci. 2007 Jun;62(6):583-4. DOI:10.1093/gerona/62.6.583 | PubMed ID:17595413 | HubMed [Paper6]
  2. de Magalhães JP and Faragher RG. Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity. Bioessays. 2008 Jun;30(6):567-78. DOI:10.1002/bies.20760 | PubMed ID:18478536 | HubMed [Paper5]
  3. de Magalhães JP, Budovsky A, Lehmann G, Costa J, Li Y, Fraifeld V, and Church GM. The Human Ageing Genomic Resources: online databases and tools for biogerontologists. Aging Cell. 2009 Feb;8(1):65-72. DOI:10.1111/j.1474-9726.2008.00442.x | PubMed ID:18986374 | HubMed [Paper4]
  4. de Magalhães JP. Ageing research in the post-genome era: new technologies for an old problem. SEB Exp Biol Ser. 2009;62:99-115. PubMed ID:19418994 | HubMed [Paper3]
  5. de Magalhães JP, Curado J, and Church GM. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics. 2009 Apr 1;25(7):875-81. DOI:10.1093/bioinformatics/btp073 | PubMed ID:19189975 | HubMed [Paper2]
  6. de Magalhães JP and Costa J. A database of vertebrate longevity records and their relation to other life-history traits. J Evol Biol. 2009 Aug;22(8):1770-4. DOI:10.1111/j.1420-9101.2009.01783.x | PubMed ID:19522730 | HubMed [Paper1]
  7. de Magalhães JP and Church GM. Analyses of human-chimpanzee orthologous gene pairs to explore evolutionary hypotheses of aging. Mech Ageing Dev. 2007 May-Jun;128(5-6):355-64. DOI:10.1016/j.mad.2007.03.004 | PubMed ID:17459455 | HubMed [Paper7]
  8. de Magalhães JP, Costa J, and Church GM. An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts. J Gerontol A Biol Sci Med Sci. 2007 Feb;62(2):149-60. DOI:10.1093/gerona/62.2.149 | PubMed ID:17339640 | HubMed [Paper8]
  9. de Magalhães JP and Church GM. Cells discover fire: employing reactive oxygen species in development and consequences for aging. Exp Gerontol. 2006 Jan;41(1):1-10. DOI:10.1016/j.exger.2005.09.002 | PubMed ID:16226003 | HubMed [Paper9]
  10. de Magalhães JP and Church GM. Genomes optimize reproduction: aging as a consequence of the developmental program. Physiology (Bethesda). 2005 Aug;20:252-9. DOI:10.1152/physiol.00010.2005 | PubMed ID:16024513 | HubMed [Paper10]
  11. de Magalhães JP and Sandberg A. Cognitive aging as an extension of brain development: a model linking learning, brain plasticity, and neurodegeneration. Mech Ageing Dev. 2005 Oct;126(10):1026-33. DOI:10.1016/j.mad.2005.04.004 | PubMed ID:15946728 | HubMed [Paper11]
  12. de Magalhães JP. Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations. Ageing Res Rev. 2005 Jan;4(1):1-22. DOI:10.1016/j.arr.2004.05.003 | PubMed ID:15619467 | HubMed [Paper12]
  13. de Magalhães JP, Costa J, and Toussaint O. HAGR: the Human Ageing Genomic Resources. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D537-43. DOI:10.1093/nar/gki017 | PubMed ID:15608256 | HubMed [Paper13]
  14. de Magalhães JP, Chainiaux F, de Longueville F, Mainfroid V, Migeot V, Marcq L, Remacle J, Salmon M, and Toussaint O. Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase. Exp Gerontol. 2004 Sep;39(9):1379-89. DOI:10.1016/j.exger.2004.06.004 | PubMed ID:15489061 | HubMed [Paper14]
  15. de Magalhães JP, Cabral JA, and Magalhães D. The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging. Genetics. 2005 Jan;169(1):265-74. DOI:10.1534/genetics.104.032292 | PubMed ID:15466429 | HubMed [Paper15]
  16. de Magalhães JP. From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing. Exp Cell Res. 2004 Oct 15;300(1):1-10. DOI:10.1016/j.yexcr.2004.07.006 | PubMed ID:15383309 | HubMed [Paper16]
  17. de Magalhães JP and Toussaint O. Telomeres and telomerase: a modern fountain of youth?. Rejuvenation Res. 2004 Summer;7(2):126-33. DOI:10.1089/1549168041553044 | PubMed ID:15312299 | HubMed [Paper17]
  18. de Magalhães JP and Toussaint O. GenAge: a genomic and proteomic network map of human ageing. FEBS Lett. 2004 Jul 30;571(1-3):243-7. DOI:10.1016/j.febslet.2004.07.006 | PubMed ID:15280050 | HubMed [Paper18]
  19. de Magalhães JP, Migeot V, Mainfroid V, de Longueville F, Remacle J, and Toussaint O. No increase in senescence-associated beta-galactosidase activity in Werner syndrome fibroblasts after exposure to H2O2. Ann N Y Acad Sci. 2004 Jun;1019:375-8. DOI:10.1196/annals.1297.066 | PubMed ID:15247048 | HubMed [Paper19]
  20. de Magalhães JP and Toussaint O. How bioinformatics can help reverse engineer human aging. Ageing Res Rev. 2004 Apr;3(2):125-41. DOI:10.1016/j.arr.2003.08.006 | PubMed ID:15177050 | HubMed [Paper20]
  21. de Magalhães JP. Is mammalian aging genetically controlled?. Biogerontology. 2003;4(2):119-20. DOI:10.1023/a:1023356005749 | PubMed ID:12766537 | HubMed [Paper21]
  22. de Magalhães JP and Toussaint O. The evolution of mammalian aging. Exp Gerontol. 2002 Jun;37(6):769-75. DOI:10.1016/s0531-5565(02)00008-6 | PubMed ID:12175477 | HubMed [Paper22]
  23. de Magalhães JP, Chainiaux F, Remacle J, and Toussaint O. Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts. FEBS Lett. 2002 Jul 17;523(1-3):157-62. DOI:10.1016/s0014-5793(02)02973-3 | PubMed ID:12123824 | HubMed [Paper23]
  24. Dumont P, Royer V, Pascal T, Dierick JF, Chainiaux F, Frippiat C, de Magalhaes JP, Eliaers F, Remacle J, and Toussaint O. Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence. FEBS Lett. 2001 Aug 3;502(3):109-12. DOI:10.1016/s0014-5793(01)02679-5 | PubMed ID:11583109 | HubMed [Paper24]
  25. ISBN:9780415419543 [Book1]
  26. ISBN:9780203866740 [Book2]

All Medline abstracts: PubMed | HubMed

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