Malaria: Difference between revisions
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***Gk2 - HVR1 (NANP)5 subsitution | ***Gk2 - HVR1 (NANP)5 subsitution | ||
***GKIII-2 - HVR5 T* insertion between hexon AAs 272 and 273 | ***GKIII-2 - HVR5 T* insertion between hexon AAs 272 and 273 | ||
*Ad5 late gene expression mutants | |||
**LSA3 (liver stage antigen 3) | |||
***FFH3 - hexon splice aceptor |
Revision as of 08:40, 30 August 2006
Live replicating adenovirus malaria vaccine
Plasmids
- Progenitor - pTG3602 - whole Ad5 genome with pPolyII linking ITRs. Cut with PacI to liberate infectious Ad5 DNA
all plasmids are AmpR
Viruses
- Ad5 full genome capsid display mutants
- CS (circumsporozoite antigent) mutants
- Gk2 - HVR1 (NANP)5 subsitution
- GKIII-2 - HVR5 T* insertion between hexon AAs 272 and 273
- CS (circumsporozoite antigent) mutants
- Ad5 late gene expression mutants
- LSA3 (liver stage antigen 3)
- FFH3 - hexon splice aceptor
- LSA3 (liver stage antigen 3)