Malaria
From OpenWetWare
Live replicating adenovirus malaria vaccine
Plasmids
- Progenitor - pTG3602 - whole Ad5 genome with pPolyII linking ITRs. Cut with PacI to liberate infectious Ad5 DNA
all plasmids are AmpR
Viruses
- Ad5 full genome capsid display mutants
- CS (circumsporozoite antigent) mutants
- Gk2 - HVR1 (NANP)5 subsitution
- GKIII-2 - HVR5 T* insertion between hexon AAs 272 and 273
- CS (circumsporozoite antigent) mutants