Matt Gethers: Difference between revisions
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==UROP Projects== | ==UROP Projects== | ||
[[/20.380 HIV Project|20.380 HIV Project]] | |||
[[/Articles of General Interest| Articles of General Interest]] | |||
[[/Articles to Read|Articles to Read]] | |||
[[Endy:Translation demand | Translation Demand]] | [[Endy:Translation demand | Translation Demand]] | ||
[http://bcanton.private.openwetware.org/wiki/Lab_Notebook/Matt/Mitochondria_Project Mitochondrial Engineering] | [http://bcanton.private.openwetware.org/wiki/Lab_Notebook/Matt/Mitochondria_Project Mitochondrial Engineering] | ||
[[/CRI, Thailand| CRI Thailand]] | |||
[[/Matt's Stanford Freezer Stocks|Matt's Stanford Freezer Stocks]] | |||
[[/OWW Syntax| OWW Syntax]] | |||
[[/Eloranta Ideas|Eloranta Ideas]] | |||
==20.109 Work== | ==20.109 Work== | ||
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*[[User:Mgethers/Research Proposal|Research Proposal]] | *[[User:Mgethers/Research Proposal|Research Proposal]] | ||
==Class projects== | |||
[[/20.310 Term Paper| 20.310 Term Paper]] | |||
==20.310 Project== | ==20.310 Project== | ||
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#Carragher2 pmid=3351927 | #Carragher2 pmid=3351927 | ||
#Carragher3 pmid=3351930 | #Carragher3 pmid=3351930 | ||
#Turner pmid=12638863 | |||
#Wang pmid=11812133 | #Wang pmid=11812133 | ||
</biblio> | </biblio> | ||
Treatments exist for preventive and palliative treatment of sickle cell episodes, but no treatment has yet been developed to mitigate the effects of an attack once it has started. We need a way of dealing with Hbs fibers once they have polymerized. We feel we can develop a treatment for an ongoing attack by addressing the biomechanical basis of the pathology. | Treatments exist for preventive and palliative treatment of sickle cell episodes, but no treatment has yet been developed to mitigate the effects of an attack once it has started. We need a way of dealing with Hbs fibers once they have polymerized. We feel we can develop a treatment for an ongoing attack by addressing the biomechanical basis of the pathology. | ||
Latest revision as of 05:22, 18 February 2009
I'm currently a sophomore in course 20. When I'm behaving myself, I'm allowed to work in the Endy Lab at MIT. I have links to my UROP projects and 20.109 work directly below.
UROP Projects
Matt's Stanford Freezer Stocks
20.109 Work
Class projects
20.310 Project
- Galkin O, Pan W, Filobelo L, Hirsch RE, Nagel RL, and Vekilov PG. Two-step mechanism of homogeneous nucleation of sickle cell hemoglobin polymers. Biophys J. 2007 Aug 1;93(3):902-13. DOI:10.1529/biophysj.106.103705 |
- Carragher B, Bluemke DA, Gabriel B, Potel MJ, and Josephs R. Structural analysis of polymers of sickle cell hemoglobin. I. Sickle hemoglobin fibers. J Mol Biol. 1988 Jan 20;199(2):315-31. DOI:10.1016/0022-2836(88)90316-6 |
- Bluemke DA, Carragher B, Potel MJ, and Josephs R. Structural analysis of polymers of sickle cell hemoglobin. II. Sickle hemoglobin macrofibers. J Mol Biol. 1988 Jan 20;199(2):333-48. DOI:10.1016/0022-2836(88)90317-8 |
- Carragher B, Bluemke DA, Becker M, McDade WA, Potel MJ, and Josephs R. Structural analysis of polymers of sickle cell hemoglobin. III. Fibers within fascicles. J Mol Biol. 1988 Jan 20;199(2):383-8. DOI:10.1016/0022-2836(88)90322-1 |
- Jones CW, Wang JC, Ferrone FA, Briehl RW, and Turner MS. Interactions between sickle hemoglobin fibers. Faraday Discuss. 2003;123:221-36; discussion 303-22, 419-21. DOI:10.1039/b207388a |
- Wang JC, Turner MS, Agarwal G, Kwong S, Josephs R, Ferrone FA, and Briehl RW. Micromechanics of isolated sickle cell hemoglobin fibers: bending moduli and persistence lengths. J Mol Biol. 2002 Jan 25;315(4):601-12. DOI:10.1006/jmbi.2001.5130 |
Treatments exist for preventive and palliative treatment of sickle cell episodes, but no treatment has yet been developed to mitigate the effects of an attack once it has started. We need a way of dealing with Hbs fibers once they have polymerized. We feel we can develop a treatment for an ongoing attack by addressing the biomechanical basis of the pathology.
