Melissa Kemp

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'''Melissa Kemp''' (BE postdoctoral), in collaboration Dr. Cindy Stokes (Entelos)
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'''Melissa Kemp''' (BE postdoctoral), in collaboration with Lucia Wille, John Burke, Christina Lewis
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Experimental and computational modeling studies of lymphocyte signaling. Investigation of the apoptotic and cytokine responses resulting from stimulation of T cells at the T cell receptor via ligands of varying affinity. Network analysis of the T cell activation pathway using high throughput kinase assays.
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Investigation of the signaling dynamics and cytokine responses resulting from stimulation of the T cell receptor via ligands of varying avidity. Using a systems approach, we have generated a large dataset characterizing the multivariate relationships between ligand avidity, signaling dynamics and IL-2 production in a murine T cell hybridoma line. Partial least squares regression analysis leads to a predictive model of IL-2 production in our system.
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Revision as of 12:00, 6 December 2005

Lauffenburger Lab

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Melissa Kemp (BE postdoctoral), in collaboration with Lucia Wille, John Burke, Christina Lewis

Investigation of the signaling dynamics and cytokine responses resulting from stimulation of the T cell receptor via ligands of varying avidity. Using a systems approach, we have generated a large dataset characterizing the multivariate relationships between ligand avidity, signaling dynamics and IL-2 production in a murine T cell hybridoma line. Partial least squares regression analysis leads to a predictive model of IL-2 production in our system.

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