Melissa Kemp

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'''Melissa Kemp''' (BE postdoctoral), in collaboration with Lucia Wille, John Burke, Christina Lewis
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''Investigation of the signaling dynamics and cytokine responses resulting from stimulation of the T cell receptor via ligands of varying avidity.'' Using a systems approach, we have generated a large dataset characterizing the multivariate relationships between ligand avidity, signaling dynamics and IL-2 production in a murine T cell hybridoma line. Partial least squares regression analysis leads to a predictive model of IL-2 production in our system.
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<font size="4">Melissa Lambeth Kemp</font size> <br><br>
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<font size="2">The Wallace H. Coulter Department of Biomedical Engineering<br>
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Georgia Tech and Emory University <br>
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315 Ferst Dr.<br>
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Atlanta, GA 30306-0535<br>
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melissa.kemp at bme.gatech.edu
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== Research Interests ==
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<blockquote>
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* Modeling and experimental testing of signal transduction pathway dynamics
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* Network analysis of protein-protein interactions
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* Biological switch mechanisms
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* T cell activation
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== Education==
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<blockquote>1993-97 B.S., M.I.T. <br>
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Nuclear engineering with a minor in biomedical engineering
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<br>
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<br>
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1997-2003 Ph.D., University of Washington <br>
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Bioengineering <br>
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My doctoral thesis focused on how skeletal muscle regulated glycogenolysis under anaerobic conditions by analyzing the biochemical pathway with computational modeling
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<br>
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<br>
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2003-2006 Postdoc, M.I.T. <br>
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Biological engineering <br>
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In collaboration with Lucia Wille, generated a predictive model of IL-2 response from T cell activation with varying avidity ligands
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== Publications ==
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<blockquote>
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<br>
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kemp+ML+OR+Lambeth+MJ&db=PubMed&orig_db=PubMed&filters=on&pmfilter_EDatLimit=10+Years PubMed Entries]
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Revision as of 16:58, 6 December 2006

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Melissa Lambeth Kemp


The Wallace H. Coulter Department of Biomedical Engineering
Georgia Tech and Emory University
315 Ferst Dr.
Atlanta, GA 30306-0535

melissa.kemp at bme.gatech.edu

Research Interests

  • Modeling and experimental testing of signal transduction pathway dynamics
  • Network analysis of protein-protein interactions
  • Biological switch mechanisms
  • T cell activation

Education

1993-97 B.S., M.I.T.
Nuclear engineering with a minor in biomedical engineering

1997-2003 Ph.D., University of Washington
Bioengineering
My doctoral thesis focused on how skeletal muscle regulated glycogenolysis under anaerobic conditions by analyzing the biochemical pathway with computational modeling

2003-2006 Postdoc, M.I.T.
Biological engineering
In collaboration with Lucia Wille, generated a predictive model of IL-2 response from T cell activation with varying avidity ligands

Publications


PubMed Entries
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