Welcome to the Min-Ho Kim's research group at Kent State University
The major focus of research interests in our laboratory is to develop therapeutics to promote the resolution of non-healing chronic wounds based on precise understanding of inflammatory response to tissue injury and infection. Many non-healing chronic wounds have been associated with chronic inflammation. A more detailed understanding of mechanisms controlling the inflammatory response and how inflammation directs the outcome of the healing process will provide therapeutics for tissue repair in chronic inflammatory diseases. Our long-term goals are to (1) understand the molecular and cellular mechanisms by which local inflammatory environmental cues alter phenotypic switch of tissue infiltrating innate immune cells and these cells functionally interact with mesenchymal stem cells, and (2) develop selective strategy to engineer microenvironmental cues towards tissue regeneration by utilizing micro/nano-engineered biomaterials that enable spatio-temporal control of inflammatory response. To achieve this goal, we combine interdisciplinary approaches of immuno-biology, stem cell biology, cellular and tissue engineering, and nano-bioengineering.