Nachury:Research

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(Vesicular transport to the primary cilium: basic principles)
(Vesicular transport to the primary cilium: basic principles)
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== Vesicular transport to the primary cilium: basic principles ==
== Vesicular transport to the primary cilium: basic principles ==
[[image:Cilium_Anderson.jpg|thumb|200px|left]]
[[image:Cilium_Anderson.jpg|thumb|200px|left]]
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The primary cilium is composed of a microtubule core enclosed within a membrane sheath, the ciliary membrane, that is continuous with the plasma membrane. Despite this continuity, ciliary and plasma membranes contain distinct complements of lipids and proteins, thus making the cilium a ''bona fide'' compartment exposed to the extracellular milieu. Consequently, the cilium has been compared to a "cellular antenna" that capture and transduces developmental signal to the inside of the cell.
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The primary cilium is composed of a microtubule core enclosed within a membrane sheath, the ciliary membrane, that is continuous with the plasma membrane. Despite this continuity, ciliary and plasma membranes contain distinct complements of lipids and proteins, thus making the cilium a ''bona fide'' compartment exposed to the extracellular milieu. Consequently, the cilium has been compared to a "cellular antenna" that capture and transduces developmental signals to the inside of the cell. But how do relevant signaling receptors reach the ciliary membrane instead of the plasma membrane? We have recently discovered two factors involved in vesicular transport
== Regulated transport to the primary cilium ==
== Regulated transport to the primary cilium ==

Revision as of 00:37, 11 January 2008

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Research

Vesicular transport to the primary cilium: basic principles

The primary cilium is composed of a microtubule core enclosed within a membrane sheath, the ciliary membrane, that is continuous with the plasma membrane. Despite this continuity, ciliary and plasma membranes contain distinct complements of lipids and proteins, thus making the cilium a bona fide compartment exposed to the extracellular milieu. Consequently, the cilium has been compared to a "cellular antenna" that capture and transduces developmental signals to the inside of the cell. But how do relevant signaling receptors reach the ciliary membrane instead of the plasma membrane? We have recently discovered two factors involved in vesicular transport

Regulated transport to the primary cilium


Discovery of novel ciliary signaling pathways


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