Nachury:Research - Revision history

Nachury:Research - Revision history http://www.openwetware.org/index.php?title=Nachury:Research&action=history Revision history for this page on the wiki en MediaWiki 1.13.2 Thu, 23 May 2013 07:18:06 GMT Maxence V. Nachury: /* Vesicular transport to the primary cilium */ http://www.openwetware.org/index.php?title=Nachury:Research&diff=192556&oldid=prev <p><span class="autocomment">Vesicular transport to the primary cilium</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 05:32, 25 March 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 4:</td> <td colspan="2" class="diff-lineno">Line 4:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Vesicular transport to the primary cilium ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Vesicular transport to the primary cilium ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:Cilium_Anderson.jpg|thumb|200px|left]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:Cilium_Anderson.jpg|thumb|200px|left]]</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The membrane of the primary cilium is continuous with the plasma membrane. Despite this continuity, ciliary and plasma membranes contain distinct complements of lipids and proteins, thus making the cilium a ''bona fide'' compartment exposed to the extracellular milieu. Consequently, the cilium has been compared to a "cellular antenna" that captures and transduces developmental signals to the inside of the cell. But how do the relevant signaling receptors reach the ciliary membrane instead of the plasma membrane? This question of vesicular targeting to the cilium has recently been illuminated by our discovery of two key ciliogenic factors, the BBSome and Rab8. Consistent with the general paradigm of the small GTPases of the Rab family, Rab8 likely mediates the docking and fusion of transport vesicles with the base of the primary cilium. But where and when does Rab8 precisely function in this transport process? What effectors does Rab8 utilize to specifically target vesicles to the primary cilium? How is the subsequent step of entry into the cilium proper linked to this fusion step? <del class="diffchange diffchange-inline">These are the questions we aim to study.</del><br> Conversely to Rab8, the molecular activity of the BBSome is still very poorly understood. The BBSome is a complex of 7 proteins encoded by genes defective in Bardet-Biedl Syndrome (BBS), an obesity/retinopathy ciliopathy. We plan to develop ''in vitro'' and ''in vivo'' assays to pinpoint the role of the BBSome in transport to the cilium and to define what type of molecular machine the BBSome represents. <del class="diffchange diffchange-inline">Furthermore</del>, a structural analysis of the BBSome has been initiated in collaboration with the lab of [http://garcia-lab.stanford.edu/ Chris Garcia].</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The membrane of the primary cilium is continuous with the plasma membrane. Despite this continuity, ciliary and plasma membranes contain distinct complements of lipids and proteins, thus making the cilium a ''bona fide'' compartment exposed to the extracellular milieu. Consequently, the cilium has been compared to a "cellular antenna" that captures and transduces developmental signals to the inside of the cell. But how do the relevant signaling receptors reach the ciliary membrane instead of the plasma membrane? This question of vesicular targeting to the cilium has recently been illuminated by our discovery of two key ciliogenic factors, the BBSome and Rab8. Consistent with the general paradigm of the small GTPases of the Rab family, Rab8 likely mediates the docking and fusion of transport vesicles with the base of the primary cilium. But where and when does Rab8 precisely function in this transport process? What effectors does Rab8 utilize to specifically target vesicles to the primary cilium? How is the subsequent step of entry into the cilium proper linked to this fusion step?<br> Conversely to Rab8, the molecular activity of the BBSome is still very poorly understood. The BBSome is a complex of 7 proteins encoded by genes defective in Bardet-Biedl Syndrome (BBS), an obesity/retinopathy ciliopathy. We plan to develop ''in vitro'' and ''in vivo'' assays to pinpoint the role of the BBSome in transport to the cilium and to define what type of molecular machine the BBSome represents. <ins class="diffchange diffchange-inline">To this end</ins>, a structural analysis of the BBSome has been initiated in collaboration with the lab of [http://garcia-lab.stanford.edu/ Chris Garcia].</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Regulated traffic to and from the primary cilium ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Regulated traffic to and from the primary cilium ==</div></td></tr>  </table> Tue, 25 Mar 2008 05:32:41 GMT Maxence V. Nachury http://www.openwetware.org/wiki/Talk:Nachury:Research Maxence V. Nachury: /* Vesicular transport to the primary cilium */ http://www.openwetware.org/index.php?title=Nachury:Research&diff=178930&oldid=prev <p><span class="autocomment">Vesicular transport to the primary cilium</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 02:16, 15 January 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 4:</td> <td colspan="2" class="diff-lineno">Line 4:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Vesicular transport to the primary cilium ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Vesicular transport to the primary cilium ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:Cilium_Anderson.jpg|thumb|200px|left]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:Cilium_Anderson.jpg|thumb|200px|left]]</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The membrane of the primary cilium is continuous with the plasma membrane. Despite this continuity, ciliary and plasma membranes contain distinct complements of lipids and proteins, thus making the cilium a ''bona fide'' compartment exposed to the extracellular milieu. Consequently, the cilium has been compared to a "cellular antenna" that <del class="diffchange diffchange-inline">capture </del>and transduces developmental signals to the inside of the cell. But how do the relevant signaling receptors reach the ciliary membrane instead of the plasma membrane? This question of vesicular targeting to the cilium has recently been illuminated by our discovery of two key ciliogenic factors, the BBSome and Rab8. Consistent with the general paradigm of the small GTPases of the Rab family, Rab8 likely mediates the docking and fusion of transport vesicles with the base of the primary cilium. But where and when does Rab8 precisely function in this transport process? What effectors does Rab8 utilize to specifically target vesicles to the primary cilium? How is the subsequent step of entry into the cilium proper linked to this fusion step? These are the questions we aim to study.<br> Conversely to Rab8, the molecular activity of the BBSome is still very poorly understood. The BBSome is a complex of 7 proteins encoded by genes defective in Bardet-Biedl Syndrome (BBS), an obesity/retinopathy ciliopathy. We plan to develop ''in vitro'' and ''in vivo'' assays to pinpoint the role of the BBSome in transport to the cilium and to define what type of molecular machine the BBSome represents. Furthermore, a structural analysis of the BBSome has been initiated in collaboration with the lab of [http://garcia-lab.stanford.edu/ Chris Garcia].</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The membrane of the primary cilium is continuous with the plasma membrane. Despite this continuity, ciliary and plasma membranes contain distinct complements of lipids and proteins, thus making the cilium a ''bona fide'' compartment exposed to the extracellular milieu. Consequently, the cilium has been compared to a "cellular antenna" that <ins class="diffchange diffchange-inline">captures </ins>and transduces developmental signals to the inside of the cell. But how do the relevant signaling receptors reach the ciliary membrane instead of the plasma membrane? This question of vesicular targeting to the cilium has recently been illuminated by our discovery of two key ciliogenic factors, the BBSome and Rab8. Consistent with the general paradigm of the small GTPases of the Rab family, Rab8 likely mediates the docking and fusion of transport vesicles with the base of the primary cilium. But where and when does Rab8 precisely function in this transport process? What effectors does Rab8 utilize to specifically target vesicles to the primary cilium? How is the subsequent step of entry into the cilium proper linked to this fusion step? These are the questions we aim to study.<br> Conversely to Rab8, the molecular activity of the BBSome is still very poorly understood. The BBSome is a complex of 7 proteins encoded by genes defective in Bardet-Biedl Syndrome (BBS), an obesity/retinopathy ciliopathy. We plan to develop ''in vitro'' and ''in vivo'' assays to pinpoint the role of the BBSome in transport to the cilium and to define what type of molecular machine the BBSome represents. Furthermore, a structural analysis of the BBSome has been initiated in collaboration with the lab of [http://garcia-lab.stanford.edu/ Chris Garcia].</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Regulated traffic to and from the primary cilium ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Regulated traffic to and from the primary cilium ==</div></td></tr>  </table> Tue, 15 Jan 2008 02:16:06 GMT Maxence V. Nachury http://www.openwetware.org/wiki/Talk:Nachury:Research Maxence V. Nachury: /* Discovery of novel ciliary signaling pathways */ http://www.openwetware.org/index.php?title=Nachury:Research&diff=178176&oldid=prev <p><span class="autocomment">Discovery of novel ciliary signaling pathways</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 22:06, 11 January 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 17:</td> <td colspan="2" class="diff-lineno">Line 17:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Discovery of novel ciliary signaling pathways ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Discovery of novel ciliary signaling pathways ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:BBS_Organs.jpg|thumb|200px|left]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:BBS_Organs.jpg|thumb|200px|left]]</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Given the variety of symptoms found in Bardet-Biedl syndrome, it is expected that organ-specific developmental pathways are defective in BBS patients. Following our hypothesis that the BBSome acts in vesicular transport to the primary cilium, one would predict that the BBSome targets tissue-specific signaling receptors to the ciliary membrane (depicted in green on the figure) and that a defective BBSome will render these pathways inactive. In collaboration with the lab of [http://www.hhmi.org/research/investigators/sheffield.html Val Sheffield], we have engineered a mouse strain that will allow us to <del class="diffchange diffchange-inline">biochemical </del>isolate the BBSome and its associated factors. We will subject specific tissues to in-depth proteomics analysis of the BBSome with the aim of identifying specific signaling factors. Our goal is to uncover novel signaling pathways that utilize the cilium for signal capture or processing and to shed light on the molecular bais of symptoms such as obesity and retinal degeneration.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Given the variety of symptoms found in Bardet-Biedl syndrome, it is expected that organ-specific developmental pathways are defective in BBS patients. Following our hypothesis that the BBSome acts in vesicular transport to the primary cilium, one would predict that the BBSome targets tissue-specific signaling receptors to the ciliary membrane (depicted in green on the figure) and that a defective BBSome will render these pathways inactive. In collaboration with the lab of [http://www.hhmi.org/research/investigators/sheffield.html Val Sheffield], we have engineered a mouse strain that will allow us to <ins class="diffchange diffchange-inline">biochemically </ins>isolate the BBSome and its associated factors. We will subject specific tissues to in-depth proteomics analysis of the BBSome with the aim of identifying specific signaling factors. Our goal is to uncover novel signaling pathways that utilize the cilium for signal capture or processing and to shed light on the molecular bais of symptoms such as obesity and retinal degeneration.</div></td></tr>  </table> Fri, 11 Jan 2008 22:06:13 GMT Maxence V. Nachury http://www.openwetware.org/wiki/Talk:Nachury:Research Maxence V. Nachury: /* Discovery of novel ciliary signaling pathways */ http://www.openwetware.org/index.php?title=Nachury:Research&diff=178156&oldid=prev <p><span class="autocomment">Discovery of novel ciliary signaling pathways</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:40, 11 January 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 17:</td> <td colspan="2" class="diff-lineno">Line 17:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Discovery of novel ciliary signaling pathways ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Discovery of novel ciliary signaling pathways ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:BBS_Organs.jpg|thumb|200px|left]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:BBS_Organs.jpg|thumb|200px|left]]</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Given the variety of symptoms found in Bardet-Biedl syndrome, it is expected that organ-specific developmental pathways are defective in BBS patients. Following our hypothesis that the BBSome acts in vesicular transport to the primary cilium, one would predict that the BBSome targets tissue-specific signaling receptors to the ciliary membrane (depicted in green on the figure) and that a defective BBSome will render these pathways inactive. In collaboration with the lab of [http://www.hhmi.org/research/investigators/sheffield.html Val Sheffield], we have engineered a mouse strain that will allow us to biochemical isolate the BBSome and its associated factors.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Given the variety of symptoms found in Bardet-Biedl syndrome, it is expected that organ-specific developmental pathways are defective in BBS patients. Following our hypothesis that the BBSome acts in vesicular transport to the primary cilium, one would predict that the BBSome targets tissue-specific signaling receptors to the ciliary membrane (depicted in green on the figure) and that a defective BBSome will render these pathways inactive. In collaboration with the lab of [http://www.hhmi.org/research/investigators/sheffield.html Val Sheffield], we have engineered a mouse strain that will allow us to biochemical isolate the BBSome and its associated factors<ins class="diffchange diffchange-inline">. We will subject specific tissues to in-depth proteomics analysis of the BBSome with the aim of identifying specific signaling factors. Our goal is to uncover novel signaling pathways that utilize the cilium for signal capture or processing and to shed light on the molecular bais of symptoms such as obesity and retinal degeneration</ins>.</div></td></tr>  </table> Fri, 11 Jan 2008 21:40:17 GMT Maxence V. Nachury http://www.openwetware.org/wiki/Talk:Nachury:Research Maxence V. Nachury: /* Discovery of novel ciliary signaling pathways */ http://www.openwetware.org/index.php?title=Nachury:Research&diff=178154&oldid=prev <p><span class="autocomment">Discovery of novel ciliary signaling pathways</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:26, 11 January 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 17:</td> <td colspan="2" class="diff-lineno">Line 17:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Discovery of novel ciliary signaling pathways ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Discovery of novel ciliary signaling pathways ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:BBS_Organs.jpg|thumb|200px|left]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:BBS_Organs.jpg|thumb|200px|left]]</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Given the variety of symptoms found in Bardet-Biedl syndrome, it is expected that organ-specific developmental pathways are defective in BBS patients. Following our hypothesis that the BBSome acts in vesicular transport to the primary cilium, one would predict that the BBSome targets tissue-specific signaling receptors to the ciliary membrane (depicted in green on the figure) and that a defective BBSome will render these pathways inactive. In collaboration with the lab of [http://www.hhmi.org/research/investigators/sheffield.html<del class="diffchange diffchange-inline">/ </del>Val Sheffield], we have engineered a mouse strain that will allow us to biochemical isolate the BBSome and its associated factors.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Given the variety of symptoms found in Bardet-Biedl syndrome, it is expected that organ-specific developmental pathways are defective in BBS patients. Following our hypothesis that the BBSome acts in vesicular transport to the primary cilium, one would predict that the BBSome targets tissue-specific signaling receptors to the ciliary membrane (depicted in green on the figure) and that a defective BBSome will render these pathways inactive. In collaboration with the lab of [http://www.hhmi.org/research/investigators/sheffield.html Val Sheffield], we have engineered a mouse strain that will allow us to biochemical isolate the BBSome and its associated factors.</div></td></tr>  </table> Fri, 11 Jan 2008 21:26:10 GMT Maxence V. Nachury http://www.openwetware.org/wiki/Talk:Nachury:Research Maxence V. Nachury: /* Discovery of novel ciliary signaling pathways */ http://www.openwetware.org/index.php?title=Nachury:Research&diff=178153&oldid=prev <p><span class="autocomment">Discovery of novel ciliary signaling pathways</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:24, 11 January 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 17:</td> <td colspan="2" class="diff-lineno">Line 17:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Discovery of novel ciliary signaling pathways ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Discovery of novel ciliary signaling pathways ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:BBS_Organs.jpg|thumb|200px|left]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:BBS_Organs.jpg|thumb|200px|left]]</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>In collaboration with the lab of [http://www.hhmi.org/research/investigators/sheffield.html/ Val Sheffield], we have engineered a mouse strain that will allow us to biochemical isolate the BBSome and its associated factors. <del class="diffchange diffchange-inline">Given the variety of organ-specific pathologies found in Bardet-Biedl syndrome, it is expected that specific signaling pathways</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">Given the variety of symptoms found in Bardet-Biedl syndrome, it is expected that organ-specific developmental pathways are defective in BBS patients. Following our hypothesis that the BBSome acts in vesicular transport to the primary cilium, one would predict that the BBSome targets tissue-specific signaling receptors to the ciliary membrane (depicted in green on the figure) and that a defective BBSome will render these pathways inactive. </ins>In collaboration with the lab of [http://www.hhmi.org/research/investigators/sheffield.html/ Val Sheffield], we have engineered a mouse strain that will allow us to biochemical isolate the BBSome and its associated factors.</div></td></tr>  </table> Fri, 11 Jan 2008 21:24:34 GMT Maxence V. Nachury http://www.openwetware.org/wiki/Talk:Nachury:Research Maxence V. Nachury: /* Discovery of novel ciliary signaling pathways */ http://www.openwetware.org/index.php?title=Nachury:Research&diff=178152&oldid=prev <p><span class="autocomment">Discovery of novel ciliary signaling pathways</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:14, 11 January 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 16:</td> <td colspan="2" class="diff-lineno">Line 16:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Discovery of novel ciliary signaling pathways ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Discovery of novel ciliary signaling pathways ==</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[image:BBS_Organs.jpg|thumb|200px|left]]<del class="diffchange diffchange-inline"><br></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[image:BBS_Organs.jpg|thumb|200px|left]]</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">In collaboration with the lab of </ins>[http://www.hhmi.org/research/investigators/sheffield.html/ Val Sheffield]<ins class="diffchange diffchange-inline">, we have engineered a mouse strain that will allow us to biochemical isolate the BBSome and its associated factors. Given the variety of organ-specific pathologies found in Bardet-Biedl syndrome, it is expected that specific signaling pathways</ins></div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[http://www.hhmi.org/research/investigators/sheffield.html/ Val Sheffield]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>  </table> Fri, 11 Jan 2008 21:14:08 GMT Maxence V. Nachury http://www.openwetware.org/wiki/Talk:Nachury:Research Maxence V. Nachury: /* Vesicular transport to the primary cilium */ http://www.openwetware.org/index.php?title=Nachury:Research&diff=178149&oldid=prev <p><span class="autocomment">Vesicular transport to the primary cilium</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 21:04, 11 January 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 17:</td> <td colspan="2" class="diff-lineno">Line 17:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Discovery of novel ciliary signaling pathways ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Discovery of novel ciliary signaling pathways ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:BBS_Organs.jpg|thumb|200px|left]]<br></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:BBS_Organs.jpg|thumb|200px|left]]<br></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[http://www.hhmi.org/research/investigators/sheffield.html/ Val Sheffield]</ins></div></td></tr>  </table> Fri, 11 Jan 2008 21:04:34 GMT Maxence V. Nachury http://www.openwetware.org/wiki/Talk:Nachury:Research Maxence V. Nachury at 19:37, 11 January 2008 http://www.openwetware.org/index.php?title=Nachury:Research&diff=178110&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 19:37, 11 January 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Template:Nachury}}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Template:Nachury}}</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;"><h1><center>Research</center></h1></del></div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><h1><center>Research</center></h1></ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Vesicular transport to the primary cilium ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Vesicular transport to the primary cilium ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:Cilium_Anderson.jpg|thumb|200px|left]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:Cilium_Anderson.jpg|thumb|200px|left]]</div></td></tr>  </table> Fri, 11 Jan 2008 19:37:47 GMT Maxence V. Nachury http://www.openwetware.org/wiki/Talk:Nachury:Research Maxence V. Nachury at 19:37, 11 January 2008 http://www.openwetware.org/index.php?title=Nachury:Research&diff=178109&oldid=prev <p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">←Older revision</td> <td colspan='2' style="background-color: white; color:black;">Revision as of 19:37, 11 January 2008</td> </tr> <tr><td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Template:Nachury}}</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>{{Template:Nachury}}</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">__TOC__</del></div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;"><h1><center>Research</center></h1></del></div></td><td colspan="2"> </td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><h1><center>Research</center></h1></ins></div></td></tr> <tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">__TOC__</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Vesicular transport to the primary cilium ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Vesicular transport to the primary cilium ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:Cilium_Anderson.jpg|thumb|200px|left]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[image:Cilium_Anderson.jpg|thumb|200px|left]]</div></td></tr>  </table> Fri, 11 Jan 2008 19:37:09 GMT Maxence V. Nachury http://www.openwetware.org/wiki/Talk:Nachury:Research