Newman Lab

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<p class=MsoTitle style='border:none'><span style='font-size:10.0pt;font-family:
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"Times New Roman"'>Curriculum Vitae</span></p>
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 +
<p class=MsoTitle style='border:none'><span style='font-size:10.0pt;font-family:
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"Times New Roman"'>&nbsp;</span></p>
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<p class=MsoNormal><span style='font-size:10.0pt'>Group Webpage: <a
 +
href="http://www.openwetware.org/wiki/Newman_Lab">http://www.openwetware.org/wiki/Newman_Lab</a></span></p>
 +
 
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<p class=MsoTitle style='border:none'><span style='font-size:10.0pt;font-family:
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"Times New Roman"'>&nbsp;</span></p>
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<p class=MsoNormal><b><span style='font-size:10.0pt'>Name</span></b><span
 +
style='font-size:10.0pt'>:     Newman Siu Kwan SZE </span></p>
 +
 
 +
<p class=MsoNormal><b><span style='font-size:10.0pt'>Title</span></b><span
 +
style='font-size:10.0pt'>:      Assistant Professor, School of Biological Sciences, Nanyang Technological University</span></p>
 +
 
 +
<p class=MsoNormal><b><span lang=FR style='font-size:10.0pt'>EMail</span></b><span
 +
lang=FR style='font-size:10.0pt'>:    sksze@ntu.edu.sg</span></p>
 +
 
 +
<p class=MsoNormal><span lang=FR style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><b><u><span lang=FR style='font-size:10.0pt'>EDUCATION</span></u></b><u><span
 +
lang=FR style='font-size:10.0pt'>:</span></u></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>1990-1995               Ph.D.,
 +
University of Hong Kong, Hong Kong</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>1987-1990               B.Sc.,
 +
University of Hong Kong, Hong Kong</span></p>
 +
 
 +
<p class=MsoNormal><u><span style='font-size:10.0pt'><span style='text-decoration:
 +
none'>&nbsp;</span></span></u></p>
 +
 
 +
<p class=MsoNormal><b><u><span style='font-size:10.0pt'>PROFESSIONAL
 +
APPOINTMENTS</span></u></b><u><span style='font-size:10.0pt'>:</span></u></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>2006.6 -                   Assistant
 +
Professor, Nanyang Technological University, Singapore</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>2002.7 – 2006.5      Group
 +
Leader, Genome Institute of Singapore, Singapore</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>2003.7 – 2006.5      Adjunct
 +
Assistant Professor, National University of Singapore, Singapore</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>2005.5 – 2006.5      Adjunct
 +
Assistant Professor, Nanyang Technology University, Singapore</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>2001.5 – 2002.6      Visiting
 +
Scientist, Cornell University, USA</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>1998.6 – 2001.5      Postdoctoral
 +
Fellow, University of Waterloo, Canada</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>1995.5 – 1998.5      Postdoctoral
 +
Fellow, University of Toronto, Canada </span></p>
 +
 
 +
<p class=MsoNormal><u><span style='font-size:10.0pt'><span style='text-decoration:
 +
none'>&nbsp;</span></span></u></p>
 +
 
 +
<p class=MsoNormal style='margin-left:1.0in;text-indent:-1.0in'><b><u><span
 +
style='font-size:10.0pt'>HONORS AND AWARDS</span></u></b><u><span
 +
style='font-size:10.0pt'>:</span></u></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>1.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Human Proteome Organization Annual
 +
Congress - First Prize Poster Award, 2004</span></p>
 +
 
 +
<p class=MsoNormal style='text-indent:.25in'><span style='font-size:10.0pt'>Probing
 +
protein solvent accessible surface by laser induced oxidation and mass
 +
spectrometry</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>2.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>The Croucher Foundation
 +
Fellowships, 1995-97</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>3.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>The Croucher Foundation
 +
Studentships, 1990-93</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>4.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Sir Edward Youde Memorial
 +
Scholarships, 1989-90</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>5.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Du pont Science Scholarships,
 +
1989-90</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>6.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Dow Chemical Scholarships, 1989-90</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>7.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>G.T. Byrne Memorial Prize in
 +
Chemistry, 1989-90</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>8.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Douglas Payne Prizes in Chemistry,
 +
1989-90</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:1.0in;text-indent:-1.0in'><b><u><span
 +
style='font-size:10.0pt'>INVITED SEMINARS:</span></u></b></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.5in;text-indent:-.5in'><span
 +
style='font-size:10.0pt'>1.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Workshop on Proteomics Data
 +
Analysis and Data Mining 2005</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in'><span style='font-size:10.0pt'>Algorithm
 +
for Quantitative Proteome Analysis </span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.5in;text-indent:-.5in'><span
 +
style='font-size:10.0pt'>2.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>5<sup>th</sup> HUGO Pacific
 +
Conference Nov 2004</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.5in;text-indent:-.5in'><span
 +
style='font-size:10.0pt'>        Fourier Transform Mass Spectrometry for Top
 +
Down Proteomics</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.5in;text-indent:-.5in'><span
 +
style='font-size:10.0pt'>3.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>The Mass Spectrometry Society of Japan - The 52nd Annual Conference 2004 </span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>        Application of Top Down Proteomics to
 +
Epigenetics and Gene Regulation</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.5in;text-indent:-.5in'><span
 +
style='font-size:10.0pt'>4.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>The Mass Spectrometry Society of
 +
Japan, Kanto-area Colloquium </span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>        Probing Protein Tertiary Structure and
 +
Interaction by Mass Spectrometry</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.5in;text-indent:-.5in'><span
 +
style='font-size:10.0pt'>5.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Pharmacoproteomics 2003, Tokyo, Japan</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>        Top Down Approach for Proteomics Analysis by
 +
Fourier Transform Mass Spectrometry and Electron Capture Dissociation </span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>6.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>A Workshop on Introduction to
 +
BioMEMS and BioMedical Applications 2003, Institute of Microelectronics, Singapore </span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>        Coupling Capillary Isoelectric Focusing in
 +
Open Microchannel to Mass Spectrometry for Protein Characterization </span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.5in;text-indent:-.5in'><span
 +
style='font-size:10.0pt'>7.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Proteomics in Asia and Oceania
 +
2002, Osaka, Japan </span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>        Fourier Transform Mass Spectrometry and
 +
Electron Capture Dissociation for Protein Characterization</span></p>
 +
 
 +
<p class=MsoNormal style='text-autospace:none'><b><u><span style='font-size:
 +
10.0pt'><span style='text-decoration:none'>&nbsp;</span></span></u></b></p>
 +
 
 +
<p class=MsoNormal style='text-autospace:none'><b><u><span style='font-size:
 +
10.0pt'>SCIENTIFIC SERVICES:</span></u></b></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in;text-autospace:
 +
none'><span style='font-size:10.0pt'>1.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Editorial Board, Journal of Mass
 +
Spectrometry Society of Japan</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in;text-autospace:
 +
none'><span style='font-size:10.0pt'>2.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Proposal Reviewer, Hong Kong Research Grant Council</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in;text-autospace:
 +
none'><span style='font-size:10.0pt'>3.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Proposal Reviewer, BMRC, Singapore</span></p>
 +
 
 +
<p class=MsoNormal style='text-autospace:none'><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p><b><u><span style='font-size:10.0pt'>RESEARCH INTERESTS: </span></u></b></p>
 +
 
 +
<p class=MsoNormal style='text-align:justify'><span style='font-size:10.0pt'>Our
 +
research is devoted to develop and apply advanced proteomic technologies to
 +
decipher human diseases through a rational search for novel disease targets and
 +
medicines. Tandem affinity purification tags have been constructed and utilized
 +
to study proteins that are important to transcriptional and translational
 +
regulatory networks, DNA repair, and apoptotic pathway. To this end, we have
 +
studied Ku70 protein complex and identified several new partners in the nucleus
 +
that function in DNA repair and transcriptional regulation. More importantly,
 +
we have found that Ku70 played a key role in signal transduction and governed
 +
the master switch in apoptotic pathway in the cytoplasm.  Currently, we focus
 +
our efforts to understand the role of Ku70 in cancer development and other
 +
human diseases. Another theme of our research is directed to develop high
 +
sensitive structural based proteomic methodologies to elucidate the molecular
 +
machine operating inside the cell. We have developed a novel laser induced
 +
photochemical protein surface oxidation method to determine protein (or protein
 +
complex) solvent accessible surface. We are applying this technology to map
 +
sites of protein-protein, protein-DNA/RNA, and protein-drug interactions, and
 +
to study their binding kinetics.</span></p>
 +
 
 +
<p><span style='font-size:10.0pt'><img width=576 height=283
 +
[[image:image001.gif]]></span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:9.0pt;font-family:Verdana;color:black'>In
 +
addition, we are developing cutting-edge top-down proteomic technologies based
 +
on LC-MS/MS and LTQ Orbitrap Mass Spectrometry. Protein functions are highly
 +
regulated by their post translational modifications such as phosphorylation,
 +
acetylation and methylation. These modifications are central to cellular
 +
signaling pathways and gene regulatory networks, and therefore important for
 +
cancer therapy and diagnostics. However, it is difficult to study these
 +
modifications using traditional biochemical methods. The top-down proteomic
 +
strategy will enable us to characterize and profile global protein
 +
post-translational modifications. </span></p>
 +
 
 +
<p class=MsoNormal style='text-autospace:none'><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal style='text-autospace:none'><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:1.0in;text-indent:-1.0in'><b><u><span
 +
style='font-size:10.0pt'>SELECTED PUBLICATIONS:</span></u></b></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>1.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Chen L, Sze SK and Yang H, <i>Automated
 +
Intensity Descent Method (AID-HRMS) for Efficient Interpretation of Complex
 +
High Resolution Mass Spectra of Proteins, </i>Analytical Chemistry<i>, </i>2006.
 +
(In Press).<a name="OLE_LINK4"></a></span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>2.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Wong JJY, Pung YF, Sze NSK and
 +
Chin KC, <i>HERC5 is a novel interferon-induced HECT-type E3 protein ligase
 +
that mediates Type I interferon-induced ISGylation of protein targets,</i>
 +
Proceedings of the National Academy of Sciences of the USA, 2006. (Accepted).</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>3.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Wu Q, Chen X, Zhang J, Loh YH, Low
 +
TY, Zhang WW, Zhang WS, Sze SK,  Lim B, and Ng H.H.</span><span
 +
style='font-size:10.0pt'>, <i>Sall4 is a Nanog interacting protein, which
 +
co-occupies Nanog genomic sites in embryonic stem cells</i>, Journal of
 +
Biological Chemistry, 2006. (under review)</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>4.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Guo X, Chan-Park M, Yoon SF, Chun
 +
J, Hua L, and Sze NSK, <i>UV Embossed Polymeric Chip for Protein Separation and
 +
Identification based on Capillary Isoelectric Focusing and MALDI-TOF-MS</i>, Analytical
 +
Chemistry,  <b>78</b>, 3249-3256, 2006.</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>5.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Hua L, Low TY, and Sze NSK, <i>Microwave-assisted
 +
Specific Chemical Digestion for Rapid Protein Identification, </i>Proteomics, <b>6</b>,
 +
586-591, 2006.</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>6.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Aye TT, Low TY, and Sze NSK, <i>Nanosecond
 +
Laser Induced Photochemical Oxidation method for Protein Surface Mapping with
 +
Mass Spectrometry,</i> Analytical Chemistry, <b>77(18), </b>5814-5822, 2005.</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>7.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Mok MLS, Hua Lin, Phua JBC, Wee
 +
MKT, and Sze NSK, <i>Capillary Isoelectric Focusing in Pseudo-closed Channel
 +
Coupled to Matrix Assisted Laser Desorption/Ionization Mass Spectrometry for
 +
Protein Analysis</i>, Analyst, <b>129, </b>109-110, 2004.</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>8.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Sze NSK, Ge Y, Oh H, and McLafferty
 +
FW, <i>Plasma Electron Capture Dissociation for Large Protein</i>, Analytical
 +
Chemistry, <b>75, </b>1599-1603, 2003.</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>9.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Ge Y, ElNaggar M, Sze NSK, Hanbin
 +
Oh, Begley TP, and McLafferty FW, <i>Top Down Proteomic Analysis of Secreted
 +
Proteins from Mycobacterium Tuberculosis by Electron Capture Dissociation Mass
 +
Spectrometry</i>, Journal of the American Society of Mass Spectrometry, <b>14(3),
 +
</b>253-261, 2003. </span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>10.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Ge Y, Lwahor BG, ElNaggar M, Sze
 +
NSK, Begley TP, and McLafferty FW, <i>Protein Oxidation in Viral
 +
Prolyl-4-hydroxylase Characterized by Top Down Tandem Mass Spectrometry</i>,
 +
Protein Science, <b>12, </b>2320-2326, 2003.</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>11.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Oh H, Breuker K, Sze SK, Ge Y,
 +
Carpenter BK, and McLafferty FW,  <i>Secondary and tertiary structures of
 +
gaseous protein ions characterized by electron capture dissociation mass
 +
spectrometry and photofragment spectroscopy.</i>    <a name="OLE_LINK1">Proceedings
 +
Of The </a>National Academy Of Sciences Of The United States Of America, <b>99,
 +
</b>15863-8, 2002.</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>12.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Sze NSK, Ge Y, Oh H, and McLafferty
 +
FW, <i>Top Down Mass Spectrometry of a 29 kDa Protein for Characterization of
 +
Any Posttranslational Modification to Within One Residue</i>, Proceedings of
 +
the National Academy of Sciences of the USA. <b>99, </b>1774-1779, 2002. </span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:1.0in;text-indent:-1.0in'><b><u><span
 +
style='font-size:10.0pt'>PATENTS:</span></u></b></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>1.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Capillary Isoelectic Focusing –
 +
MALDI Device for Protein Analysis</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.25in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>2.<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>Polymer Composite for MALDI Analysis
 +
of Biomolecules. </span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><b><u><span style='font-size:10.0pt'>Lab Members:</span></u></b></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>Ran Dong Yuan</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>Email: rdyuan@ntu.edu.sg</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>Tel: (65) 6316-2852</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>Meng Wei</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>Email: g0402992@nus.edu.sg</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>Tel: (65) 6316-2852</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>NARDEV S/O RAMANATHAN</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>Email: <a
 +
href="mailto:nardev@pmail.ntu.edu.sg">nardev@pmail.ntu.edu.sg</a></span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>Tel: (65) 6316-2852</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><b><u><span style='font-size:10.0pt'>Vacancies:</span></u></b></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>We are looking for
 +
Postdoctoral Fellows, Research Assistants and Graduate Students to join our
 +
multi-disciplinary team in the following area:</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.5in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>1)<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>proteomics technology development:
 +
background in physics, , chemistry, biology or engineering</span></p>
 +
 
 +
<p class=MsoNormal style='margin-left:.5in;text-indent:-.25in'><span
 +
style='font-size:10.0pt'>2)<span style='font:7.0pt "Times New Roman"'>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
</span></span><span style='font-size:10.0pt'>proteomics bioinformatics/mass
 +
spectrometry data analysis: Mathematics, Computer Sciences,  </span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
<p class=MsoNormal><span style='font-size:10.0pt'>&nbsp;</span></p>
 +
 
 +
</div>
 +
 
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</body>
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</html>

Revision as of 21:56, 13 June 2006

NAME: WEN-HSIAO SUN, PH

Curriculum Vitae

 

Group Webpage: http://www.openwetware.org/wiki/Newman_Lab

 

Name:     Newman Siu Kwan SZE

Title:      Assistant Professor, School of Biological Sciences, Nanyang Technological University

EMail:    sksze@ntu.edu.sg

 

EDUCATION:

1990-1995               Ph.D., University of Hong Kong, Hong Kong

1987-1990               B.Sc., University of Hong Kong, Hong Kong

 

PROFESSIONAL APPOINTMENTS:

2006.6 -                   Assistant Professor, Nanyang Technological University, Singapore

2002.7 – 2006.5      Group Leader, Genome Institute of Singapore, Singapore

2003.7 – 2006.5      Adjunct Assistant Professor, National University of Singapore, Singapore

2005.5 – 2006.5      Adjunct Assistant Professor, Nanyang Technology University, Singapore

2001.5 – 2002.6      Visiting Scientist, Cornell University, USA

1998.6 – 2001.5      Postdoctoral Fellow, University of Waterloo, Canada

1995.5 – 1998.5      Postdoctoral Fellow, University of Toronto, Canada

 

HONORS AND AWARDS:

1.        Human Proteome Organization Annual Congress - First Prize Poster Award, 2004

Probing protein solvent accessible surface by laser induced oxidation and mass spectrometry

2.        The Croucher Foundation Fellowships, 1995-97

3.        The Croucher Foundation Studentships, 1990-93

4.        Sir Edward Youde Memorial Scholarships, 1989-90

5.        Du pont Science Scholarships, 1989-90

6.        Dow Chemical Scholarships, 1989-90

7.        G.T. Byrne Memorial Prize in Chemistry, 1989-90

8.        Douglas Payne Prizes in Chemistry, 1989-90

 

INVITED SEMINARS:

1.        Workshop on Proteomics Data Analysis and Data Mining 2005

Algorithm for Quantitative Proteome Analysis

2.        5th HUGO Pacific Conference Nov 2004

        Fourier Transform Mass Spectrometry for Top Down Proteomics

3.        The Mass Spectrometry Society of Japan - The 52nd Annual Conference 2004

        Application of Top Down Proteomics to Epigenetics and Gene Regulation

4.        The Mass Spectrometry Society of Japan, Kanto-area Colloquium

        Probing Protein Tertiary Structure and Interaction by Mass Spectrometry

5.        Pharmacoproteomics 2003, Tokyo, Japan

        Top Down Approach for Proteomics Analysis by Fourier Transform Mass Spectrometry and Electron Capture Dissociation

6.        A Workshop on Introduction to BioMEMS and BioMedical Applications 2003, Institute of Microelectronics, Singapore

        Coupling Capillary Isoelectric Focusing in Open Microchannel to Mass Spectrometry for Protein Characterization

7.        Proteomics in Asia and Oceania 2002, Osaka, Japan

        Fourier Transform Mass Spectrometry and Electron Capture Dissociation for Protein Characterization

 

SCIENTIFIC SERVICES:

1.        Editorial Board, Journal of Mass Spectrometry Society of Japan

2.        Proposal Reviewer, Hong Kong Research Grant Council

3.        Proposal Reviewer, BMRC, Singapore

 

RESEARCH INTERESTS:

Our research is devoted to develop and apply advanced proteomic technologies to decipher human diseases through a rational search for novel disease targets and medicines. Tandem affinity purification tags have been constructed and utilized to study proteins that are important to transcriptional and translational regulatory networks, DNA repair, and apoptotic pathway. To this end, we have studied Ku70 protein complex and identified several new partners in the nucleus that function in DNA repair and transcriptional regulation. More importantly, we have found that Ku70 played a key role in signal transduction and governed the master switch in apoptotic pathway in the cytoplasm.  Currently, we focus our efforts to understand the role of Ku70 in cancer development and other human diseases. Another theme of our research is directed to develop high sensitive structural based proteomic methodologies to elucidate the molecular machine operating inside the cell. We have developed a novel laser induced photochemical protein surface oxidation method to determine protein (or protein complex) solvent accessible surface. We are applying this technology to map sites of protein-protein, protein-DNA/RNA, and protein-drug interactions, and to study their binding kinetics.

In addition, we are developing cutting-edge top-down proteomic technologies based on LC-MS/MS and LTQ Orbitrap Mass Spectrometry. Protein functions are highly regulated by their post translational modifications such as phosphorylation, acetylation and methylation. These modifications are central to cellular signaling pathways and gene regulatory networks, and therefore important for cancer therapy and diagnostics. However, it is difficult to study these modifications using traditional biochemical methods. The top-down proteomic strategy will enable us to characterize and profile global protein post-translational modifications.

 

 

SELECTED PUBLICATIONS:

1.        Chen L, Sze SK and Yang H, Automated Intensity Descent Method (AID-HRMS) for Efficient Interpretation of Complex High Resolution Mass Spectra of Proteins, Analytical Chemistry, 2006. (In Press).

2.        Wong JJY, Pung YF, Sze NSK and Chin KC, HERC5 is a novel interferon-induced HECT-type E3 protein ligase that mediates Type I interferon-induced ISGylation of protein targets, Proceedings of the National Academy of Sciences of the USA, 2006. (Accepted).

3.        Wu Q, Chen X, Zhang J, Loh YH, Low TY, Zhang WW, Zhang WS, Sze SK,  Lim B, and Ng H.H., Sall4 is a Nanog interacting protein, which co-occupies Nanog genomic sites in embryonic stem cells, Journal of Biological Chemistry, 2006. (under review)

4.        Guo X, Chan-Park M, Yoon SF, Chun J, Hua L, and Sze NSK, UV Embossed Polymeric Chip for Protein Separation and Identification based on Capillary Isoelectric Focusing and MALDI-TOF-MS, Analytical Chemistry,  78, 3249-3256, 2006.

5.        Hua L, Low TY, and Sze NSK, Microwave-assisted Specific Chemical Digestion for Rapid Protein Identification, Proteomics, 6, 586-591, 2006.

6.        Aye TT, Low TY, and Sze NSK, Nanosecond Laser Induced Photochemical Oxidation method for Protein Surface Mapping with Mass Spectrometry, Analytical Chemistry, 77(18), 5814-5822, 2005.

7.        Mok MLS, Hua Lin, Phua JBC, Wee MKT, and Sze NSK, Capillary Isoelectric Focusing in Pseudo-closed Channel Coupled to Matrix Assisted Laser Desorption/Ionization Mass Spectrometry for Protein Analysis, Analyst, 129, 109-110, 2004.

8.        Sze NSK, Ge Y, Oh H, and McLafferty FW, Plasma Electron Capture Dissociation for Large Protein, Analytical Chemistry, 75, 1599-1603, 2003.

9.        Ge Y, ElNaggar M, Sze NSK, Hanbin Oh, Begley TP, and McLafferty FW, Top Down Proteomic Analysis of Secreted Proteins from Mycobacterium Tuberculosis by Electron Capture Dissociation Mass Spectrometry, Journal of the American Society of Mass Spectrometry, 14(3), 253-261, 2003.

10.     Ge Y, Lwahor BG, ElNaggar M, Sze NSK, Begley TP, and McLafferty FW, Protein Oxidation in Viral Prolyl-4-hydroxylase Characterized by Top Down Tandem Mass Spectrometry, Protein Science, 12, 2320-2326, 2003.

11.     Oh H, Breuker K, Sze SK, Ge Y, Carpenter BK, and McLafferty FW,  Secondary and tertiary structures of gaseous protein ions characterized by electron capture dissociation mass spectrometry and photofragment spectroscopy.    Proceedings Of The National Academy Of Sciences Of The United States Of America, 99, 15863-8, 2002.

12.     Sze NSK, Ge Y, Oh H, and McLafferty FW, Top Down Mass Spectrometry of a 29 kDa Protein for Characterization of Any Posttranslational Modification to Within One Residue, Proceedings of the National Academy of Sciences of the USA. 99, 1774-1779, 2002.

 

PATENTS:

1.        Capillary Isoelectic Focusing – MALDI Device for Protein Analysis

2.        Polymer Composite for MALDI Analysis of Biomolecules.

 

 

Lab Members:

Ran Dong Yuan

Email: rdyuan@ntu.edu.sg

Tel: (65) 6316-2852

 

 

Meng Wei

Email: g0402992@nus.edu.sg

Tel: (65) 6316-2852

 

 

NARDEV S/O RAMANATHAN

Email: nardev@pmail.ntu.edu.sg

Tel: (65) 6316-2852

 

 

Vacancies:

We are looking for Postdoctoral Fellows, Research Assistants and Graduate Students to join our multi-disciplinary team in the following area:

 

1)       proteomics technology development: background in physics, , chemistry, biology or engineering

2)       proteomics bioinformatics/mass spectrometry data analysis: Mathematics, Computer Sciences,  

 

 

 

 

 

 

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