Nijman

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[[Nijman:Contact | <font face="trebuchet ms" style="color:#ffffff"> '''Contact''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Nijman:Positions | <font face="trebuchet ms" style="color:#ffffff"> '''Positions''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Nijman:Lab Members | <font face="trebuchet ms" style="color:#ffffff"> '''Lab Members''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Nijman:Publications | <font face="trebuchet ms" style="color:#ffffff"> '''Publications''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Nijman:Links | <font face="trebuchet ms" style="color:#ffffff"> '''Links''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Nijman:Other | <font face="trebuchet ms" style="color:#ffffff"> '''Other''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Image:Quote Asimov.png |400px|left]]
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[[Category:Nijman]]
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==About==
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[[Image:Logo CeMM 3.gif|left|250px|Logo CeMM 3.gif]]<br> <br> <br>
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The Nijman lab is at the Center for Molecular Medicine ([http://www.cemm.oeaw.ac.at/ CeMM], pronounce \sam\) in Vienna, Austria . We have recently moved into our new research building right next to [http://en.wikipedia.org/wiki/Vienna_General_Hospital Vienna General Hospital], one of the largest academic hospitals in Europe.
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CeMM is an international, independent and interdisciplinary research institute of the Austrian Academy of Sciences dedicated to research with a human focus.
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“From the clinic to the clinic”
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CeMM’s mission is to combine insight obtained from basic and clinical research and use it to implement the development of innovative therapeutic and diagnostic strategies – from the clinic to the clinic.
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==Research scope==
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[[Image:Cancer vs crab.jpg|200px|right]]
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In the Nijman lab we are particularly interested in cancer and try to understand the cellular circuitry that is misregulated in this disease with the ultimate aim to identify new patient stratified therapeutic strategies.
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Cancer cells differ from their normal counterparts by having acquired numerous genetic and epigenetic changes and have re-arranged their cellular network. As a consequence, cancer cells have become dependent on nodes in these networks that are not critical in normal tissues. We perform experiments to identify these cancer vulnerabilities or <nowiki>"</nowiki>[http://en.wikipedia.org/wiki/Achilles%27_heel Achilles' heels]<nowiki>"</nowiki> of cancer cells using large-scale functional genomics and chemical biology. We are currently focusing on breast and lung cancer.
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<br><br>
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''Figure (right). Breast cancer in a mastectomy specimen (top). The cancerous tumour (pale yellow) resembles the figure of a crab, giving the disease its name.
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==Projects==
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===Synthetic lethal interactions in mammalian cells===
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[[Image:Quote1.png|400px|right]]
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A particular type of cancer vulnerability is called [[synthetic lethality|synthetic lethal/sick]] (SSL), a term derived from classical genetics. SSL occurs when two genetic perturbation are only deleterious to a cell or organism in combination. We have recently established a method to screen large numbers of cancer relevant combinations with the aim to identify novel therapeutic angles for cancer.
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===Cell circuits and cancer: Ubiquitin dynamics===
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Other projects in the lab are generally focussed on cancer-relevant pathways and signaling dynamics, such as [http://en.wikipedia.org/wiki/Ubiquitination ubiquitination]/deubiquitination. To identify deubiquitinating enzymes (DUBs) in pathways or processes of interest we employ [http://en.wikipedia.org/wiki/Rnai RNAi] libraries directed against all DUBs in the human genome. Using this approach we have previously identifid DUBs in [http://en.wikipedia.org/wiki/NF-kB NF-kappaB] signaling, DNA repair and [http://en.wikipedia.org/wiki/Hypoxia_%28medical%29 hypoxia] signaling. Now, we are suing these libraries to identify potential new drug targets for cancer therapy
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[[Image:Ubiquitin cartoon.png|250px|right]] <br>
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''Figure (right). Ribbon representation of ubiquitin protein, highlighting the secondary structure. α-helices are coloured in blue and the β-sheet in green. The typical attachment point for a further ubiquitin molecule in polyubiquitin chain formation, lysine 48, is shown in pink.''
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==Collaborations==
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Collaborations are crucial for modern day science!
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Listed here are some friends and collaborators:
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[http://www.med.nyu.edu/people/huangt03.html Tony Huang] (NYU)
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[http://www.wi.mit.edu/research/fellows/brummelkamp.html Thijn Brummelkamp] (MIT, Whitehead Institute)
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[http://www.nki.nl/Research/Faculty+and+Research/Divisions/Molecular+Carcinogenesis/Bernards.htm Rene Bernards ] (Netherlands Cancer Institute)
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[http://www.broad.mit.edu/about/bios/bio-golub.html Todd Golub] (Broad Institute, MIT/Harvard)
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[http://www.broad.mit.edu/about/bios/bio-root.html Dave Root] (Broad Institute, MIT/Harvard)
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==In the news==
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[http://diepresse.com/home/techscience/wissenschaft/424264/index.do?from=suche.intern.portal Die Presse]
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[http://www.news-medical.net/?id=10026 Medical News]
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Sebastian Nijman wins [[Nijman:Wiener Zukunftspreis |"Future of Vienna award" (Wiener Zukunftspreis)]] See also [http://www.cemm.oeaw.ac.at/?cont=news CeMM News]
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