OHSU Knight CI Genomic Instability Interest Group
Objectives of the OHSU DNA R3 Club
Cross departmental interest group composed of students, postdocs, and faculty.
Time, Location & Logistics
Want to join? All are invited! The meetings are held in MRB 634, typically on the first and last Tuesdays of the month at 9AM. This way, nearly every week will have "DNA Tuesday". For those of you who are new, the second Tuesday is when the Fanconi anemia program project team meets, and the third Tuesday is reserved for the DNA repair videoconference for the DNA Repair Interest Group at NIH. NIH videoconference is held in the CROET 2nd floor conference room (BSAC 2501M).
Details: Begins at 9:00 AM sharp. Speakers please arrive by 8:45 for set up. To allow time for extensive discussion plan to speak for a total of 40 min. Meeting ends officially at 10:00 AM but many participants typically stay longer for lively discussion. Send your slides to Maureen after you present so they can be posted on this site.
Member Labs and Affiliations
Hoatlin Lab Biochemistry and Molecular Biology (BMB)
Thayer Lab BMB
Lu Lab BMB
Lloyd Lab Center for Research on Occupational and Environmental Toxicology (CROET)
Liskay Lab Molecular and Medical Genetics (MMG)
McCullough Lab CROET & MMG
Grompe Lab MMG
Turker Lab CROET
Kurre Lab Pediatrics
Schedule
Coming Soon (please add your guests and seminars of interest to the DNA R3 Club schedule below for planning, or email Maureen [hoatlinm AT ohsu dot edu] with details)
- Dr. Patrick Sung- September 18. Host: Amanda McCullough (CROET)
- Dr. Karlene Cimprich- TBA. Host: Maureen Hoatlin (BMB)
- Dr. Haian Fu from Emory University-TBA. Host: Hua Lu (BMB)
Previous Talks
2006
May 16th: Guest speaker Dr. Junjie Chen from the Mayo Clinic College of Medicine "DNA damage checkpoints and tumorigenesis" Host: Hua Lu (BMB)
May 2: Guest speaker Dr. Rachel Klevit University of Washington, Seattle "Structural and Functional Insights into the BRCA1/BARD1 Ubiquitin Ligase" Host: M. Hoatlin (BMB)
April 24th and 25th: Guest speaker Dr. Mark Kelley Wells Center for Pediatric Research, Indiana University School of Medicine "Going Ape over Ref-1; Translation Implications of the DNA Repair Enzyme Ape1/Ref1 as a DNA Repair and Redox Target" Co-Hosts: M. Hoatlin (BMB) & A. McCullough (MMG)
April 4th: Stephen Lloyd. CROET, "Base excision repair of DNA damaged by reactive oxygen Species"
March 28th: Alex Sobeck (BMB, Hoatlin Lab) will cover highlights of a newly-recognized component of the BLM helicase complex called BLAP75. BLM is a member of the recQ family of 3'-5' DNA helicases, which includes five human homologues (RECQL, BLM, WRN, RECQ4, and RECQ5). Loss-of-function mutations in BLM, WRN, and RECQ4 give rise to Bloom's syndrome (BS), Werner's syndrome (WS), and Rothmund-Thomson syndrome (RTS)....all are cancer susceptibility disorders. Fascinating stuff, and, by the way, Alex co-discovered BLAP75 with Weidong's lab.
March 15th: Extra Meeting. Please join the weekly lab meeting of the Hoatlin Lab (MRB 634 at 1:30-3PM) for the review of the highlights of the Cancer Susceptibility Special Conference by Maureen Hoatlin. Warning: Pictures of DNA repair luminaries in skimpy bathing suits might be displayed.
March 7th: Guest speaker Dr. Stephen Kowalczykowski from the University of California, Davis "Recombinational DNA Repair: Visualization at the Single-Molecule Level" Host: M. Hoatlin (BMB)
February 28th: Stacie Stone (Hoatlin Lab, BMB) will give perspectives and background in preparation for the visit of Stephen Kowalczykowski (UC Davis). Dr. Kowalczykowski’s lab has made major contributions to understanding how certain dual DNA helicases unwind duplex DNA, motoring with great speed along antiparallel tracks.
February 7th: Henri Van de Vrugt (Grompe Lab, MMG) will lead the discussion on assessing new insights and perspectives about the connection between the BACH1 helicase and BRCA1 in the Fanconi Pathway.
February 3rd: Our first speaker this year will be Julie Bailis, PhD from the Salk Institute. The title is "The DNA damage response during replication." This talk will be at a special time, Friday February 3 at 2PM in MRB 634. I have attached 3 review articles suggested by Julie that I hope will prepare you for the type of lively and interactive discussion we have enjoyed in our past meetings. Related papers will be emailed in a timely fashion for the following sessions. Host: M. Hoatlin (BMB)
2005 (The Beginning...)
8/9/05. H. Van de Vrugt (Grompe Lab). Review of FASEB Meeting on Recombination and DNA Repair, Part Duex.
8/2/05. Alex Sobeck (Hoatlin lab). Review of FASEB Meeting on Recombination and DNA Repair.
7/19/05. M. Hoatlin (Hoatlin Lab). DNA Helicases
7/12/05. Dan Pankratz (Thayer Lab). Recombination.
Journal Watch (add your pick and your initials)
- Cell. 2006 Mar 10;124(5):943-55. TopBP1 activates the ATR-ATRIP complex. Kumagai A, Lee J, Yoo HY, Dunphy WG (MEH)
- J Cell Biol. 2006 Jun 5;173(5):673-8. Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress. Woodward AM, Gohler T, Luciani MG, Oehlmann M, Ge X, Gartner A, Jackson DA, Blow JJ. (MEH)
- DNA REPAIR SPECIAL PUBLICATIONS - Chemical Reviews Thematic Issue: DNA Damage and Repair5.1 - Chemical Reviews Thematic Issue: DNA Damageand Repair Guest Editor: James T. Stivers. (MEH)
External Meetings of Interest
For updated list see DNA Repair Interest Group web site. Please let R3 Club know if you are going to any meeting of interest. Also, please consider giving a conference update when you get back. Email Maureen to schedule.
- August 9-13, 2006 Salk DNA Replication and Genome Integrity--Matt Thayer and Dan Pankratz are going
- SEPT 8-12, 2006, BANFF, CANADA ATM WORKSHOP
- Sept 12-16 2006 11th Annual Xenopus Conference Kazusa City, Japan
- SEPTEMBER 16-20, 2006 VANCOUVER, BRITISH COLUMBIA ENVIRONMENTAL MUTAGENESIS SOCIETY
- NOVEMBER 11-16, 2006 GRANADA, SPAIN UNSTABLE MICROSATELLITES & HUMAN DISEASE
- January 17-22 2007 Breckenridge, Colorado Genome Instability and Repair Meeting
Announcements
Organizational meeting coming in late June. We're going to try to do part of the planning electronically via this web site. Agenda (please add points):
- What topics to cover in the next period
- Make sure the day and time is still acceptable to most members
- Section of this website called Journal Watch where members can post articles of interest to the members. The added advantage is that we will develop a set of articles for the membership to work from for teaching and curriculum development.
Please add your comments to the OHSU R3 Club Organizational Discussion Page
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