OSDDMalaria:Arylpyrazole Series

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=== Synthesis ===
=== Synthesis ===
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Core: [http://dx.doi.org/10.1002/jhet.5570240634 Synthesis]
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The core can be synthesised with [http://dx.doi.org/10.1002/jhet.5570240634 apparent ease] from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine.
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[[Image:PMY43-1.png|thumb|center|450px|Synthesis of pyrazole core]]

Revision as of 00:24, 21 March 2012

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Aryl Pyrazole Sub-series

The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK arylpyrrole set.


ChEMBL-NTD TCAMS data set has 89 hits with aryl-pyrazole core; 18 hits with an 5-alkyl aryl pyrazole core; 14 with activity below 500 nanomolar:


Synthesis

The core can be synthesised with apparent ease from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine.

Synthesis of pyrazole core
Synthesis of pyrazole core
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