We are located in the new Cancer Research UK: Cambridge Research Institute. Our research goal is to
understand the systems-level transcriptional mechanisms underlying mammalian cell specification
which are often perturbed in cancer using liver hepatocytes as a model cell-type.
1.1 Transcription and transcriptional regulatory evolution in mammals 1.2 Determinants of tissue-specific transcriptional regulation 1.3 Origin and impact of CTCF binding in mammals 1.4 Evolution of polymerase activity