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{{OSDDMalaria}}
{{OpenSourceMalaria}}


A hub for global efforts in open source drug discovery for malaria. If you are interested in open source drug discovery and would like to do something to combat malaria, then:
[http://opensourcemalaria.org/ Open Source Malaria (OSM)] is aimed at finding new medicines for malaria using open source principles, embodied in the [[Open_Source_Research | 6 Laws of Open Research]]. At the moment the majority of work involves the synthesis of analogs of compounds identified by big pharma, with the aim of improving their potency while making the molecules more "druggable", what is known as a "hit-to-lead" campaign.


* Get an OpenWetWare account
Medicinal chemists should head to the [[OpenSourceMalaria:Story_so_far|project summary]], then the [[OpenSourceMalaria:Compound_Series| individual compound series page]]. The most active series at the moment is [[OpenSourceMalaria:Triazolopyrazine_(TP)_Series|Series 4]].
* Edit this and other pages.
* Contribute to current projects (below) or even start new ones!


== Current Projects ==
This wiki describes where the project is up to, and archives some data and loose ends. For everything else about the project, see the main [http://opensourcemalaria.org/# Project Landing Page]. For a list of current to do items that can be filtered by type and series, see the [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?state=open To Do List].


There are lots of things needed, but the main thing is experimental input. If you're a scientist with access to a lab, open source drug discovery needs you. If you want to know what open source drug discovery is, go [[OSDD:Huh%3F|here]]. For anyone new to the project here is a [[short guide to using the Electronic Lab Notebook]].
==About OSM, What's Needed and how to Contact==


Currently there are three active projects on-going:
The background to the project may be found in the [[OpenSourceMalaria:Story_so_far|Story so Far]]. Publications from the project and other outputs are in the [[OpenSourceMalaria:Links|'''Links''']] page, along with media about the project.


* [[OSDDMalaria:GSK_Arylpyrrole_Series|GSK arylpyrrole series]] - plus a [[OSDDMalaria:GSK Arylpyrrole Series:Story so far|human-readable summary]] of the current project status.
The main resources needed in the OSM project are '''experimental input''', particularly [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=Being+Synthesised+Now&page=1&state=open chemical compound synthesis] and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.
* [[OSDDMalaria:GSK_Triazolourea_Singleton|GSK Triazolourea Singleton]]
* [[OSDDMalaria:GSK_Amino-thienopyrimidine_Series|GSK Amino-thienopyrimidine Series]]


Project entries will be listed at [[OSDDMalaria:Projects|link]] in above menu.
If you have no access to a lab, there are a number of important other things needed, labelled as such on the To Do List, such as things to do with [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=Writing&milestone=&page=1&state=open writing] or [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=PR&milestone=&page=1&state=open PR] to help spread the word.


=== Current Participants ===
Ideally everything happens in the public domain through any of the ways shown on the [http://opensourcemalaria.org/# Landing Page] but you can in the last resort contact the consortium using opensourcemalaria@gmail.com


==== Medicinal Chemistry ====
==Help Maintain this Wiki==


* [[Todd| Todd Group]] at the [http://sydney.edu.au/science/chemistry/ University of Sydney] 
If you would like to improve these wiki pages, you will just need to get an OpenWetWare account ([[OpenWetWare:How_to_join |which is easy]]).
* [http://www.mmv.org/ Medicines for Malaria Venture]
* [http://www.cdriindia.org/sanjay.htm Sanjay Batra] at [http://www.cdriindia.org/home.asp CDRI India]
* [http://malaria.osdd.net/ OSDDm] project at [http://www.osdd.net/about-us/osdd-malaria OSDD CDRI]


==== Biology ====
==Licence==


* [http://www.discoverybiology.org/team/vicky-avery Avery Group] at Discovery Biology, Griffith University
The OSM project's licence unless otherwise stated is [http://creativecommons.org/licenses/by/3.0/ CC-BY-3.0] meaning you can use whatever you want for whatever purpose, provided you cite the project.
* [http://www.bio21.org/group-leaders/bio-chemistry/stuart-ralph Ralph Group], Bio21, Melbourne
* [http://www.openlabfoundation.org/gsk.aspx GSK Tres Cantos], Spain
* [http://www.monash.edu.au/research/profiles/profile.html?sid=2143&pid=3154 Charman Group], Monash University
 
==Open Source Drug Discovery More Generally==
 
A [http://openwetware.org/wiki/OSDDMalaria:OSDD_Malaria_Meeting_Sydney_2012 one-day meeting on open source drug discovery for malaria] was held in February 2012. General issues surrounding the feasibility of open source drug discovery were discussed, followed by more specific malaria-related ideas. These talks are gradually [http://www.youtube.com/playlist?list=PL84A4E62C3C72863D going up on YouTube] with [http://www.thesynapticleap.org/node/390 annotations], and they frame many of the relevant issues, for example the landscape of drug discovery in neglected diseases, and whether patents are necessary in drug discovery. An important message is that open ''source'' drug discovery is where anyone may participate in driving the research, which is different from a more general use of the word "open" where data are made freely available, but perhaps after a delay which essentially prevents participation by others.
 
== Discussion ==
 
This is a wiki, meaning it's meant as a site for how projects are going. For discussion try [http://www.thesynapticleap.org/malaria/community The Synaptic Leap], or the project's [https://plus.google.com/u/0/b/114702323662314783325/114702323662314783325/posts Google+ page], and for updates try the [http://twitter.com/#!/osddmalaria Twitter feed] and [http://www.facebook.com/OSDDforMalaria Facebook Page]. If you would like access to the Twitter or G+ accounts because you've become a member of the project please email OSDD.Malaria@gmail.com.
 
Relevant papers are available in the [http://www.mendeley.com/groups/1846251/osddmalaria/ Mendeley group], to which anyone can add.

Revision as of 16:26, 20 January 2014

Malaria Home        OSM So Far        Compound Series        Links        Open Source Research Home        Tech Ops        FAQ       


Open Source Malaria (OSM) is aimed at finding new medicines for malaria using open source principles, embodied in the 6 Laws of Open Research. At the moment the majority of work involves the synthesis of analogs of compounds identified by big pharma, with the aim of improving their potency while making the molecules more "druggable", what is known as a "hit-to-lead" campaign.

Medicinal chemists should head to the project summary, then the individual compound series page. The most active series at the moment is Series 4.

This wiki describes where the project is up to, and archives some data and loose ends. For everything else about the project, see the main Project Landing Page. For a list of current to do items that can be filtered by type and series, see the To Do List.

About OSM, What's Needed and how to Contact

The background to the project may be found in the Story so Far. Publications from the project and other outputs are in the Links page, along with media about the project.

The main resources needed in the OSM project are experimental input, particularly chemical compound synthesis and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.

If you have no access to a lab, there are a number of important other things needed, labelled as such on the To Do List, such as things to do with writing or PR to help spread the word.

Ideally everything happens in the public domain through any of the ways shown on the Landing Page but you can in the last resort contact the consortium using opensourcemalaria@gmail.com

Help Maintain this Wiki

If you would like to improve these wiki pages, you will just need to get an OpenWetWare account (which is easy).

Licence

The OSM project's licence unless otherwise stated is CC-BY-3.0 meaning you can use whatever you want for whatever purpose, provided you cite the project.

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