Organprotektion Lab

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
(Anesthetic-induced preconditioning and postconditioning)
Line 15: Line 15:
'''Research Fellows:'''
'''Research Fellows:'''
* Dr. Thorsten Smul
* Dr. Thorsten Smul
* Dr. [[Andreas Redel]]
* Dr. Christopher Lotz (currently at UC Los Angeles, USA)
* Dr. Christopher Lotz (currently at UC Los Angeles)
* Dr. [[Jan Stumpner]]
* Dr. [[Jan Stumpner]]
* Dr. Christoph Blomeyer
* Dr. Christoph Blomeyer (currently at Medical College of Wisconsin, Milwaukee, USA)
* Tobias Tischer-Zeitz
* Dr. Sonja Maisch
* Anja Frank
External Collaborator
* Dr. [[Andreas Redel]]
'''MD Students:'''
'''MD Students:'''
Line 34: Line 39:
* Andreas Neuwirth
* Andreas Neuwirth
* Julia Umminger
* Julia Umminger
* Ulrike Kolar

Revision as of 13:58, 19 January 2011

Welcome to our OWW homepage! To get further information, please visit our lab homepage!

Our group in 2007
Our group in 2007


Anesthetic-induced preconditioning and postconditioning

Volatile anesthetics not only induce anesthesia, but also render organs resistant against ischemic damage. For example, the magnitude of an experimentally induced myocardial infarct size can be reduced by more than 50% by the administration of volatile anesthetics, even if the administration has been discontinued prior to the ischemic injury (anesthetic-induced preconditioning, APC). These protective effects are also effective in other organ systems; e.g. the brain. APC is as effective as ischemic preconditioning and thus represent one of the most potent therapeutic strategies of infarct size reduction. Surgery-related temporary ischemia of the heart or the brain can be prevented using APC in the perioperative period.

However, infarct sparing therapies can often only be applied after the patient’s admission to the hospital. Even in this situation the patient can benefit from the application of volatile anesthetics.Recently, it has been described that volatile anesthetics also exert cardioprotective properties when administered after the ischemic injury (anesthetic-induced postconditioning, APOST). This might be of enormous therapeutical implications since myocardial ischemia is often unpredictable.

The intracellular mechanisms underlying APC and APOST are under intense investigation. The projects performed by our group aim to identify triggers, mediators and end-effectors of anesthetic-induced pre- and postconditioning and to characterize their complex intracellular interaction. Particularly, we focuse on ß1- and ß2-adrenergic receptors and their downstream targets. Given the large incidence of perioperative cardiovascular morbidity and mortality and the incidence of myocardial and cerebral infarction, the results of these projects are of high clinical relevance and might provide a better understanding of the cardioprotective properties of volatile anesthetics. They might help to choose the appropriate and protective anaesthesia regime to alleviate cardiovascular mortality and apoplectic insults in the perioperative period.


Head: PD Dr. Markus Lange

Research Fellows:

  • Dr. Thorsten Smul
  • Dr. Christopher Lotz (currently at UC Los Angeles, USA)
  • Dr. Jan Stumpner
  • Dr. Christoph Blomeyer (currently at Medical College of Wisconsin, Milwaukee, USA)
  • Tobias Tischer-Zeitz
  • Dr. Sonja Maisch
  • Anja Frank

External Collaborator

MD Students:

  • Tobias Nefzger
  • Tobias Tischer-Zeitz
  • Johannes Schmidt
  • Verena Schnupp
  • Anja Frank
  • Joanna Pociej
  • Anna Kellermann
  • Nadyia Virstyuk
  • Johannes Richl
  • Teresa Hilz
  • Andreas Beck
  • Andreas Neuwirth
  • Julia Umminger
  • Ulrike Kolar


  • Katerina Pech


  • in vivo model of acute myocardial infarction in two rodent species
  • Western Blot
  • PCR


Error fetching PMID 19934869:
Error fetching PMID 19596824:
Error fetching PMID 19467889:
Error fetching PMID 19303329:
Error fetching PMID 19167913:
Error fetching PMID 19225392:
Error fetching PMID 18580175:
Error fetching PMID 18518784:
Error fetching PMID 18227289:
Error fetching PMID 18156310:
Error fetching PMID 17563879:
Error fetching PMID 17457146:
Error fetching PMID 17242104:
Error fetching PMID 17006071:
Error fetching PMID 16931983:
Error fetching PMID 16766632:
Error fetching PMID 16399333:
Error fetching PMID 16217658:
Error fetching PMID 12457251:
  1. Error fetching PMID 19934869: [Paper1]
  2. Error fetching PMID 19596824: [Paper2]
  3. Error fetching PMID 19467889: [Paper3]
  4. Error fetching PMID 19303329: [Paper4]
  5. Error fetching PMID 19167913: [Paper5]
  6. Error fetching PMID 19225392: [Paper6]
  7. Error fetching PMID 18580175: [Paper7]
  8. Error fetching PMID 18518784: [Paper8]
  9. Error fetching PMID 18227289: [Paper9]
  10. Error fetching PMID 18156310: [Paper10]
  11. Error fetching PMID 17563879: [Paper11]
  12. Error fetching PMID 17457146: [Paper12]
  13. Error fetching PMID 17242104: [Paper13]
  14. Error fetching PMID 17006071: [Paper14]
  15. Error fetching PMID 16931983: [Paper15]
  16. Error fetching PMID 16766632: [Paper16]
  17. Error fetching PMID 16399333: [Paper17]
  18. Error fetching PMID 16217658: [Paper18]
  19. Error fetching PMID 12457251: [Paper19]
All Medline abstracts: PubMed HubMed


Please visit our lab homepage!

Personal tools