Organprotektion Lab

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Our group in 2007
Our group in 2007


Anesthetic-induced preconditioning

Volatile anesthetics not only induce anesthesia, but also render organs resistant against ischemic damage. For example, the magnitude of an experimentally induced myocardial infarct size can be reduced by more than 50% by the administration of volatile anesthetics, even if the administration has been discontinued prior to the ischemic injury (anesthetic-induced preconditioning, APC). These protective effects are also effective in other organ systems; e.g. the brain. APC is as effective as ischemic preconditioning and thus represents one of the most potent therapeutic strategies of infarct size reduction. Surgery-related temporary ischemia of the heart or the brain can be prevented using APC in the perioperative period.

However, infarct sparing therapies can often only be applied after the patient’s admission to the hospital. Even in this situation the patient can benefit from the application of volatile anesthetics: volatile anesthetics reduce myocardial infarct size even when they are administered as late as during reperfusion of the occluded vessel (postconditioning).

The intracellular mechanisms underlying APC are under intense investigation. The projects performed by our group aim to identify triggers, mediators and end-effectors of anesthetic-induced pre- and postconditioning and to characterize their complex intracellular interaction. Given the large incidence of perioperative cardiovascular morbidity and mortality and the incidence of myocardial and cerebral infarction, the results of these projects are of high clinical relevance and might provide a better understanding of the cardioprotective properties of volatile anesthetics. They might help to choose the appropriate and protective anesthesiology regime to alleviate cardiovascular mortality and apoplectic insults in the perioperative period.


Head: Dr. Markus Lange

Research Fellows:

  • Dr. Thorsten Smul
  • Dr. Andreas Redel
  • Dr. Christopher Lotz (currently at UC Los Angeles)
  • Dr. Jan Stumpner
  • Dr. Christoph Blomeyer

Visiting Research Fellow

  • Dr. Feng Gao

MD Students:

  • Tobias Nefzger
  • Tobias Tischer-Zeitz
  • Johannes Schmidt
  • Verena Schnupp
  • Anja Frank
  • Anna Kellermann
  • Nadyia Virstyuk
  • Johannes Richl


  • Katerina Pech


  • in vivo model of acute myocardial infarction in two rodent species
  • Western Blot
  • PCR
  • Elisa


  1. Lange M, Smul TM, Redel A, Lotz C, Jazbutyte V, Schnupp V, Roewer N, and Kehl F. . pmid:18580175. PubMed HubMed [Paper1]
  2. Kranke P, Redel A, Schuster F, Muellenbach R, and Eberhart LH. . pmid:18518784. PubMed HubMed [Paper2]
  3. Redel A, Lange M, Jazbutyte V, Lotz C, Smul TM, Roewer N, and Kehl F. . pmid:18227289. PubMed HubMed [Paper3]
  4. Redel A, Jazbutyte V, Smul TM, Lange M, Eckle T, Eltzschig H, Roewer N, and Kehl F. . pmid:18156310. PubMed HubMed [Paper4]
  5. Muellenbach RM, Kredel M, Said HM, Klosterhalfen B, Zollhoefer B, Wunder C, Redel A, Schmidt M, Roewer N, and Brederlau J. . pmid:17563879. PubMed HubMed [Paper5]
  6. Lange M, Redel A, Roewer N, and Kehl F. . pmid:17457146. PubMed HubMed [Paper6]
  7. Lange M, Smul T, Zimmermann P, Kohlenberger R, Roewer N, and Kehl F. . pmid:17242104. PubMed HubMed [Paper7]
  8. Smul TM, Lange M, Redel A, Burkhard N, Roewer N, and Kehl F. . pmid:17006071. PubMed HubMed [Paper8]
  9. Lange M, Smul TM, Blomeyer CA, Redel A, Klotz KN, Roewer N, and Kehl F. . pmid:16931983. PubMed HubMed [Paper9]
  10. Eckle T, Grenz A, Köhler D, Redel A, Falk M, Rolauffs B, Osswald H, Kehl F, and Eltzschig HK. . pmid:16766632. PubMed HubMed [Paper10]
  11. Lange M, Roewer N, and Kehl F. . pmid:16399333. PubMed HubMed [Paper11]
  12. Golenhofen N, Redel A, Wawrousek EF, and Drenckhahn D. . pmid:16217658. PubMed HubMed [Paper12]
  13. Redel A, Baumgartner W, Golenhofen K, Drenckhahn D, and Golenhofen N. . pmid:12457251. PubMed HubMed [Paper13]
All Medline abstracts: PubMed HubMed


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