March 30, 2006
Minimal genome should be twice the size, study shows
The simplest bacteria need almost twice as many genes to survive than scientists first believed, according to new research published in Nature (30 March 2006).
March 28, 2006
"Accelerated Evolution" Converts RNA Enzyme to DNA Enzyme In Vitro
Scientists at The Scripps Research Institute have successfully converted an RNA enzyme (ribozyme) into a DNA enzyme (deoxyribozyme) through a process of accelerated in vitro evolution. The molecular conversion or transfer of both genetic information and catalytic function between these two different genetic systems, which are both based on nucleic acid-like molecules, is exactly what many scientists believe occurred during the very earliest period of earth's existence.
March 27, 2006
New RNAi tools enable systematic studies of gene function
An international public-private research team led by scientists at the Broad Institute of MIT and Harvard announced today the construction and availability of an extensive library of molecular reagents to silence most human and mouse genes.
Junk DNA may not be so junky after all
Researchers at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins have invented a cost-effective and highly efficient way of analyzing what many have termed "junk" DNA and identified regions critical for controlling gene function. And they have found that these control regions from different species don't have to look alike to work alike.
I created a page where I collect interesting (for me at least) bioinformatics information. The page can be found here.
I am a research scholar working in Prof. Gregory Stephanopoulos' lab. I am mostly interested in complex networks and pattern discovery. You can read more on my background and previous research at my online resume
For now you can visit my blog at: Orhan's Blog for more information. I will update this site with my current research and research resources.
In this section I plan to collect some useful online resources.
My Paper Collection
I am using a site called CiteULike to keep track of all the papers I am reading or planning to read. One can tag papers, create bibliographies automatically and one can also upload the PDFs so that they can be retrieved anytime one desires. You can find my collection of papers (only the user can access the PDFs because of the copyright issues) at Orhan's Paper Collection
Biology News Net is a very useful Biology News collection site.
This site (http://bioinformatics.org/software/index.php3) has a long list of links to Bioinformatics software.
Here I will add the online Gene, Protein, Metabolite databases
Here I will add algorithm sites that might be useful for bioinformatics type of computations.
Research groups that I follow for interesting research.
Here I am planning to add links to some online course materials that I find very useful.
My Research Ideas
My Publications and Presentations
Group Presentation, Literature Review on "Multidimensional Signatures in Antimicrobial Peptides". You can get the pdf for the presentation from here.
Process Design and Control Days
Thesis under Prof. George Stephanopoulos on “Multiscale Modeling, Identification, and Model Predictive Control of Processing Systems.” (May 2000)
“Multi-Scale Modeling, Estimation and Control of Processing Systems”, George Stephanopoulos, Matthew Dyer, and Orhan Karsligil, Computers and Chemical Engineering, 21, p. S797-S803 (1997)
“Multi-Scale Considerations in Linear and Nonlinear Estimation and Control”, George Stephanopoulos, Orhan Karsligil and Matthew Dyer, in Nonlinear Model-Based Control, R. Berber and C. Kravaris (editors), Kluwer (1998)
“Multi-Scale Model-Predictive Control”, Orhan Karsligil, Matthew Dyer and George Stephanopoulos, Proceedings of DYCOPS-5, Kerkyra, Greece (1998)
“Multi-scale Aspects in Model-Predictive Control”, George Stephanopoulos, Orhan Karsligil, and Matthew Dyer, Journal of Process Control, Vol: 10, Issue: 2-3, pp. 275-282 (2000)