Orhan Karsligil

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Dr. Orhan Karsligil Orhan's email
Dr. Orhan Karsligil Orhan's email

Contents

Bioinformatics News

Following are news that I saw on internet on bioinformatics topics. I will try to keep this page up to date. If you find interesting things please let me know by email

April 25, 2006

Scientists design potent anthrax toxin inhibitor

Scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), have engineered a powerful inhibitor of anthrax toxin that worked well in small-scale animal tests. More on this story

April 24, 2006

Anthrax inhibitor counteracts toxin, may lead to new therapeutics

Researchers from Rensselaer Polytechnic Institute and the University of Toronto have designed a nanoscale assembly of molecules that successfully counteracts and inhibits anthrax toxin in animal and laboratory experiments. The novel approach used to neutralize anthrax toxin could be applied in designing potent therapeutics for a variety of pathogens and toxins, according to the researchers. More on this story

April 23, 2006

A new and very potent antimicrobial compound has been discovered

Scientists have discovered a bacteria-fighting compound 100 times more effective than penicillin - in wallaby milk. More on this story

April 22, 2006

Newly discovered protein kills anthrax bacteria by exploding their cell walls

Not all biological weapons are created equal. They are separated into categories A through C, category A biological agents being the scariest: They are easy to spread, kill effectively and call for special actions by the pubic health system. One of these worrisome organisms is anthrax, which has already received its fair share of media attention. But work in Vince Fischetti’s laboratory at Rockefeller University suggests that

A bacterium's final gasp. A bacillus bacterium, a close relative of anthrax, begins to explode after being treated with PlyPH. The PlyPH protein, discovered by Rockefeller scientists, offers several advantages over existing anthrax treatments. a newly discovered protein could be used to fight anthrax infections and even decontaminate areas in which anthrax spores have been released. More on this story

March 30, 2006

Minimal genome should be twice the size, study shows

The simplest bacteria need almost twice as many genes to survive than scientists first believed, according to new research published in Nature (30 March 2006).

More on this story

March 28, 2006

"Accelerated Evolution" Converts RNA Enzyme to DNA Enzyme In Vitro

Scientists at The Scripps Research Institute have successfully converted an RNA enzyme (ribozyme) into a DNA enzyme (deoxyribozyme) through a process of accelerated in vitro evolution. The molecular conversion or transfer of both genetic information and catalytic function between these two different genetic systems, which are both based on nucleic acid-like molecules, is exactly what many scientists believe occurred during the very earliest period of earth's existence.

More on this story

March 27, 2006

New RNAi tools enable systematic studies of gene function

An international public-private research team led by scientists at the Broad Institute of MIT and Harvard announced today the construction and availability of an extensive library of molecular reagents to silence most human and mouse genes.

More on this story

Junk DNA may not be so junky after all

Researchers at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins have invented a cost-effective and highly efficient way of analyzing what many have termed "junk" DNA and identified regions critical for controlling gene function. And they have found that these control regions from different species don't have to look alike to work alike.

More on this story

I created a page where I collect interesting (for me at least) bioinformatics information. The page can be found here.

About Me

I am a research scholar working in Prof. Gregory Stephanopoulos' lab. I am mostly interested in complex networks and pattern discovery. You can read more on my background and previous research at my online resume

For now you can visit my blog at: Orhan's Blog for more information. I will update this site with my current research and research resources.

Resources

In this section I plan to collect some useful online resources.

My Paper Collection

I am using a site called CiteULike to keep track of all the papers I am reading or planning to read. One can tag papers, create bibliographies automatically and one can also upload the PDFs so that they can be retrieved anytime one desires. You can find my collection of papers (only the user can access the PDFs because of the copyright issues) at Orhan's Paper Collection

Biology News

Biology News Net is a very useful Biology News collection site.

Software

This site (http://bioinformatics.org/software/index.php3) has a long list of links to Bioinformatics software.

Online Databases

Here I will add the online Gene, Protein, Metabolite databases

Algorithms

Here I will add algorithm sites that might be useful for bioinformatics type of computations.

Research Groups

Research groups that I follow for interesting research.

Online Courses

Here I am planning to add links to some online course materials that I find very useful.

My Research Ideas

  1. Motif Search
    1. Motifs with gaps
    2. Motif search covering reversed sequences
    3. Multiresolution Motif Search Algorithms
  2. 3D structure and motifs
    1. Not shape but proximity motifs
    2. 3D motifs with gaps
  3. Specialized Clustering Algorithms
  4. Multiscale Analysis of signals
    1. Thresholding
    2. Clustering
    3. Trend analysis
    4. Motif searches


My Publications and Presentations

Current Work

  • Group Presentation, Literature Review on "Multidimensional Signatures in Antimicrobial Peptides". You can get the pdf for the presentation from here.
  • Review of Elementary Mode Analysis. A short summary. You can get the pdf for the summary from here
  • Multiscale Data Smoothing Algorithm (Draft). A multiscale thresholding strategy followed with an optimization step to minimize jumps in the data. You can find the description of the algorithm in the following PDF presentation

Process Design and Control Days

  • “Multi-Scale Modeling, Estimation and Control of Processing Systems”, George Stephanopoulos, Matthew Dyer, and Orhan Karsligil, Computers and Chemical Engineering, 21, p. S797-S803 (1997)
  • “Multi-Scale Considerations in Linear and Nonlinear Estimation and Control”, George Stephanopoulos, Orhan Karsligil and Matthew Dyer, in Nonlinear Model-Based Control, R. Berber and C. Kravaris (editors), Kluwer (1998)
  • “Multi-Scale Model-Predictive Control”, Orhan Karsligil, Matthew Dyer and George Stephanopoulos, Proceedings of DYCOPS-5, Kerkyra, Greece (1998)
  • “Multi-scale Aspects in Model-Predictive Control”, George Stephanopoulos, Orhan Karsligil, and Matthew Dyer, Journal of Process Control, Vol: 10, Issue: 2-3, pp. 275-282 (2000)
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