Pam Kreeger

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'''Pamela K. Kreeger''' (BE postdoctoral)
 
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Ph.D. Northwestern University, Chemical Engineering, 2005
 
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B.S. Valparaiso University, Chemistry, 2000
 
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<font size="4">'''Pamela K. Kreeger'''</font size>
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I am examining how two isoforms of Ras (K-Ras and N-Ras) impact apoptosis in the colon.  Previous studies suggest that activated K-Ras sensitizes cells to apoptosis, while N-Ras provides an anti-apoptotic signal. This work builds upon previous apoptosis models developed in the Lauffenburger lab and attempts to address two important issues.
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== Education==
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<blockquote>2005-2008 Postdoctoral Fellow, Biological Engineering, M.I.T. <br>
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First, can cue-signal-response models be developed where the ‘cue’ is an intrinsic part of the cell, such as a genetic mutation?  To build such a model, we are utilizing a panel of human colon carcinoma cell lines that have distinct genetic manipulations to both K-Ras and N-Ras. These cell lines show different levels of apoptosis following treatment with TNFalpha, and have differences in both basal and stimulated signaling of key intracellular molecules such as ERK and JNK. Secondly, can cue-signal-response models be developed for more complicated paradigms, especially ''in vivo'' models? This project will be done in collaboration with the Jacks lab at MIT, utilizing their genetic mouse models of human cancer. To correlate to our ''in vitro'' studies, we will generate a dataset of intracellular signaling and apoptosis in the intestinal epithelium of mice with defined K-Ras and N-Ras genotypes.
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2000-2005 Ph.D. Chemical Engineering, Northwestern University <br>
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1996-2000 B.S. Chemistry, Valparaiso University <br>
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&bull; [[Lauffenburger:PamKreeger|Previous Research]]
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== Awards ==
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&bull; [[Media:KreegerCV.pdf|Curriculum Vitae]]
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NSF CAREER <br>
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American Cancer Society Postdoctoral Fellow <br>
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Anna Fuller Fund Fellowship in Molecular Oncology <br>
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Northwestern University Fellow <br>
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National Defense Science and Engineering Graduate Fellow <br>
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Cabell Fellow <br>
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[[Media:Kreeger_CV_full_May2012.pdf |Complete CV]] <br>

Revision as of 12:24, 22 May 2012

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Pamela K. Kreeger


Education

2005-2008 Postdoctoral Fellow, Biological Engineering, M.I.T.
2000-2005 Ph.D. Chemical Engineering, Northwestern University
1996-2000 B.S. Chemistry, Valparaiso University

Awards

NSF CAREER
American Cancer Society Postdoctoral Fellow
Anna Fuller Fund Fellowship in Molecular Oncology
Northwestern University Fellow
National Defense Science and Engineering Graduate Fellow
Cabell Fellow


Complete CV
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